Results 101 to 110 of about 194,523 (350)

Photoswitchable diacylglycerols enable optical control of protein kinase C. [PDF]

, 2016
Increased levels of the second messenger lipid diacylglycerol (DAG) induce downstream signaling events including the translocation of C1-domain-containing proteins toward the plasma membrane. Here, we introduce three light-sensitive DAGs, termed PhoDAGs,
A Betz, A Burgalossi, A Nadler, A Nadler, A Wuttke, AC Newton, Alexander Gottschalk, C Yang, Carsten Schultz, CI Bargmann, CJ Nolan, D Toullec, DA Jacobson, DA Jacobson, David J Hodson, DB Konrad, Dirk Trauner, Dmytro A Yushchenko, E Oancea, F Plenge-Tellechea, F Varoqueaux, FM Ashcroft, G Reither, GA Rutter, Guy A Rutter, H Fliegl, H Ishihara, J Basu, J Das, JA Frank, JA Lewis, James Allen Frank, Jatin Nagpal, JD Violin, JD Violin, JE Toettcher, Jeong-Seop Rhee, JM Herbert, JS Rhee, JT Fleming, KDB Wierda, L Coussens, M Almena, M Putyrski, MA Ravier, MA Ravier, MS Pessin, N Brose, N Brose, N Brose, Nils Brose, Noa Lipstein, P Bergsten, PA Marignani, PA Wender, PK Dadi, RJ Davis, S Brenner, S Corbalán-García, S Feng, T Hofmann, TR Mahoney, U Kikkawa, X Lou, Y Kurohane Kaneko, Y Zhao   +65 more
core   +3 more sources

Fasting and Refeeding Mediated Phospholipid Remodeling Plays an Important Role in Improving Meat Quality of Aged Laying Hens

Animal Research and One Health, EarlyView.
ABSTRACT This study explored fasting‐induced physiological remodeling effects on meat quality in aged laying hens. Fasting for 15 days (F15) significantly reduced abdominal fat, intermuscular fat width, subcutaneous fat thickness, and liver index versus pre‐fasting (F0) (p < 0.05), which recovered post‐refeeding.
Xiaoran Zhang, Jun Zhang, Yadong Tian, Donghua Li, Yanhua Zhang, Lujie Zhang, Yujie Gong, Xiangtao Kang, Ruirui Jiang   +8 more
wiley   +1 more source

Systematic review of fatty acid composition of human milk from mothers of preterm compared to full-term infants [PDF]

, 2007
Background: Fatty acid composition of human milk serves as guidance for the composition of infant formulae. The aim of the study was to systematically review data on the fatty acid composition of human milk of mothers of preterm compared to full-term ...
Aggett PJ, Berthold Koletzko, Bitman J, Clandinin MT, Clandinin MT, Decsi T, Del Prado M, Demmelmair H, Hamosh M, Innis SM, Jensen CL, Koletzko B, Larque E, Larque E, Larque E, Luukkainen P, Martin JC, Morale SE, Rocquelin G, Rueda R, Szilvia Bokor, Tamás Decsi, Willatts P   +22 more
core   +1 more source

Fresh insights into the light‐induced pineal gland circadian rhythm transmission mechanism derived from mRNA and miRNA profiling

Animal Research and One Health, EarlyView.
Mechanisms of light in regulating the chick pineal clock. Abstract The circadian clock significantly impacts animal health and productivity, with light playing a crucial role in regulating circadian rhythms. However, the mechanisms behind light‐induced circadian transmission remain unclear, particularly in light‐sensitive avian species.
Yunlei Li, Yanyan Sun, Jingwei Yuan, Xiangchen Li, Lei Shi, Adamu Mani Isa, Yuanmei Wang, Pingzhuang Ge, Yunhe Zong, Panlin Wang, Jilan Chen   +10 more
wiley   +1 more source

Adipose-derived stem cells inhibit dermal fibroblast growth and induce apoptosis in keloids through the arachidonic acid-derived cyclooxygenase-2/prostaglandin E2 cascade by paracrine

, 2021
Jinxiu Yang, Shiyi Li, Leren He, Minliang Chen   +3 more
openalex   +1 more source

Deciphering the catalytic and pharmacological mechanisms of Coptis chinensis herbzymes to renovate intestinal microenvironment for colitis alleviation

BMEMat, EarlyView.
The synthesized CCzymes possess both antioxidant enzyme activity and pharmacological properties inherent to Coptis chinensis. By their antioxidant enzyme activity, CCzymes can attenuate oxidative stress within the inflammatory region of ulcerative colitis (UC), while their pharmacological activity acts on macrophage polarization and the intestinal ...
Zhichao Deng, Can Li, Yujie Zhang, Yuanyuan Zhu, Chenxi Xu, Bowen Gao, Mingxin Zhang, Martina H. Stenzel, Kelong Fan, Mingzhen Zhang, Yanyan Jiang   +10 more
wiley   +1 more source

Sonic Hedgehog Activates Phospholipase A2 to Enhance Smoothened Ciliary Translocation

Cell Reports, 2017
The G protein-coupled receptor Smoothened (Smo) is the signal transducer of the Sonic Hedgehog (Shh) pathway. Smo signals through G protein-dependent and -independent routes, with G protein-independent canonical signaling to Gli effectors requiring Smo ...
Angela M. Arensdorf, Miriam E. Dillard, Jacob M. Menke, Matthew W. Frank, Charles O. Rock, Stacey K. Ogden   +5 more
doaj   +1 more source

A multiscale hybrid model for pro-angiogenic calcium signals in a vascular endothelial cell [PDF]

, 2012
Cytosolic calcium machinery is one of the principal signaling mechanisms by which endothelial cells (ECs) respond to external stimuli during several biological processes, including vascular progression in both physiological and pathological conditions ...
A. Balter, A. F. M. Marée, A. F. M. Marée, A. Fiorio Pla, A. Fiorio Pla, A. Fiorio Pla, A. Hunding, A. L. Bauer, A. M. Patton, A. Mottola, A. Tosin, A. W. Mahoney, B. Alberts, B. Nilius, C. C. Fink, C. D. Nobes, C. J. Drake, C. R. Kahl, C. Tomatis, D. Ambrosi, D. E. Clapham, D. Hong, D. Lovisolo, D. Wang, E. C. Kohn, E. C. Kohn, E. D. Perryn, E. L. Watson, F. Bussolino, F. Graner, F. Mac Gabhann, F. Moccia, G. Barbiero, G. Serini, H. Gerhardt, H. Kimura, H.-Y. Kwan, I. Fleming, J. A. Glazier, J. A. Glazier, J. Bennett, J. Howard, J. Klingauf, J. M. Haugh, J. R. Lancaster Jr., J. S. Pollock, J. Sneyd, J. Sneyd, K. S. Bauer, L. A. Blatter, L. Munaron, L. Munaron, L. Munaron, L. Munaron, L. Munaron, L. Munaron, L. Munaron, L. Munaron, L. Santella, L. V. Hryshko, M. A. Albrecht, M. D. Bootman, M. J. Berridge, M. J. Berridge, M. J. Berridge, M. J. Berridge, M. Kraus, M. S. Jafri, M. S. Steinberg, M. S. Steinberg, M. Scianna, M. Scianna, Marco Scianna, N. J. Poplawski, N. J. Savill, N. Metropolis, N. Wang, P. A. Valant, P. Bayley, P. Carmeliet, P. Carmeliet, P. Pacher, R. E. Dolmetsch, R. M. H. Merks, R. M. H. Merks, R. M. H. Merks, R. M. H. Merks, R. Meili, R. Rizzuto, S. Etienne-Manneville, S. Feske, S. Funamoto, S. Huang, S. Lin, S. M. Rafelski, S. Mittara, S. P. Khanapure, S. Wang, T. D. Pollard, T. Walther, W. Coatesworth, Y. Goto, Y. Takai   +102 more
core   +1 more source

Advances in Pharmacological Insights of Borago officinalis: A Comprehensive Review

Biological Diversity, EarlyView.
ABSTRACT Recent growth in phytotherapy and product‐based drug development has increased interest in this plant because of its broad pharmacological activity. This review aims to examine the pharmacological activities, mechanisms, and potential applications of Borago officinalis, focusing on its primary bioactive constituents and therapeutic ...
Zahra Sufwan, Javed Akhtar Ansari, Farogh Ahsan   +2 more
wiley   +1 more source

Platelet and Brain Fatty acid transfer: Hypothesis on Arachidovic Acid and its relationship to Major Depression

Journal of Biological Research, 2009
Depression may be linked to changes of the fatty acid profile in many biological districts such as platelets, plasma phospholipids, rat brain and red blood cells. The platelet is one of the most extensively researched biological markers in psychiatry. In
M. Cocchi, P. Amato, A De Lucia
doaj   +1 more source