Inhibition of Arenaviridae nucleoprotein exonuclease by bisphosphonate
IUCrJ, 2022 Arenaviruses are emerging enveloped negative-sense RNA viruses that cause neurological and hemorrhagic diseases in humans. Currently, no FDA-approved vaccine or therapeutic agent is available except for ribavirin, which must be administered early during ...
Thi Hong Van Nguyen +5 more
doaj +5 more sources
Brothers in Arms: Structure, Assembly and Function of Arenaviridae Nucleoprotein [PDF]
Viruses, 2020 Arenaviridae is a family of viruses harbouring important emerging pathogens belonging to the Bunyavirales order. Like in other segmented negative strand RNA viruses, the nucleoprotein (NP) is a major actor of the viral life cycle being both (i) the ...
Nicolas Papageorgiou +8 more
doaj +5 more sources
Local Maintenance and Genomic Diversity of Lymphocytic Choriomeningitis Virus in Natural Populations of House Mice in the Czech Republic Over a 24-Year Period. [PDF]
Zoonoses Public HealthABSTRACT Lymphocytic choriomeningitis virus (LCMV) is a neglected rodent‐borne zoonotic virus primarily infecting house mice. The virus can be highly pathogenic, particularly in immunocompromised individuals and in congenital infections. LCMV is distributed worldwide but shows local clustering, probably due to the highly structured populations of its ...
Jezkova I +5 more
europepmc +2 more sources
ICTV Virus Taxonomy Profile: Arenaviridae 2023. [PDF]
J Gen Virol, 2023 Arenaviridae is a family for ambisense RNA viruses with genomes of about 10.5 kb that infect mammals, snakes, and fish. The arenavirid genome consists of two or three single-stranded RNA segments and encodes a nucleoprotein (NP), a glycoprotein (GP) and a large (L) protein containing RNA-directed RNA polymerase (RdRP) domains; some ...
Radoshitzky SR +12 more
europepmc +7 more sources
Direct observation of membrane insertion by enveloped virus matrix proteins by phosphate displacement [PDF]
, 2013 Enveloped virus release is driven by poorly understood proteins that are functional analogs of the coat protein assemblies that mediate intracellular vesicle trafficking.
Al-Mulla, Hawaa M. N +7 more
core +9 more sources
The unusual finding of peripheral lymphadenopathy among confirmed Lassa fever patients in Nigeria
Future Science OA, 2023 Lassa fever is a viral haemorrhagic fever belonging to the arenaviridae family that is well known to be endemic to West Africa. The clinical presentation of the disease ranges from asymptomatic to fulminant illness.
Sampson O Owhin +12 more
doaj +1 more source
Observation of arenavirus nucleoprotein heptamer assembly
FEBS Open Bio, 2021 Arenaviruses are enveloped viruses containing a segmented, negative, and ambisense single‐stranded RNA genome wrapped with a nucleoprotein (NP). The NP is the most abundant viral protein in infected cells and plays a critical role in both replication ...
Nicolas Papageorgiou +6 more
doaj +1 more source
A metagenomic insight into the Yangtze finless porpoise virome
Frontiers in Veterinary Science, 2022 The Yangtze finless porpoise (Neophocaena phocaenoides asiaeorientalis) inhabiting the Yantze River, China is critically endangered because of the influences of infectious disease, human activity, and water contamination.
Zhigang Liu +18 more
doaj +1 more source
The role of platelets in the pathogenesis of viral hemorrhagic fevers. [PDF]
PLoS Neglected Tropical Diseases, 2014 Viral hemorrhagic fevers (VHF) are acute zoonotic diseases that, early on, seem to cause platelet destruction or dysfunction. Here we present the four major ways viruses affect platelet development and function and new evidence of molecular factors that ...
Juan C Zapata +2 more
doaj +1 more source
Widespread recombination, reassortment, and transmission of unbalanced compound viral genotypes in natural arenavirus infections. [PDF]
, 2015 Arenaviruses are one of the largest families of human hemorrhagic fever viruses and are known to infect both mammals and snakes. Arenaviruses package a large (L) and small (S) genome segment in their virions.
Chang, Li-Wen +13 more
core +6 more sources