PLoS Pathogens, 2009 The ability of a New World (NW) clade B arenavirus to enter cells using human transferrin receptor 1 (TfR1) strictly correlates with its ability to cause hemorrhagic fever.
Jonathan Abraham +8 more
doaj +6 more sources
Differential Immune Responses to New World and Old World Mammalian Arenaviruses [PDF]
International Journal of Molecular Sciences, 2017 Some New World (NW) and Old World (OW) mammalian arenaviruses are emerging, zoonotic viruses that can cause lethal hemorrhagic fever (HF) infections in humans.
H. Ly
semanticscholar +3 more sources
Journal of Virology, 2020 Arenavirus NPs contain a highly conserved DEDDh ExoN motif, through which LASV NP degrades virus-derived, immunostimulatory dsRNA in biochemical assays to eliminate the danger signal and inhibit the innate immune response.
E. Mateer +4 more
semanticscholar +4 more sources
Comparison of the Innate Immune Responses to Pathogenic and Nonpathogenic Clade B New World Arenaviruses [PDF]
Journal of Virology, 2019 New World (NW) arenaviruses are a diverse family of emerging zoonotic viruses that merit significant attention as important public health problems. The close genetic relationship of nonpathogenic NW arenaviruses with their highly pathogenic cousins ...
Hector Moreno +4 more
semanticscholar +3 more sources
Guinea Pig Transferrin Receptor 1 Mediates Cellular Entry of Junín Virus and Other Pathogenic New World Arenaviruses [PDF]
Journal of Virology, 2019 JUNV is one of five known NWAs that cause viral hemorrhagic fever in humans. Countermeasures against JUNV infection are limited to immunization with the Candid#1 vaccine and immune plasma, which are available only in Argentina.
Brady T. Hickerson +4 more
semanticscholar +5 more sources
The phylogeny of New World (Tacaribe complex) arenaviruses.
Virology, 1996 Several New World (Tacaribe complex) arenaviruses (Arenaviridae) are known to cause severe hemorrhagic disease in humans. Phylogenetic reconstruction of the Tacaribe complex arenaviruses previously has been limited by the relative scarcity of sequence ...
M. D. Bowen, C. J. Peters, S. Nichol
semanticscholar +3 more sources
Structural basis for receptor recognition by New World hemorrhagic fever arenaviruses [PDF]
Nature Structural & Molecular Biology, 2010 New World hemorrhagic fever arenaviruses are rodent-borne agents that cause severe human disease. The GP1 subunit of the surface glycoprotein mediates cell attachment through transferrin receptor 1 (TfR1).
J. Abraham +4 more
semanticscholar +3 more sources
Receptor determinants of zoonotic transmission of New World hemorrhagic fever arenaviruses [PDF]
Proceedings of the National Academy of Sciences, 2008 Transferrin receptor 1 (TfR1) is a cellular receptor for the New World hemorrhagic fever arenaviruses Machupo (MACV), Junín (JUNV), and Guanarito (GTOV). Each of these viruses is specifically adapted to a distinct rodent host species, but all cause human
S. Radoshitzky +11 more
semanticscholar +3 more sources
Transferrin receptor 1 in the zoonosis and pathogenesis of New World hemorrhagic fever arenaviruses
Current Opinion in Microbiology, 2011 Highlights ► Transferrin receptor 1 (TfR1) is the cellular receptor for New World hemorrhagic fever arenaviruses. ► Commonalities between human TfR1 and TfR1 of arenaviral host species make zoonoses possible.
H. Choe +4 more
semanticscholar +3 more sources
Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses [PDF]
Nature, 2007 At least five arenaviruses cause viral haemorrhagic fevers in humans. Lassa virus, an Old World arenavirus, uses the cellular receptor α-dystroglycan to infect cells.
S. Radoshitzky +11 more
semanticscholar +3 more sources