Results 191 to 200 of about 43,591 (296)

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

Progression Independent of Relapse Activity in Aquaporin-4-IgG-Positive NMOSD: A Decade-Long Cohort Study. [PDF]

Neurol Neuroimmunol Neuroinflamm
Kang YR, Kim KH, Hyun JW, Kim SH, Kim HJ.   +4 more
europepmc   +1 more source

The effects of aquaporin-4 polymorphisms on glymphatic function and motor symptoms in Parkinson's disease. [PDF]

NPJ Parkinsons Dis
Qin J, Fang Y, Duanmu X, Wen J, Wu H, Wu C, Guo T, Zhou C, Zheng Q, Yuan W, Zhu Z, Chen J, Wu J, Jiang M, Zhang B, Xu X, Guan X, Zhang M.   +17 more
europepmc   +1 more source

TMEM16A chloride channels in the female reproductive tract and their role in normal and dysfunctional pregnancy and labour

The Journal of Physiology, EarlyView.
Abstract figure legend TMEM16A plays a pivotal role in setting the duration of the action potential plateau in human uterine smooth muscle. An increase in TMEM16A expression in labour underpins a lengthening of the plateau and this provides time for the contraction to become larger and longer, important for timely successful labour.
Helena C. Parkington, Harold A. Coleman, Penelope M. Sheehan, Shaun P. Brennecke, Marianne Tare   +4 more
wiley   +1 more source

A review of xenobiotic membrane transporter expression within the human placenta: Lessons gained from primary tissue and in vitro methodologies

The Journal of Physiology, EarlyView.
Abstract figure legend A summary of the current knowledge around membrane transporter expression in the most widely used in vitro models of human trophoblasts, including primary placental tissue, cancer cell lines and trophoblast stem cells, as well as the techniques to attempt to mimic the human placenta in vivo.
Rhiannon Pass, Kathryn Wolton, Amanda N. Sferruzzi‐Perri   +2 more
wiley   +1 more source

Frequency of Seroconversion in Aquaporin-4 Antibody Testing: Insights From Real-World Data. [PDF]

Ann Clin Transl Neurol
Ongphichetmetha T, Du M, Vorasoot N, Pittock SJ, Cohen JA, Kunchok A.   +5 more
europepmc   +1 more source

Experimental models of cerebral small vessel disease: Physiological constraints, translational challenges and future directions

The Journal of Physiology, EarlyView.
Abstract figure legend Overview of cerebral small vessel disease (cSVD) pathophysiology and current modelling challenges. Left: clinical burden and key unresolved research questions. Right: neurovascular unit (NVU) architecture highlighting sites of cSVD pathology across arterioles, capillaries and venules, including interactions between endothelial ...
Sophie Beaumont, Tanya Singh, Luana Campos Soares, Mootaz M. Salman   +3 more
wiley   +1 more source

The Role of Aquaporin-4 in Freezing of Gait and Dynamic Balance Learning in Parkinson's Disease. [PDF]

Sci Rep
Jazaeri SZ, Joghataei MT, Jamali A, Montazeri H, Taghizadeh G.   +4 more
europepmc   +1 more source

Vascular smooth muscle cell mechanotransduction: Pathways, phenotypes and emerging technologies

The Journal of Physiology, EarlyView.
Abstract figure legend Vascular smooth muscle cells are exposed to mechanical stimuli from the blood flow and the extracellular matrix. The cells sense the signals from cyclic stretch, shear stress, hydrostatic pressure and matrix stiffness through specialized mechanosensors, such as mechanosensitive ion channels or cell surface receptors including ...
Nivethitha Kota Lakshminaraasimulu, Rachel E. A. Smyth, Aishwarya Prakash, Thomas Iskratsch   +3 more
wiley   +1 more source

Recurrent aquaporin 4-immunoglobulin G-positive neuromyelitis optica spectrum disorder in a patient with long-standing rheumatoid arthritis: A case report. [PDF]

J Int Med Res
Jiang X, Chen J, Wen Y, Yuan L, Zhang J.
europepmc   +1 more source