Results 261 to 270 of about 49,483 (288)

Aquaporin 4 deficiency modulates morphine pharmacological actions

Neuroscience Letters, 2008
Acute administration of opioids produces analgesia, while chronic administration induces tolerance and dependence. Aquaporin 4 (AQP4) is most strongly expressed in astrocytes throughout central nervous system, and plays an important role in some pathophysiological processes in brain.
Ning, Wu, Xin-Qiang, Lu, Hai-Tao, Yan, Rui-Bin, Su, Ji-Fang, Wang, Yin, Liu, Gang, Hu, Jin, Li   +7 more
openaire   +2 more sources

Regulation of water permeability through aquaporin-4

Neuroscience, 2010
Aquaporin-4 (AQP4) is a predominant water channel protein in mammalian brains that is distributed with the highest density in the perivascular and subpial astrocyte end-feet. AQP4 is a critical component of an integrated water and potassium homeostasis.
Y, Yukutake, M, Yasui
openaire   +2 more sources

Identification of arylsulfonamides as Aquaporin 4 inhibitors

Bioorganic & Medicinal Chemistry Letters, 2007
Carbonic anhydrase inhibitors AZA, EZA, and 4-acetamidobenzsulfonamide were found to inhibit human AQP4-M23 mediated water transport by 80%, 68%, and 23%, respectively, at 20 microM in an in vitro functional assay. AZA was found to have an IC50 against AQP4 of 0.9 microM. Phloretin was inactive under the same conditions.
Vincent J, Huber, Mika, Tsujita, Maya, Yamazaki, Kenji, Sakimura, Tsutomu, Nakada   +4 more
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Aquaporin‐4 in manganese‐treated cultured astrocytes

Glia, 2010
AbstractManganese in excess is neurotoxic and causes CNS injury resembling that of Parkinson's disease. In brain, astrocytes predominantly take up and accumulate manganese and are thus vulnerable to its toxicity. Manganese was shown to induce cell swelling in cultured astrocytes, and oxidative/nitrosative stress (ONS) mediates such swelling.
Kakulavarapu V Rama, Rao, Arumugam R, Jayakumar, Pichili V B, Reddy, Xiaoying, Tong, Kevin M, Curtis, M D, Norenberg   +5 more
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Anti‐aquaporin‐4 antibody‐positive optic neuritis

Acta Ophthalmologica, 2009
Abstract.Purpose:  It has recently been reported that the anti‐aquaporin‐4 antibody (AQP4‐Ab) can be a specific marker of neuromyelitis optica. We present three cases of optic neuritis (ON) where the patients tested positive for AQP4‐Ab, but showed no neurological signs.Methods:  Sera were obtained from 32 Japanese patients with ON and no other ...
Mineo, Takagi, Keiko, Tanaka, Tone, Suzuki, Atsushi, Miki, Masatoyo, Nishizawa, Haruki, Abe   +5 more
openaire   +2 more sources

Does Aquaporin-4–Seronegative Neuromyelitis Optica Exist?

JAMA Neurology, 2014
With the improvement in anti–aquaporin-4 (AQP4) assay sensitivity to near 90%,1 the concept of seronegative neuromyelitis optica (NMO) is being challenged. The widely accepted criteria forNMOproposed2 in 1999 and revised3 in 2006define NMO as a disease localized to the optic nerves and spinal cord, which is not multiple sclerosis (MS).
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AQP4, Aquaporin 4

2010
Elizabeth Braig, Catherine A. Opere
openaire   +1 more source

Phosphorylation of a wheat aquaporin at two sites enhances both plant growth and defense

Molecular Plant, 2022
Wang Zuodong, Xinhua Ding, Yong-Hua Yang
exaly  

Aquaporin 4 and hydrocephalus

Journal of Neurosurgery: Pediatrics, 2006
James P. McAllister, Janet M. Miller
openaire   +1 more source

Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema

Cell, 2020
Philip Kitchen, Mootaz M Salman, Justin A Macdonald   +2 more
exaly