Results 11 to 20 of about 2,974 (161)

Brothers in Arms: Structure, Assembly and Function of Arenaviridae Nucleoprotein [PDF]

Viruses, 2020
Arenaviridae is a family of viruses harbouring important emerging pathogens belonging to the Bunyavirales order. Like in other segmented negative strand RNA viruses, the nucleoprotein (NP) is a major actor of the viral life cycle being both (i) the ...
Nicolas Papageorgiou, Maria Spiliopoulou, Thi-Hong Van Nguyen, Afroditi Vaitsopoulou, Elsie Yekwa Laban, Karine Alvarez, Irene Margiolaki, Bruno Canard, François Ferron   +8 more
doaj   +5 more sources

Local Maintenance and Genomic Diversity of Lymphocytic Choriomeningitis Virus in Natural Populations of House Mice in the Czech Republic Over a 24-Year Period. [PDF]

Zoonoses Public Health
ABSTRACT Lymphocytic choriomeningitis virus (LCMV) is a neglected rodent‐borne zoonotic virus primarily infecting house mice. The virus can be highly pathogenic, particularly in immunocompromised individuals and in congenital infections. LCMV is distributed worldwide but shows local clustering, probably due to the highly structured populations of its ...
Jezkova I, Fornůsková A, Ďureje Ľ, Macholán M, Piálek J, de Bellocq JG.   +5 more
europepmc   +2 more sources

The unusual finding of peripheral lymphadenopathy among confirmed Lassa fever patients in Nigeria

Future Science OA, 2023
Lassa fever is a viral haemorrhagic fever belonging to the arenaviridae family that is well known to be endemic to West Africa. The clinical presentation of the disease ranges from asymptomatic to fulminant illness.
Sampson O Owhin, Chukuyem Abejegah, Lanre O Olatunde, Nelson A Adedosu, Olufemi O Ayodeji, Timothy R Folorunso, Joachim Azegbeobor, Peter E Akhideno, George O Akpede, Joseph A Ayeyemi, Oyebanji Z Olowosusi, Cyril Erameh, Liasu A Ahmed   +12 more
doaj   +1 more source

Observation of arenavirus nucleoprotein heptamer assembly

FEBS Open Bio, 2021
Arenaviruses are enveloped viruses containing a segmented, negative, and ambisense single‐stranded RNA genome wrapped with a nucleoprotein (NP). The NP is the most abundant viral protein in infected cells and plays a critical role in both replication ...
Nicolas Papageorgiou, Afroditi Vaitsopoulou, Awa Diop, Thi Hong Van Nguyen, Bruno Canard, Karine Alvarez, François Ferron   +6 more
doaj   +1 more source

A metagenomic insight into the Yangtze finless porpoise virome

Frontiers in Veterinary Science, 2022
The Yangtze finless porpoise (Neophocaena phocaenoides asiaeorientalis) inhabiting the Yantze River, China is critically endangered because of the influences of infectious disease, human activity, and water contamination.
Zhigang Liu, Zhigang Liu, Xin Ding, Muhammad Shahan Haider, Farah Ali, Han Yu, Xin Chen, Shuaishuai Tan, Yuan Zu, Wenlong Liu, Bangzhi Ding, Aifang Zheng, Jinsong Zheng, Zhengyi Qian, Hassan Ashfaq, Daoping Yu, Daoping Yu, Kun Li, Kun Li   +18 more
doaj   +1 more source

The role of platelets in the pathogenesis of viral hemorrhagic fevers. [PDF]

PLoS Neglected Tropical Diseases, 2014
Viral hemorrhagic fevers (VHF) are acute zoonotic diseases that, early on, seem to cause platelet destruction or dysfunction. Here we present the four major ways viruses affect platelet development and function and new evidence of molecular factors that ...
Juan C Zapata, Dermot Cox, Maria S Salvato   +2 more
doaj   +1 more source

Luminescent reporter cells enable the identification of broad‐spectrum antivirals against emerging viruses

Journal of Medical Virology, Volume 95, Issue 11, November 2023., 2023
Abstract The emerging viruses SARS‐CoV‐2 and arenaviruses cause severe respiratory and hemorrhagic diseases, respectively. The production of infectious particles of both viruses and virus spread in tissues requires cleavage of surface glycoproteins (GPs) by host proprotein convertases (PCs).
Karin Löw, Rebecca Möller, Cora Stegmann, Miriam Becker, Laura Rehburg, Helena Obernolte, Dirk Schaudien, Lisa Oestereich, Armin Braun, Stefan Kunz, Gisa Gerold   +10 more
wiley   +1 more source

Re‐emergence of Lassa fever in Nigeria: A new challenge for public health authorities

Health Science Reports, Volume 6, Issue 10, October 2023., 2023
Abstract The Lassa virus is an RNA virus belonging to the Arenaviridae family. It is responsible for Lassa fever, an acute viral zoonosis of the severe hemorrhagic fever type with manifestations of fever, muscle pain, sore throat, nausea, vomiting, and chest and abdominal pain. Lassa fever is endemic in West Africa, where the first case was reported in
Aroma Naeem, Shafaq Zahid, Muhammad Hassan Hafeez, Arifa Bibi, Shehroze Tabassum, Aymar Akilimali   +5 more
wiley   +1 more source

Multiple infections of zoonotic pathogens in wild Brandt's voles (Lasiopodomys brandtii)

Veterinary Medicine and Science, Volume 9, Issue 5, Page 2201-2211, September 2023., 2023
Our research revealed the viral and bacterial diversity in wild Brandt's voles. The characterization and distinctive lineage of some rodent‐specific viruses (Cytomegalovirus, PestVs and Lentiviruses) and rodent‐borne bacteria (Leptospira interrogans and Vibrio cholerae) indicates that wild Brandt's voles may harbor a diversity of viruses and bacteria ...
Yongman Guo, Zhengrun Li, Shike Dong, Xiaoyan Si, Na Ta, Hanwei Liang, Lei Xu   +6 more
wiley   +1 more source

Lassa fever vaccine candidates: A scoping review of vaccine clinical trials

Tropical Medicine &International Health, Volume 28, Issue 6, Page 420-431, June 2023., 2023
Abstract Objective Lassa fever (LF) is caused by a viral pathogen with pandemic potential. LF vaccines have the potential to prevent significant disease in individuals at risk of infection, but no such vaccine has been licensed or authorised for use thus far.
Giorgia Sulis, Alexandra Peebles, Nicole E. Basta   +2 more
wiley   +1 more source