Results 41 to 50 of about 3,553 (177)
Targeting the apical domain of the transferrin receptor: Development of a new protein scaffold for cellular delivery. [PDF]
Protein SciAbstract Human transferrin receptor 1 (TfR) is essential for cellular iron homeostasis by internalizing the iron carrier proteins transferrin and ferritin. It is also an entry point for various pathogens, such as South American hemorrhagic fever caused by arenaviruses and the malaria parasite Plasmodium vivax, which utilize TfR to gain access to cells.
Veetil AA +5 more
europepmc +2 more sources
Journal of Medical Virology, Volume 95, Issue 11, November 2023., 2023 Abstract The emerging viruses SARS‐CoV‐2 and arenaviruses cause severe respiratory and hemorrhagic diseases, respectively. The production of infectious particles of both viruses and virus spread in tissues requires cleavage of surface glycoproteins (GPs) by host proprotein convertases (PCs).
Karin Löw +10 more
wiley +1 more source
Re‐emergence of Lassa fever in Nigeria: A new challenge for public health authorities
Health Science Reports, Volume 6, Issue 10, October 2023., 2023 Abstract The Lassa virus is an RNA virus belonging to the Arenaviridae family. It is responsible for Lassa fever, an acute viral zoonosis of the severe hemorrhagic fever type with manifestations of fever, muscle pain, sore throat, nausea, vomiting, and chest and abdominal pain. Lassa fever is endemic in West Africa, where the first case was reported in
Aroma Naeem +5 more
wiley +1 more source
Multiple infections of zoonotic pathogens in wild Brandt's voles (Lasiopodomys brandtii)
Veterinary Medicine and Science, Volume 9, Issue 5, Page 2201-2211, September 2023., 2023 Our research revealed the viral and bacterial diversity in wild Brandt's voles. The characterization and distinctive lineage of some rodent‐specific viruses (Cytomegalovirus, PestVs and Lentiviruses) and rodent‐borne bacteria (Leptospira interrogans and Vibrio cholerae) indicates that wild Brandt's voles may harbor a diversity of viruses and bacteria ...
Yongman Guo +6 more
wiley +1 more source
Lassa fever vaccine candidates: A scoping review of vaccine clinical trials
Tropical Medicine &International Health, Volume 28, Issue 6, Page 420-431, June 2023., 2023 Abstract Objective Lassa fever (LF) is caused by a viral pathogen with pandemic potential. LF vaccines have the potential to prevent significant disease in individuals at risk of infection, but no such vaccine has been licensed or authorised for use thus far.
Giorgia Sulis +2 more
wiley +1 more source
Journal of Applied Toxicology, Volume 43, Issue 5, Page 719-733, May 2023., 2023 Abstract MV‐LASV is an investigational measles Schwarz‐based vaccine for the prevention of Lassa fever. A repeated‐dose toxicity study in cynomolgus macaques was performed to assess the biodistribution and local and systemic toxicological effects. Monkeys received three immunizations of MV‐LASV or saline intramuscularly with a 2‐week interval.
Sabrina Schrauf +6 more
wiley +1 more source
Health Science Reports, Volume 6, Issue 1, January 2023., 2023 Abstract Crimean‐Congo hemorrhagic fever (CCHF) is an infection caused by a tick‐borne virus (genus: Nairovirus, family: Bunyaviridae). The most important vector for CCHF is the ixodid tick. Along with tick bite, direct contact with the virus‐affected animal is responsible for its spread. Pakistan witnessed its first case of CCHF in 1976 and has been a
Shehroze Tabassum +5 more
wiley +1 more source
PLoS Pathogens, 2010 Arenaviridae synthesize viral mRNAs using short capped primers presumably acquired from cellular transcripts by a 'cap-snatching' mechanism. Here, we report the crystal structure and functional characterization of the N-terminal 196 residues (NL1) of the
Benjamin Morin +14 more
doaj +1 more source
A little less aggregation a little more replication: Viral manipulation of stress granules
WIREs RNA, Volume 14, Issue 1, January/February 2023., 2023 Viruses depend entirely on host machinery and therefore aim to conquer the host and defeat its defenses to co‐opt its resources for its own replication. Improved understanding of how viruses counteract host immune responses such as stress granule assembly, detailed here, will inform future antiviral therapeutic strategies.
Matthew J. Brownsword, Nicolas Locker
wiley +1 more source
Ribonucleoprotein transport in Negative Strand RNA viruses
Biology of the Cell, Volume 115, Issue 1, January 2023., 2023 The genome replication of Negative‐sense, single‐stranded RNA viruses most‐often segregate in membrane‐less environments called inclusion bodies (IBs). These “organelles” usually locate far from the cell surface from where new virions are released. Here, for each viral family, we discuss how the genome progeny is transported from the IBs to reach the ...
Cédric Diot +2 more
wiley +1 more source