Results 171 to 180 of about 12,794,158 (296)

Repeated heat exposure upregulates skeletal muscle aquaporin-4 expression in male mice. [PDF]

Physiol Rep
Kudo Y, Yazawa N, Shimizu Y, Tomatsuri A, Mizuseki Y, Koshiba-Takeuchi K, Nedachi T.   +6 more
europepmc   +1 more source

Antipsychotics‐Induced Hyposalivation Mediated by Impaired Salivary Ca2+ Signaling

Oral Diseases, EarlyView.
ABSTRACT Objectives Antipsychotic‐induced salivary dysfunction such as hyposalivation is a prevalent clinical challenge that severely compromises oral health and quality of life. Although typical and atypical antipsychotics have their therapeutic target in the central nervous system, their direct molecular mechanisms within the salivary glands remain ...
Chaelin Chung, Soohyun Kim, Yoo‐Bin Kim, Hee‐Kyung Park, Se‐Young Choi   +4 more
wiley   +1 more source

Functional and effective connectivity alterations relate to cognitive performance in aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder. [PDF]

Brain Commun
Leveraro E, Cipriano E, Lombardi G, Currò D, Tazza F, Novi G, Laroni A, Gazzola P, Malentacchi M, Petrucci L, Lapucci C, Inglese M.   +11 more
europepmc   +1 more source

Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders

Oral Diseases, EarlyView.
ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz, Shankara N. Varadarajan, Viktor Drel, Prakash Arullampalam, Mahmoud I. Shoulkamy, Ahmed Al‐Sabi, Brij B. Singh   +6 more
wiley   +1 more source

Evidence for direct and sleep-moderated relationships between aquaporin-4 genetic variants and Alzheimer's disease phenotypes. [PDF]

Alzheimers Dement
Porter T, Armstrong AM, O'Brien EK, Doré V, Bourgeat P, Turner M, Maruff P, Rowe CC, Brown BM, Villemagne VL, Rainey-Smith SR, Laws SM, AIBL Research Group.   +12 more
europepmc   +1 more source

Converging GWAS and Genome Editing Decrypts MsCBF8‐MsGolS2 Regulatory Module for Drought Tolerance Without Yield Penalty in Medicago sativa

Plant Biotechnology Journal, EarlyView.
ABSTRACT Drought constitutes a major abiotic stress limiting alfalfa productivity. To elucidate the genetic basis of drought tolerance, a genome‐wide association study (GWAS) was conducted in alfalfa, which identified a CBF/DREB1 family transcription factor designated MsCBF8.
Yangyang Zhang, Xueqian Jiang, Tian Zhang, Huajuan Leng, Jing Cui, Xu Jiang, Lili Zhang, Zhen Wang, Tiejun Zhang, Qingchuan Yang, Xue Wang, Junmei Kang   +11 more
wiley   +1 more source

Deciphering Role of Endophytes in Plant Defences and Biotic Stress Resilience Across Families

Plant, Cell &Environment, EarlyView.
ABSTRACT Plant families generate distinct repertoires of specialised metabolites that govern their biotic interactions. Endophytes strengthen host plant defence mechanisms and tolerance to biotic challenges by upregulating metabolite biosynthesis, modifying precursor compounds into more potent forms, or by directly synthesising analogous defence ...
S. Aneeqa Noor, Kavita Verma, Nishu, Barkat Hussain, Vartika Mathur   +4 more
wiley   +1 more source

Low Incidence of Relapses After Vaccination in Anti-Aquaporin-4 Antibody-Positive NMOSD. [PDF]

Ann Clin Transl Neurol
Pittock SJ, Nakahara J, Parks B, Allen K, Fam S.   +4 more
europepmc   +1 more source

Molecular Chaperone Networks in Plants: Maintaining Proteostasis and Enhancing Stress Resilience for Crop Improvement

Plant, Cell &Environment, EarlyView.
ABSTRACT Molecular chaperones play a central role in the plant proteostasis machinery by aiding the folding of nascent proteins, preventing aggregation, and repairing or degrading damaged proteins. These functions are especially essential during abiotic and biotic stress, which can destabilise cellular proteins and disrupt metabolic homoeostasis.
Mingfang Yang, Anqin Gao, Tsz‐Yan Chan, Hafiz Mamoon Rehman, Sehar Nawaz, Sehrish Bashir, Noman Mahmood, Muhammad Wajid Ullah, Chunlin Long, Hon‐Ming Lam, Muhammad Arif   +10 more
wiley   +1 more source

Chronic Smoking Impairs Glymphatic Transport and Cognitive Function in Adolescent Mice Through Cardiac, Vascular, and Perivascular Aquaporin-4 Mechanisms. [PDF]

CNS Neurosci Ther
Lv C, Xia C, Li Z, Liu T, Sha Z, Dong S, Qian Y, Liu M, Zhang K, Zhang X, Jiang R, Bie L.   +11 more
europepmc   +1 more source