Results 21 to 30 of about 2,974 (161)
PLoS Pathogens, 2010 Arenaviridae synthesize viral mRNAs using short capped primers presumably acquired from cellular transcripts by a 'cap-snatching' mechanism. Here, we report the crystal structure and functional characterization of the N-terminal 196 residues (NL1) of the
Benjamin Morin +14 more
doaj +1 more source
Missed Opportunities for Timely Diagnosis and Effective Therapeutic Management of Prolonged Fever: A Case Study of Confirmed Lassa Fever in N’Zérékoré, Guinea, 2022 [PDF]
Case Reports in Infectious DiseasesBackground Lassa fever is a potentially fatal viral hemorrhagic disease caused by a ribonucleic acid (RNA) virus of the Arenaviridae family, endemic in West Africa. It is highly virulent and contagious in several countries, with a nonspecific clinical presentation that poses a major public health challenge.
Cherif I +13 more
europepmc +2 more sources
Journal of Applied Toxicology, Volume 43, Issue 5, Page 719-733, May 2023., 2023 Abstract MV‐LASV is an investigational measles Schwarz‐based vaccine for the prevention of Lassa fever. A repeated‐dose toxicity study in cynomolgus macaques was performed to assess the biodistribution and local and systemic toxicological effects. Monkeys received three immunizations of MV‐LASV or saline intramuscularly with a 2‐week interval.
Sabrina Schrauf +6 more
wiley +1 more source
A Lassa Fever Live-Attenuated Vaccine Based on Codon Deoptimization of the Viral Glycoprotein Gene
mBio, 2020 Lassa virus (LASV) is endemic in Western Africa and is estimated to infect hundreds of thousands of individuals annually. A considerable number of these infections result in Lassa fever (LF), which is associated with significant morbidity and a case ...
Yingyun Cai +16 more
doaj +1 more source
A Lassa Virus Live-Attenuated Vaccine Candidate Based on Rearrangement of the Intergenic Region
mBio, 2020 Lassa virus (LASV) poses a significant public health problem within the regions of Lassa fever endemicity in Western Africa. LASV infects several hundred thousand individuals yearly, and a considerable number of Lassa fever cases are associated with high
Yingyun Cai +15 more
doaj +1 more source
Emerging Microbes and Infections, 2018 Mammarenavirus RNA was detected in Musser’s bristly mouse (Neacomys musseri) from the Amazon region, and this detection indicated that rodents were infected with a novel mammarenavirus, with the proposed name Xapuri virus (XAPV), which is ...
Jorlan Fernandes +11 more
doaj +1 more source
Vaccine Candidates against Arenavirus Infections
Vaccines, 2023 The viral family Arenaviridae contains several members that cause severe, and often lethal, diseases in humans. Several highly pathogenic arenaviruses are classified as Risk Group 4 agents and must be handled in the highest biological containment ...
Takeshi Saito +5 more
doaj +1 more source
Inhibitors of the Machupo Virus L Endonuclease for Bolivian Hemorrhagic Fever Treatments
MicroorganismsMachupo virus (MACV) is the causal agent of Bolivian Hemorrhagic fever. It is highly pathogenic, has a high mortality rate, and currently lacks specific treatments or vaccines. MACV belongs to the Arenaviridae family, which uses a cap-snatching mechanism
Oluwafoyinsola O. Faniyi +10 more
doaj +1 more source
Revista do Instituto de Medicina Tropical de São Paulo, 1993 Here in is described the clinical and laboratorial findings of a laboratory-acquired infection caused by the virus SP H 114202 (Arenavirus, family Arenaviridae) a recently discovered agent responsible for a viral hemorrhagic fever.
Pedro Fernando da Costa Vasconcelos +5 more
doaj +1 more source
Genetic Evidence for a Tacaribe Serocomplex Virus, Mexico
Emerging Infectious Diseases, 2010 We isolated arenavirus RNA from white-toothed woodrats (Neotoma leucodon) captured in a region of Mexico in which woodrats are food for humans. Analyses of nucleotide and amino acid sequence data indicated that the woodrats were infected with a novel ...
Catherine C. Inizan +5 more
doaj +1 more source