Aquaporin-4 and Parkinson's Disease. [PDF]
Int J Mol SciThe water-selective channel aquaporin-4 (AQP4) is implicated in water homeostasis and the functioning of the glymphatic system, which eliminates various metabolites from the brain tissue, including amyloidogenic proteins.
Lapshina KV, Ekimova IV.
europepmc +4 more sources
Mechanisms Underlying Aquaporin-4 Subcellular Mislocalization in Epilepsy
Frontiers in Cellular Neuroscience, 2022 Epilepsy is a chronic brain disorder characterized by unprovoked seizures. Mechanisms underlying seizure activity have been intensely investigated.
Jenny I. Szu, Devin K. Binder
doaj +2 more sources
Aquaporin-4 expression in distal myopathy with rimmed vacuoles [PDF]
BMC Neurology, 2012 Background Distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy is clinically characterized by the early involvement of distal leg muscles. The striking pathological features of the myopathy are muscle fibers with rimmed vacuoles.
Hoshi Akihiko +5 more
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Novel Automated Chemiluminescent Immunoassay for the Detection of Autoantibodies Against Aquaporin-4 in Neuromyelitis Optica Spectrum Disorders [PDF]
DiagnosticsBackground/Objectives: Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune-related neurological disease that primarily affects the optic nerve and spinal cord.
Nozomi Yamazaki +3 more
doaj +2 more sources
Aquaporin-4 Expression during Toxic and Autoimmune Demyelination
Cells, 2020 The water channel protein aquaporin-4 (AQP4) is required for a normal rate of water exchange across the blood–brain interface. Following the discovery that AQP4 is a possible autoantigen in neuromyelitis optica, the function of AQP4 in health and disease
Sven Olaf Rohr +6 more
doaj +2 more sources
Aquaporin-4–dependent K+ and water transport modeled in brain extracellular space following neuroexcitation [PDF]
, 2012 Potassium (K(+)) ions released into brain extracellular space (ECS) during neuroexcitation are efficiently taken up by astrocytes. Deletion of astrocyte water channel aquaporin-4 (AQP4) in mice alters neuroexcitation by reducing ECS [K(+)] accumulation ...
Byung‐Ju Jin +3 more
openalex +5 more sources
Osmotic adaptation of nucleus pulposus cells: the role of aquaporin 1, aquaporin 4 and transient receptor potential vanilloid 4 [PDF]
European Cells & Materials, 2021 The microenvironment of the nucleus pulposus is hyperosmotic and fluctuates diurnally due to mechanical loading. Changes in extracellular osmolality result in cell volume alterations, responsiveness to such changes is essential for cellular homeostasis ...
JW Snuggs, RAD Bunning, CL Le Maitre
doaj +1 more source
MYC is a metastasis gene for non-small-cell lung cancer. [PDF]
, 2009 Metastasis is a process by which cancer cells learn to form satellite tumors in distant organs and represents the principle cause of death of patients with solid tumors. NSCLC is the most lethal human cancer due to its high rate of metastasis.
Castro, Inês +8 more
core +18 more sources
Frontiers in Physiology, 2021 Water permeability of the kidney collecting ducts is regulated by the peptide hormone vasopressin. Between minutes and hours (short-term), vasopressin induces trafficking of the water channel protein aquaporin-2 to the apical plasma membrane of the ...
Cheng-Hsuan Ho +4 more
doaj +1 more source
Ravulizumab in Aquaporin‐4–Positive Neuromyelitis Optica Spectrum Disorder
Annals of Neurology, 2023 CHAMPION‐NMOSD (NCT04201262) is a phase 3, open‐label, externally controlled interventional study evaluating the efficacy and safety of the terminal complement inhibitor ravulizumab in adult patients with anti–aquaporin‐4 antibody–positive (AQP4 ...
S. Pittock +14 more
semanticscholar +1 more source