Results 251 to 260 of about 9,338,478 (297)

Satralizumab treatment in adults with aquaporin-4 immunoglobulin G-seropositive neuromyelitis optica spectrum disorder in clinical practice. [PDF]

open access: yesMult Scler J Exp Transl Clin
Abboud H   +27 more
europepmc   +1 more source

Serum Aquaporin-4 Antibody Status and TGF-β in Neuromyelitis Optica Spectrum Disorder: Impact on Astrocyte Function and Correlation with Disease Activity and Severity. [PDF]

open access: yesNeurol Int
Coutinho-Costa VG   +8 more
europepmc   +1 more source

Aquaporin-4: A Potential Therapeutic Target for Cerebral Edema

open access: yesInternational Journal of Molecular Sciences, 2016
Aquaporin-4 (AQP4) is a family member of water-channel proteins and is dominantly expressed in the foot process of glial cells surrounding capillaries. The predominant expression at the boundaries between cerebral parenchyma and major fluid compartments ...
Guanghui Tang   +2 more
exaly   +2 more sources

Aquaporin‐4 and epilepsy

Glia, 2012
AbstractRecent studies have implicated glial cells in modulation of synaptic transmission, so it is plausible that glial cells may have a functional role in the hyperexcitability characteristic of epilepsy. Indeed, alterations in distinct astrocyte membrane channels, receptors, and transporters have all been associated with the epileptic state.
Devin K, Binder   +2 more
openaire   +2 more sources

The role of aquaporin 4 in the brain

Veterinary Clinical Pathology, 2012
Abstract:Emerging evidence suggests that aquaporin (AQP) 4 water channels play an important role in water homeostasis in the brain. These water channels are most abundant in the cell membrane of astrocytes, but are also present within ependymal cell membranes and in osmosensory areas of the hypothalamus.
Christine, Iacovetta   +2 more
openaire   +2 more sources

Aquaporin-4 and Alzheimer’s Disease

Journal of Alzheimer's Disease, 2016
Alzheimer’s disease (AD) is the most common form of dementia. Although the pathogenesis of AD remains unclear, AD is thought to result from an imbalance in the production and clearance of amyloid-β protein (Aβ). Aquaporin-4 (AQP4) is the major aquaporin in the mammalian brain, is mostly expressed on astrocytic endfeet, and functions as a water ...
Canhong, Yang   +7 more
openaire   +2 more sources

Aquaporin-4 autoantibodies cause asymptomatic aquaporin-4 loss and activate astrocytes in mouse

Journal of Neuroimmunology, 2012
Neuromyelitis optica (NMO) is a central nervous system inflammatory demyelinating disorder. Up to 90% of patients are seropositive for aquaporin-4 autoantibodies (AQP4 Ab). The pathogenetic mechanisms underlying clinical onset and relapse of NMO are uncertain.Study the pathogenicity of AQP4 Ab in the absence of complement activation.Female C57BL/6N ...
Chan, KH   +6 more
openaire   +5 more sources

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