Satralizumab treatment in adults with aquaporin-4 immunoglobulin G-seropositive neuromyelitis optica spectrum disorder in clinical practice. [PDF]
Abboud H +27 more
europepmc +1 more source
The Impact of Aquaporin-4 Deletion on K<sup>+</sup>-Induced Astrocytic Swelling Depends on K<sup>+</sup> Concentration. [PDF]
Bakketun CB +5 more
europepmc +1 more source
Aquaporin-1 and aquaporin-4 in human placental angiogenesis: insights into the critical interaction with caveolin-1. [PDF]
Reppetti J +5 more
europepmc +1 more source
Quantitative analysis of aquaporin-4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG) antibodies titres: correlation with relapses. [PDF]
Nasello M +7 more
europepmc +1 more source
Serum Aquaporin-4 Antibody Status and TGF-β in Neuromyelitis Optica Spectrum Disorder: Impact on Astrocyte Function and Correlation with Disease Activity and Severity. [PDF]
Coutinho-Costa VG +8 more
europepmc +1 more source
Aquaporin-4: A Potential Therapeutic Target for Cerebral Edema
Aquaporin-4 (AQP4) is a family member of water-channel proteins and is dominantly expressed in the foot process of glial cells surrounding capillaries. The predominant expression at the boundaries between cerebral parenchyma and major fluid compartments ...
Guanghui Tang +2 more
exaly +2 more sources
Related searches:
AbstractRecent studies have implicated glial cells in modulation of synaptic transmission, so it is plausible that glial cells may have a functional role in the hyperexcitability characteristic of epilepsy. Indeed, alterations in distinct astrocyte membrane channels, receptors, and transporters have all been associated with the epileptic state.
Devin K, Binder +2 more
openaire +2 more sources
The role of aquaporin 4 in the brain
Veterinary Clinical Pathology, 2012Abstract:Emerging evidence suggests that aquaporin (AQP) 4 water channels play an important role in water homeostasis in the brain. These water channels are most abundant in the cell membrane of astrocytes, but are also present within ependymal cell membranes and in osmosensory areas of the hypothalamus.
Christine, Iacovetta +2 more
openaire +2 more sources
Aquaporin-4 and Alzheimer’s Disease
Journal of Alzheimer's Disease, 2016Alzheimer’s disease (AD) is the most common form of dementia. Although the pathogenesis of AD remains unclear, AD is thought to result from an imbalance in the production and clearance of amyloid-β protein (Aβ). Aquaporin-4 (AQP4) is the major aquaporin in the mammalian brain, is mostly expressed on astrocytic endfeet, and functions as a water ...
Canhong, Yang +7 more
openaire +2 more sources
Aquaporin-4 autoantibodies cause asymptomatic aquaporin-4 loss and activate astrocytes in mouse
Journal of Neuroimmunology, 2012Neuromyelitis optica (NMO) is a central nervous system inflammatory demyelinating disorder. Up to 90% of patients are seropositive for aquaporin-4 autoantibodies (AQP4 Ab). The pathogenetic mechanisms underlying clinical onset and relapse of NMO are uncertain.Study the pathogenicity of AQP4 Ab in the absence of complement activation.Female C57BL/6N ...
Chan, KH +6 more
openaire +5 more sources

