Results 21 to 30 of about 2,952 (159)
Journal of Medical Virology, Volume 95, Issue 11, November 2023., 2023 Abstract The emerging viruses SARS‐CoV‐2 and arenaviruses cause severe respiratory and hemorrhagic diseases, respectively. The production of infectious particles of both viruses and virus spread in tissues requires cleavage of surface glycoproteins (GPs) by host proprotein convertases (PCs).
Karin Löw +10 more
wiley +1 more source
Re‐emergence of Lassa fever in Nigeria: A new challenge for public health authorities
Health Science Reports, Volume 6, Issue 10, October 2023., 2023 Abstract The Lassa virus is an RNA virus belonging to the Arenaviridae family. It is responsible for Lassa fever, an acute viral zoonosis of the severe hemorrhagic fever type with manifestations of fever, muscle pain, sore throat, nausea, vomiting, and chest and abdominal pain. Lassa fever is endemic in West Africa, where the first case was reported in
Aroma Naeem +5 more
wiley +1 more source
Multiple infections of zoonotic pathogens in wild Brandt's voles (Lasiopodomys brandtii)
Veterinary Medicine and Science, Volume 9, Issue 5, Page 2201-2211, September 2023., 2023 Our research revealed the viral and bacterial diversity in wild Brandt's voles. The characterization and distinctive lineage of some rodent‐specific viruses (Cytomegalovirus, PestVs and Lentiviruses) and rodent‐borne bacteria (Leptospira interrogans and Vibrio cholerae) indicates that wild Brandt's voles may harbor a diversity of viruses and bacteria ...
Yongman Guo +6 more
wiley +1 more source
Lassa fever vaccine candidates: A scoping review of vaccine clinical trials
Tropical Medicine &International Health, Volume 28, Issue 6, Page 420-431, June 2023., 2023 Abstract Objective Lassa fever (LF) is caused by a viral pathogen with pandemic potential. LF vaccines have the potential to prevent significant disease in individuals at risk of infection, but no such vaccine has been licensed or authorised for use thus far.
Giorgia Sulis +2 more
wiley +1 more source
PLoS Pathogens, 2010 Arenaviridae synthesize viral mRNAs using short capped primers presumably acquired from cellular transcripts by a 'cap-snatching' mechanism. Here, we report the crystal structure and functional characterization of the N-terminal 196 residues (NL1) of the
Benjamin Morin +14 more
doaj +1 more source
Journal of Applied Toxicology, Volume 43, Issue 5, Page 719-733, May 2023., 2023 Abstract MV‐LASV is an investigational measles Schwarz‐based vaccine for the prevention of Lassa fever. A repeated‐dose toxicity study in cynomolgus macaques was performed to assess the biodistribution and local and systemic toxicological effects. Monkeys received three immunizations of MV‐LASV or saline intramuscularly with a 2‐week interval.
Sabrina Schrauf +6 more
wiley +1 more source
A Lassa Fever Live-Attenuated Vaccine Based on Codon Deoptimization of the Viral Glycoprotein Gene
mBio, 2020 Lassa virus (LASV) is endemic in Western Africa and is estimated to infect hundreds of thousands of individuals annually. A considerable number of these infections result in Lassa fever (LF), which is associated with significant morbidity and a case ...
Yingyun Cai +16 more
doaj +1 more source
A Lassa Virus Live-Attenuated Vaccine Candidate Based on Rearrangement of the Intergenic Region
mBio, 2020 Lassa virus (LASV) poses a significant public health problem within the regions of Lassa fever endemicity in Western Africa. LASV infects several hundred thousand individuals yearly, and a considerable number of Lassa fever cases are associated with high
Yingyun Cai +15 more
doaj +1 more source
Emerging Microbes and Infections, 2018 Mammarenavirus RNA was detected in Musser’s bristly mouse (Neacomys musseri) from the Amazon region, and this detection indicated that rodents were infected with a novel mammarenavirus, with the proposed name Xapuri virus (XAPV), which is ...
Jorlan Fernandes +11 more
doaj +1 more source
Vaccine Candidates against Arenavirus Infections
Vaccines, 2023 The viral family Arenaviridae contains several members that cause severe, and often lethal, diseases in humans. Several highly pathogenic arenaviruses are classified as Risk Group 4 agents and must be handled in the highest biological containment ...
Takeshi Saito +5 more
doaj +1 more source