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Generation of Reporter-Expressing New World Arenaviruses: A Systematic Comparison

Viruses, 2022
Replication-competent reporter-expressing viruses are crucial tools in molecular virology with applications that range from antiviral screening to live-cell imaging of protein spatiotemporal dynamics.
Lucie Fénéant, Anne Leske, Karla Günther, Allison Groseth   +3 more
doaj   +4 more sources

Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses [PDF]

Nature Communications, 2018
The five known New World hemorrhagic fever arenaviruses use the same entry receptor, but their viral glycoproteins are markedly different. Here, the authors isolate monoclonal antibodies from a Junin virus vaccinated person that cross-neutralize Machupo ...
Lars E. Clark, Selma Mahmutovic, Donald D. Raymond, Taleen Dilanyan, Takaaki Koma, John T. Manning, Sundaresh Shankar, Silvana C. Levis, Ana M. Briggiler, Delia A. Enria, Kai W. Wucherpfennig, Slobodan Paessler, Jonathan Abraham   +12 more
doaj   +6 more sources

Animal Models of Pathogenic New World Arenaviruses

Microorganisms
Since the emergence of Junín virus in 1953, pathogenic New World arenaviruses have remained a public health concern. These viruses, which also include Machupo virus, Guanarito virus, Sabiá virus, and Chapare virus, cause acute viral hemorrhagic fever and
Alexander V. Alvarado, Robert W. Cross, Thomas W. Geisbert, Courtney Woolsey   +3 more
doaj   +3 more sources

Antibodies to the Glycoprotein GP2 Subunit Cross-React between Old and New World Arenaviruses

mSphere, 2018
Arenaviruses pose a major public health threat and cause numerous infections in humans each year. Although most viruses belonging to this family do not cause disease in humans, some arenaviruses, such as Lassa virus and Machupo virus, are the etiological
Fatima Amanat, James Duehr, Lisa Oestereich, Kathryn M. Hastie, Erica Ollmann Saphire, Florian Krammer   +5 more
doaj   +4 more sources

Structure and stabilization of the antigenic glycoprotein building blocks of the New World mammarenavirus spike complex [PDF]

mBio
The spillover of New World (NW) arenaviruses from rodent reservoirs into human populations poses a continued risk to human health. NW arenaviruses present a glycoprotein (GP) complex on the envelope surface of the virion, which orchestrates host cell ...
Guido C. Paesen, Weng M. Ng, Simon Kimuda, Geoff Sutton, Katie J. Doores, Thomas A. Bowden   +5 more
doaj   +4 more sources

Temporal changes in pathology and viral RNA distribution in guinea pigs following separate infection with two New World Arenaviruses.

PLoS Neglected Tropical Diseases, 2023
Numerous arenaviruses have been identified throughout the Americas and a subset of these viruses cause viral hemorrhagic fever in humans. This study compared the pathology and viral RNA distribution in Hartley guinea pigs challenged with two human ...
Curtis Cline, Xiankun Zeng, Todd M Bell, Carl Shaia, Paul Facemire, Janice Williams, Neil Davis, April Babka, Edwin Picado, Colin Fitzpatrick, Joseph W Golden   +10 more
doaj   +4 more sources

Contrasting Modes of New World Arenavirus Neutralization by Immunization-Elicited Monoclonal Antibodies

mBio, 2022
Transmission of the New World hemorrhagic fever arenaviruses Junín virus (JUNV) and Machupo virus (MACV) to humans is facilitated, in part, by the interaction between the arenavirus GP1 glycoprotein and the human transferrin receptor 1 (hTfR1).
Weng M. Ng, Mehmet Sahin, Stefanie A. Krumm, Jeffrey Seow, Antra Zeltina, Karl Harlos, Guido C. Paesen, Daniel D. Pinschewer, Katie J. Doores, Thomas A. Bowden   +9 more
doaj   +2 more sources

Molecular organization of the New World arenavirus spike glycoprotein complex. [PDF]

Nat Microbiol
Of the multiple arenaviruses that cause haemorrhagic fevers in the Americas, all lack reliable therapeutic options, and only one has a vaccine. The arenavirus glycoprotein complex (GPC) binds cellular receptors and mediates pH-dependent fusion of viral ...
Mann CJ, Yang P, Olal D, Fan X, Smith KN, Clark LE, Krammer F, Bian Y, Abraham J.   +8 more
europepmc   +2 more sources

A hTfR1 Receptor-Specific VHH Antibody Neutralizes Pseudoviruses Expressing Glycoproteins from Junín and Machupo Viruses [PDF]

Viruses
The Junín virus (JUNV) is one of the New World arenaviruses that cause severe hemorrhagic fever. Human transferrin receptor 1 (hTfR1) has been identified as the main receptor for JUNV for virus entry into host cells.
Qinglin Kang, Gege Li, Yan Wu, Shaoyan Wang, Zhengshan Chen, Xiaodong Zai, Xiaoyan Pan, Rong Wang, Jiansheng Lu, Peng Du, Zhixin Yang, Xiangyang Chi, Gengfu Xiao, Junjie Xu   +13 more
doaj   +2 more sources

Genomic characterization of Sabiá virus in Brazil, 2019-2020: Implications for diagnostics, virus evolution, and receptor binding. [PDF]

PLoS Neglected Tropical Diseases
Between December 2019 and January 2020, two patients suspected of having severe yellow fever were admitted to a tertiary healthcare facility in São Paulo, Brazil, presenting with acute hemorrhagic syndrome and neurological alterations; both cases had ...
Ingra M Claro, Erika R Manuli, Camila A M da Silva, Thaís M Coletti, Philippe Lemey, Ana Catharina Nastri, Luciana Vilas Boas Casadio, Amaro Nunes Duarte-Neto, Joshua Quick, Camila M Romano, Charles Whittaker, Sarah C Hill, Carlos A Prete, Darlan S Candido, Filipe R R Moreira, Mariana S Ramundo, Ian Nunes Valença, Jaqueline G de Jesus, Flavia C S Sales, Mariana S Cunha, Juliana M Guerra, Maria Cassia Mendes-Correa, Tania R Tozetto-Mendoza, Marcilio Jorge Fumagalli, Yeh-Li Ho, Peter Simmonds, Weng M Ng, Thomas A Bowden, William M de Souza, Oliver G Pybus, Anna S Levin, Nicholas Loman, Ester C Sabino, Nuno R Faria   +33 more
doaj   +2 more sources