Results 41 to 50 of about 29,754 (236)
Nature CommunicationsTherapeutic strategies for peritoneal metastasis in solid tumors are urgently needed. Programming chimeric antigen receptor macrophages (CAR-Ms) in situ offers opportunities for an unmet demand.
Kedan Gu +22 more
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Putative Mechanisms Underlying High Inhibitory Activities of Bimodular DNA Aptamers to Thrombin
Biomolecules, 2019 Nucleic acid aptamers are prospective molecular recognizing elements. Similar to antibodies, aptamers are capable of providing specific recognition due to their spatial structure.
Elena G. Zavyalova +6 more
doaj +1 more source
Sensing and Bio-Sensing Research, 2021 Leukemia is a deadly cancer disease, and according to World Health Organization (WHO) data, there were 437,033 cases across the world in 2018. Early detection of this cancer is very difficult, as its symptoms are hidden and clinically invisible ...
Yuspian Nur +3 more
doaj +1 more source
Aptamers in Immunotherapy [PDF]
Human Gene Therapy, 2008 Numerous nucleic acid ligands, also termed decoys or aptamer, have been developed during the past 20 years that can bind to and inhibit the activity of many proteins. The concept that nucleic acid ligands could modulate the activity of proteins emerged from basic science studies of viruses and early work in the field of gene therapy.
Claudia M, Dollins +2 more
openaire +2 more sources
Advanced Functional Materials, EarlyView.Lipid nanoparticles containing messenger RNA are characterized by sedimentation velocity analytical ultracentrifugation using UltraScan's new Custom Grid algorithm to provide multi‐dimensional distributions for partial specific volume (particle density), molar mass, sedimentation, diffusion, and hydrodynamic radius.
Sophia Bird +8 more
wiley +1 more source
Isolation of Foreign Material-Free Endothelial Progenitor Cells Using CD31 Aptamer and Therapeutic Application for Ischemic Injury. [PDF]
PLoS ONE, 2015 Endothelial progenitor cells (EPCs) can be isolated from human bone marrow or peripheral blood and reportedly contribute to neovascularization. Aptamers are 40-120-mer nucleotides that bind to a specific target molecule, as antibodies do.
Jung Won Yoon +13 more
doaj +1 more source
Novel Complex of PD-L1 Aptamer and Holliday Junction Enhances Antitumor Efficacy in Vivo
Molecules, 2021 Blocking the PD-1/PD-L1 pathway can diminish immunosuppression and enhance anticancer immunity. PD-1/PD-L1 blockade can be realized by aptamers, which have good biocompatibility and can be synthesized in quantity economically.
Ting Li +5 more
doaj +1 more source
Advanced Functional Materials, EarlyView.Nanoscale‐grooved indium gallium oxide (IGO) semiconductors, patterned via thermal nanoimprint lithography (NIL) using CD/DVD templates, are integrated into electrolyte‐gated transistor biosensors to overcome Debye length limitations. Precisely engineered concave–convex nanostructures modulate local electrostatic potentials, extend the effective Debye ...
Jong Yu Song +5 more
wiley +1 more source
Journal of Nucleic Acids, 2017 The binding specificity and affinity of aptamers have long been harnessed as the key elements in the development of aptamer-based assays, particularly aptasensing application.
Mawethu Pascoe Bilibana +4 more
doaj +1 more source
In Situ 3D Bioprinting: Impact of Cross‐Linking on the Adhesive Properties of Hydrogels
Advanced Functional Materials, EarlyView.In situ 3D bioprinting enables the direct deposition of cell‐laden, adhesive biomaterials for on‐site tissue regeneration. This review provides a comprehensive overview of how cross‐linking influences the bioadhesive properties of hydrogels used in 3D bioprinting, highlighting cross‐linking triggers, bioadhesion mechanisms, polymer interpenetration ...
Odile Romero Fernandez +4 more
wiley +1 more source