Results 11 to 20 of about 16,216 (223)

Causal Pathways Linking Gut Microbiota, Serum Metabolites, and Meningioma Risk: A Mendelian Randomization Analysis. [PDF]

Brain Behav
This Mendelian randomization analysis elucidates causal pathways linking gut microbiota and serum metabolites to meningioma. We identified specific risk factors and found that arachidonic acid potentially mediates the effect of CAG−873 sp001701165 on meningioma risk.
Gong X, Zhang J, He M, Zhang X, Wang K, Yang Y, Zhao Q, Zhao X, Zou W.   +8 more
europepmc   +2 more sources

Induction of Arachidonate 5‐Lipoxygenase and Arachidonate 5‐Lipoxygenase Activating Protein in Macrophages by Multi‐Walled Carbon Nanotubes

The FASEB Journal, 2021
Mammalian lungs respond to inhaled particulates including nanoparticles by eliciting inflammation. The initiation and resolution of inflammation are tightly controlled by potent proinflammatory and pro‐resolving lipid mediators. Dysregulation of lipid mediator production and function contributes to failure of particle clearance and
Chol Seung Lim, Qiang Ma
openaire   +1 more source

Frataxin deficiency increases cyclooxygenase 2 and prostaglandins in cell and animal models of Friedreich's ataxia [PDF]

, 2014
© The Author 2014. Published by Oxford University Press This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution,
Al-Mahdawi, Al-Mahdawi, Block, Campuzano, Campuzano, Capdevila, Capdevila, Castaldo, Chantrel-Groussard, Chen, Cossee, Dewitt, Durr, Durr, Feng, Genki Hayashi, Gino Cortopassi, Harding, John W. Newman, Kang, Koeppen, Li, Liang, Lin, Lu, Mark Pook, Masi, Michael, Miranda, Node, O'Flaherty, Paupe, Piemonte, Piro, Praticò, Qin, Ristow, Rojo, Samuelsson, Sanchez-Mejia, Schulz, Shan, Shi, Shin, Small, Smith, Strokin, Tan, Teismann, Theresa L. Pedersen, Tian, Wardlaw, Wong, Wong, Xi, Yan, Yan Shen, Zhang   +57 more
core   +4 more sources

Genetic Variants in COX2 and ALOX Genes and Breast Cancer Risk in White and Black Women

Frontiers in Oncology, 2021
COX and ALOX genes are involved in inflammatory processes and that may be related to breast cancer risk differentially between White and Black women. We evaluated distributions of genetic variants involved in COX2 and ALOX-related pathways and examined ...
Jennifer M. Mongiovi, Jennifer M. Mongiovi, Chi-Chen Hong, Gary R. Zirpoli, Thaer Khoury, Angela R. Omilian, Bo Qin, Elisa V. Bandera, Song Yao, Christine B. Ambrosone, Zhihong Gong   +10 more
doaj   +1 more source

5‐lipoxygenase‐activating protein is an arachidonate binding protein [PDF]

FEBS Letters, 1993
5‐Lipoxygenase‐activating protein (FLAP) is an 18‐kDa integral membrane protein which is essential for cellular leukotriene (LT) synthesis, and is the target of LT biosynthesis inhibitors. However, the mechanism by which FLAP activates 5‐LO has not been determined.
Mancini, Joseph A., Abramovitz, Mark, Cox, Martha E., Wong, Elizabeth, Charleson, Stella, Perrier, Hélène, Wang, Zhaoyin, Prasit, Peptiboon, Vickers, Philip J.   +8 more
openaire   +2 more sources

Oxidative modification of human lipoproteins by lipoxygenases of different positional specificities

Journal of Lipid Research, 1994
Cellular lipoxygenases have been implicated in foam cell formation during the early stages of atherogenesis. We studied the interaction of lipoxygenases of different positional specificities with human lipoproteins and found that the arachidonate 15 ...
H Kühn, J Belkner, H Suzuki, S Yamamoto
doaj   +1 more source

Withametelin: a biologically active withanolide in cancer, inflammation, pain and depression

Saudi Pharmaceutical Journal, 2020
Withanolides are natural medicinal agents whose safety and therapeutic profiles make them valuable to mankind. Among multiple withanolides, withametelin is underexplored.
Muhammad Waleed Baig, Bakht Nasir, Durdana Waseem, Muhammad Majid, Muhammad Zafar Irshad Khan, Ihsan-ul Haq   +5 more
doaj   +1 more source

Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production. [PDF]

, 2006
Inhibition of neuronal cyclooxygenase-2 (COX-2) and hence prostaglandin E2 (PGE2) synthesis by non-steroidal anti-inflammatory drugs has been suggested to protect neuronal cells in a variety of pathophysiological situations including Alzheimer's disease ...
Akundi, Ravi S., Appel, Kurt, Bhatia, Harsharan S., Candelario-Jalil, Eduardo, Fiebich, Bernd L., Hull, Michael, Lieb, Klaus, Munoz, Eduardo   +7 more
core   +1 more source

5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1. [PDF]

, 2018
The reaction of 5 S,15 S-dihydroperoxyeicosatetraenoic acid (5,15-diHpETE) with human 5-lipoxygenase (LOX), human platelet 12-LOX, and human reticulocyte 15-LOX-1 was investigated to determine the reactivity and relative rates of producing lipoxins (LXs).
Freedman, Cody, Green, Abigail R, Holinstat, Michael, Holman, Theodore R, Liu, Benjamin, Tena, Jennyfer, Tourdot, Benjamin E   +6 more
core   +3 more sources

Genetic variation in the leukotriene pathway is associated with myocardial infarction in the Chinese population

Lipids in Health and Disease, 2019
Background Genetic variation in the genes ALOX5 (arachidonate 5-lipoxygenase), ALOX5AP (arachidonate 5-lipoxygenase-activating protein) and LTA4H (leukotriene A4 hydrolase) has previously been shown to contribute to the risk of MI (myocardial infarction)
Yilan Li, Xueming Xu, Dandan Zhang, Wei Cheng, Yanan Zhang, Bo Yu, Yao Zhang   +6 more
doaj   +1 more source