Results 51 to 60 of about 3,553 (177)
Strategic Preparedness of Broad-Spectrum Antivirals for Rapid Response Towards Next Pandemics. [PDF]
Small SciNanoengineered broad‐spectrum antivirals (BSAs) represent a transformative approach to pandemic preparedness. Unlike virus‐specific drugs requiring separate development, BSAs act across multiple viral families through nanoengineering strategies that enhance solubility, bioavailability, and host‐targeted activity.
N SR, Jin GW, Choy JH.
europepmc +2 more sources
A Lassa Fever Live-Attenuated Vaccine Based on Codon Deoptimization of the Viral Glycoprotein Gene
mBio, 2020 Lassa virus (LASV) is endemic in Western Africa and is estimated to infect hundreds of thousands of individuals annually. A considerable number of these infections result in Lassa fever (LF), which is associated with significant morbidity and a case ...
Yingyun Cai +16 more
doaj +1 more source
Vaccine Candidates against Arenavirus Infections
Vaccines, 2023 The viral family Arenaviridae contains several members that cause severe, and often lethal, diseases in humans. Several highly pathogenic arenaviruses are classified as Risk Group 4 agents and must be handled in the highest biological containment ...
Takeshi Saito +5 more
doaj +1 more source
A Lassa Virus Live-Attenuated Vaccine Candidate Based on Rearrangement of the Intergenic Region
mBio, 2020 Lassa virus (LASV) poses a significant public health problem within the regions of Lassa fever endemicity in Western Africa. LASV infects several hundred thousand individuals yearly, and a considerable number of Lassa fever cases are associated with high
Yingyun Cai +15 more
doaj +1 more source
Genetic detection and characterization of Lujo virus, a new hemorrhagic fever-associated arenavirus from southern Africa. [PDF]
PLoS Pathogens, 2009 Lujo virus (LUJV), a new member of the family Arenaviridae and the first hemorrhagic fever-associated arenavirus from the Old World discovered in three decades, was isolated in South Africa during an outbreak of human disease characterized by nosocomial ...
Thomas Briese +11 more
doaj +1 more source
Genetic Evidence for a Tacaribe Serocomplex Virus, Mexico
Emerging Infectious Diseases, 2010 We isolated arenavirus RNA from white-toothed woodrats (Neotoma leucodon) captured in a region of Mexico in which woodrats are food for humans. Analyses of nucleotide and amino acid sequence data indicated that the woodrats were infected with a novel ...
Catherine C. Inizan +5 more
doaj +1 more source
Outbreak of lassa fever in Nigeria: measures for prevention and control
The Pan African Medical Journal, 2016 Lassa fever, an acute viral haemorrhagic fever, extremely virulent and often infectious, occurs very frequently in different parts of Nigeria [1-4] and affects approximately 100,000-500,000 persons per year in West Africa.
Kehinde Charles Mofolorunsho
doaj +1 more source
Imported Lassa Fever, Pennsylvania, USA, 2010
Emerging Infectious Diseases, 2010 We report a case of Lassa fever in a US traveler who visited rural Liberia, became ill while in country, sought medical care upon return to the United States, and subsequently had his illness laboratory confirmed.
Valerianna Amorosa +13 more
doaj +1 more source
Selection and Characterization of Single-Domain Antibodies for Detection of Lassa Nucleoprotein
Antibodies, 2020 Lassa virus is the etiologic agent of Lassa fever, an acute and often fatal illness endemic to West Africa. It is important to develop new reagents applicable either for the specific diagnosis or as improved therapeutics for the treatment of Lassa fever.
George P. Anderson +3 more
doaj +1 more source