Results 21 to 30 of about 11,586,786 (268)

Aquaporin-4 autoimmunity [PDF]

Neurology Neuroimmunology & Neuroinflammation, 2015
Neuromyelitis optica (NMO) and a related spectrum of inflammatory CNS disorders are unified by detection of a serum autoantibody specific for the aquaporin-4 (AQP4) water channel, which is abundant in astrocytic foot processes. The classic clinical manifestations of NMO are optic neuritis and longitudinally extensive transverse myelitis.
Vanda A. Lennon, Anastasia Zekeridou
openaire   +3 more sources

Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid β plaque formation in mice

Alzheimer's Research & Therapy, 2022
Background Slowed clearance of amyloid β (Aβ) is believed to underlie the development of Aβ plaques that characterize Alzheimer’s disease (AD). Aβ is cleared in part by the glymphatic system, a brain-wide network of perivascular pathways that supports ...
Matthew J. Simon, M. Wang, O. Ismail, Molly Braun, A. Schindler, Jesica Reemmer, Zhongya Wang, Mariya A Haveliwala, Ryan P. O’Boyle, Warren Han, Natalie E. Roese, M. Grafe, R. Woltjer, D. Boison, Jeffrey J. Iliff   +14 more
semanticscholar   +1 more source

Water Channels Aquaporin 4 and -1 Expression in Subependymoma Depends on the Localization of the Tumors. [PDF]

PLoS ONE, 2015
We analyzed aquaporin 4 and -1 expression in subependymomas, benign and slow growing brain tumors WHO grade I. Ten subependymoma cases were investigated, five of the fossa inferior and five of the fossa superior.Using immunohistochemistry, we observed ...
Susan Noell, Petra Fallier-Becker, Andreas F Mack, Maike Hoffmeister, Rudi Beschorner, Rainer Ritz   +5 more
doaj   +1 more source

Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation

bioRxiv, 2022
The glymphatic system is a fluid transport network of cerebrospinal fluid (CSF) entering the brain along arterial perivascular spaces, exchanging with interstitial fluid (ISF), ultimately establishing directional clearance of interstitial solutes.
R. Gomolka, L. Hablitz, Humberto Mestre, Michael J. Giannetto, Ting Du, Natalie L. Hauglund, Lulu Xie, Weiguo Peng, P. M. Martinez, M. Nedergaard, Yuki Mori   +10 more
semanticscholar   +1 more source

Rituximab abrogates aquaporin-4–specific germinal center activity in patients with neuromyelitis optica spectrum disorders

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance By studying paired blood and deep cervical lymph node samples from patients with neuromyelitis optica spectrum disorders, our data provide evidence for a germinal center–based generation of aquaporin-4 antibodies.
V. Damato, J. Theorell, Adam Al‐Diwani, Anne-Kathrin Kienzler, M. Makuch, Bo Sun, A. Handel, Deniz Akdeniz, A. Berretta, S. Ramanathan, A. Fower, Daniel Whittam, E. Gibbons, N. McGlashan, Edward Green, S. Huda, M. Woodhall, Jacqueline Palace, F. Sheerin, P. Waters, M. Leite, A. Jacob, S. Irani   +22 more
semanticscholar   +1 more source

Aquaporin 4 as a NH3 Channel [PDF]

Journal of Biological Chemistry, 2016
Ammonia is a biologically potent molecule, and the regulation of ammonia levels in the mammalian body is, therefore, strictly controlled. The molecular paths of ammonia permeation across plasma membranes remain ill-defined, but the structural similarity of water and NH3 has pointed to the aquaporins as putative NH3-permeable pores. Accordingly, a range
Assentoft, Mette, Kaptan, Shreyas, Schneider, Hans-Peter, Deitmer, Joachim W, de Groot, Bert L, MacAulay, Nanna   +5 more
openaire   +6 more sources

Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation

Alzheimer's Research & Therapy, 2022
Aquaporin-4 (AQP4) is a channel protein that plays a fundamental role in glymphatic system, a newly described pathway for fluid exchange in the central nervous system, as well as a central figure in a fascinating new theory for the pathophysiology of ...
A. Arighi, M. Arcaro, G. Fumagalli, T. Carandini, A. Pietroboni, L. Sacchi, C. Fenoglio, M. Serpente, F. Sorrentino, G. Isgrò, F. Turkheimer, E. Scarpini, D. Galimberti   +12 more
semanticscholar   +1 more source

Aquaporin-4 and Cerebrovascular Diseases [PDF]

International Journal of Molecular Sciences, 2016
Cerebrovascular diseases are conditions caused by problems with brain vasculature, which have a high morbidity and mortality. Aquaporin-4 (AQP4) is the most abundant water channel in the brain and crucial for the formation and resolution of brain edema.
Xiaobo Yang, Jing Dong, Qiang Dong, Hongyan Ding, Chuyi Huang, Yuping Tang, Heling Chu, Zidan Gao   +7 more
openaire   +3 more sources

Exploring cell membrane water exchange in aquaporin-4-deficient ischemic mouse brain using diffusion-weighted MRI

European Radiology Experimental, 2021
Background Aquaporin-4 is a membrane channel protein that is highly expressed in brain astrocytes and facilitates the transport of water molecules. It has been suggested that suppression of aquaporin-4 function may be an effective treatment for reducing ...
Takuya Urushihata, Hiroyuki Takuwa, Manami Takahashi, Jeff Kershaw, Yasuhiko Tachibana, Nobuhiro Nitta, Sayaka Shibata, Masato Yasui, Makoto Higuchi, Takayuki Obata   +9 more
doaj   +1 more source

Brain aquaporin-4 expression in the rat septic model (immunohistochemical study)

Medičnì Perspektivi, 2022
The study aimed to determine aquaporin-4 expression in different brain regions was performed in Wistar rats subjected to cecal ligation and puncture (CLP) septic model.
T.V.  Shulyatnikova, V.O. Tumanskiy
doaj   +1 more source