Results 21 to 30 of about 4,641 (195)

Luminescent reporter cells enable the identification of broad‐spectrum antivirals against emerging viruses

Journal of Medical Virology, Volume 95, Issue 11, November 2023., 2023
Abstract The emerging viruses SARS‐CoV‐2 and arenaviruses cause severe respiratory and hemorrhagic diseases, respectively. The production of infectious particles of both viruses and virus spread in tissues requires cleavage of surface glycoproteins (GPs) by host proprotein convertases (PCs).
Karin Löw, Rebecca Möller, Cora Stegmann, Miriam Becker, Laura Rehburg, Helena Obernolte, Dirk Schaudien, Lisa Oestereich, Armin Braun, Stefan Kunz, Gisa Gerold   +10 more
wiley   +1 more source

Re‐emergence of Lassa fever in Nigeria: A new challenge for public health authorities

Health Science Reports, Volume 6, Issue 10, October 2023., 2023
Abstract The Lassa virus is an RNA virus belonging to the Arenaviridae family. It is responsible for Lassa fever, an acute viral zoonosis of the severe hemorrhagic fever type with manifestations of fever, muscle pain, sore throat, nausea, vomiting, and chest and abdominal pain. Lassa fever is endemic in West Africa, where the first case was reported in
Aroma Naeem, Shafaq Zahid, Muhammad Hassan Hafeez, Arifa Bibi, Shehroze Tabassum, Aymar Akilimali   +5 more
wiley   +1 more source

Differential Disease Susceptibilities in Experimentally Reptarenavirus-Infected Boa Constrictors and Ball Pythons. [PDF]

, 2017
Inclusion body disease (IBD) is an infectious disease originally described in captive snakes. It has traditionally been diagnosed by the presence of large eosinophilic cytoplasmic inclusions and is associated with neurological, gastrointestinal, and ...
Boback, Scott M, DeRisi, Joseph L, Drazenovich, Tracy, Garcia, Valentina E, Hawkins, Michelle G, Hoon-Hanks, Laura L, Keel, M Kevin, Layton, Marylee L, Sanchez-Migallon Guzman, David, Stenglein, Mark D   +9 more
core   +1 more source

Multiple infections of zoonotic pathogens in wild Brandt's voles (Lasiopodomys brandtii)

Veterinary Medicine and Science, Volume 9, Issue 5, Page 2201-2211, September 2023., 2023
Our research revealed the viral and bacterial diversity in wild Brandt's voles. The characterization and distinctive lineage of some rodent‐specific viruses (Cytomegalovirus, PestVs and Lentiviruses) and rodent‐borne bacteria (Leptospira interrogans and Vibrio cholerae) indicates that wild Brandt's voles may harbor a diversity of viruses and bacteria ...
Yongman Guo, Zhengrun Li, Shike Dong, Xiaoyan Si, Na Ta, Hanwei Liang, Lei Xu   +6 more
wiley   +1 more source

Urinary virome perturbations in kidney transplantation [PDF]

, 2018
The human microbiome is important for health and plays a role in essential metabolic functions and protection from certain pathogens. Conversely, dysbiosis of the microbiome is seen in the context of various diseases. Recent studies have highlighted that
Carrie D. Nicora, Kristin Burnum-Johnson, Minnie M. Sarwal, Neil Mercer, Sharvin Nandoe, Sharvin Nandoe, Tara K. Sigdel, Wei-Jun Qian   +7 more
core   +14 more sources

VIPR: a probabilistic algorithm for analysis of microbial detection microarrays [PDF]

, 2010
Background All infectious disease oriented clinical diagnostic assays in use today focus on detecting the presence of a single, well defined target agent or a set of agents.
Adam F Allred, David Wang, Guang Wu, Kael F Fischer, Michael R Holbrook, Robert B Tesh, Tuya Wulan   +6 more
core   +2 more sources

Lassa fever vaccine candidates: A scoping review of vaccine clinical trials

Tropical Medicine &International Health, Volume 28, Issue 6, Page 420-431, June 2023., 2023
Abstract Objective Lassa fever (LF) is caused by a viral pathogen with pandemic potential. LF vaccines have the potential to prevent significant disease in individuals at risk of infection, but no such vaccine has been licensed or authorised for use thus far.
Giorgia Sulis, Alexandra Peebles, Nicole E. Basta   +2 more
wiley   +1 more source

The N-terminal domain of the arenavirus L protein is an RNA endonuclease essential in mRNA transcription.

PLoS Pathogens, 2010
Arenaviridae synthesize viral mRNAs using short capped primers presumably acquired from cellular transcripts by a 'cap-snatching' mechanism. Here, we report the crystal structure and functional characterization of the N-terminal 196 residues (NL1) of the
Benjamin Morin, Bruno Coutard, Michaela Lelke, François Ferron, Romy Kerber, Saïd Jamal, Antoine Frangeul, Cécile Baronti, Rémi Charrel, Xavier de Lamballerie, Clemens Vonrhein, Julien Lescar, Gérard Bricogne, Stephan Günther, Bruno Canard   +14 more
doaj   +1 more source

Protease inhibitors targeting coronavirus and filovirus entry. [PDF]

, 2015
In order to gain entry into cells, diverse viruses, including Ebola virus, SARS-coronavirus and the emerging MERS-coronavirus, depend on activation of their envelope glycoproteins by host cell proteases.
Agudelo, Juliet, Barnard, Dale, Carrion, Ricardo, Lu, Kai, McKerrow, James H, Nunneley, Jerritt W, Pöhlmann, Stefan, Renslo, Adam R, Simmons, Graham, Vedantham, Punitha, Zhou, Yanchen   +10 more
core   +1 more source

Biodistribution and toxicology evaluation of a recombinant measles Schwarz‐based Lassa vaccine in cynomolgus macaques

Journal of Applied Toxicology, Volume 43, Issue 5, Page 719-733, May 2023., 2023
Abstract MV‐LASV is an investigational measles Schwarz‐based vaccine for the prevention of Lassa fever. A repeated‐dose toxicity study in cynomolgus macaques was performed to assess the biodistribution and local and systemic toxicological effects. Monkeys received three immunizations of MV‐LASV or saline intramuscularly with a 2‐week interval.
Sabrina Schrauf, Yvonne Tomberger, Sham Nambulli, W. Paul Duprex, Roland Tschismarov, Erich Tauber, Katrin Ramsauer   +6 more
wiley   +1 more source