Results 21 to 30 of about 1,271,098 (176)

Innate Immune Response to Arenaviral Infection: A Focus on the Highly Pathogenic New World Hemorrhagic Arenaviruses

Journal of Molecular Biology, 2013
Arenaviruses are enveloped, negative-stranded RNA viruses that belong to the family Arenaviridae. This diverse family can be further classified into OW (Old World) and NW (New World) arenaviruses based on their antigenicity, phylogeny, and geographical ...
T. Koma, Cheng Huang, Olga A. Kolokoltsova, A. Brasier, S. Paessler   +4 more
semanticscholar   +3 more sources

Entry inhibitors as arenavirus antivirals [PDF]

Frontiers in Microbiology
Arenaviruses belonging to the Arenaviridae family, genus mammarenavirus, are enveloped, single-stranded RNA viruses primarily found in rodent species, that cause severe hemorrhagic fever in humans. With high mortality rates and limited treatment options,
Kruthika Iyer, Zhonghao Yan, Susan R. Ross   +2 more
doaj   +2 more sources

Glycoprotein-Specific Polyclonal Antibodies Targeting Machupo Virus Protect Guinea Pigs against Lethal Infection [PDF]

Vaccines
Convalescent plasma has been shown to be effective at protecting humans against severe diseases caused by New World (NW) arenaviruses, including Junin virus (JUNV) and Machupo virus (MACV).
Joseph W. Golden, Steven A. Kwilas, Jay W. Hooper   +2 more
doaj   +2 more sources

Lifecycle modelling systems support inosine monophosphate dehydrogenase (IMPDH) as a pro‐viral factor and antiviral target for New World arenaviruses

Antiviral Research, 2018
Infection with Junín virus (JUNV) is currently being effectively managed in the endemic region using a combination of targeted vaccination and plasma therapy.
E. Dunham, A. Leske, Kyle Shifflett, A. Watt, H. Feldmann, T. Hoenen, A. Groseth   +6 more
semanticscholar   +3 more sources

Identification and characterization of potent small molecule inhibitor of hemorrhagic fever New World arenaviruses

Antiviral Research, 2005
Category A arenaviruses as defined by the National Institute of Allergy and Infectious Diseases (NIAID) are human pathogens that could be weaponized by bioterrorists.
T. Bolken, S. Laquerre, Yuanming Zhang, T. Bailey, D. Pevear, Shirley S. Kickner, Lindsey Sperzel, Kevin F. Jones, Travis K Warren, S. Amanda Lund, Dana L Kirkwood-Watts, David S. King, A. Shurtleff, M. Guttieri, Yijun Deng, Maureen R. Bleam, D. Hruby   +16 more
semanticscholar   +3 more sources

A MOPEVAC multivalent vaccine induces sterile protection against New World arenaviruses in non-human primates

Nature Microbiology, 2023
Pathogenic New World arenaviruses (NWAs) cause haemorrhagic fevers and can have high mortality rates, as shown in outbreaks in South America. Neutralizing antibodies (Abs) are critical for protection from NWAs. Having shown that the MOPEVAC vaccine, based on a hyperattenuated arenavirus, induces neutralizing Abs against Lassa fever, we hypothesized ...
S. Reynard, Xavier Carnec, C. Picard, Virginie Borges-Cardoso, Alexandra Journeaux, M. Mateo, Clara Germain, Jimmy Hortion, Laure Albrecht, Émeline Perthame, N. Pietrosemoli, Audrey Vallvé, Stéphane Barron, Aurélie Duthey, Orianne Lacroix, Ophélie Jourjon, Marie Moroso, L. Fellmann, Pierre-Henri Moreau, M. Daniau, Catherine Legras-Lachuer, Manon Dirheimer, C. Carbonnelle, H. Raoul, S. Baize   +24 more
semanticscholar   +4 more sources

Discovery and biological confirmation of a highly divergent Tacaribe virus in metatranscriptomic data from neotropical bats [PDF]

mSphere
First isolated from neotropical fruit bats in Trinidad in 1956, Tacaribe virus (TCRV) has rarely been detected since. We searched for New World arenavirus reads in roughly 5.7 million sequencing runs available on public databases using Serratus.
Carlo Fischer, Murilo Henrique Anzolini Cassiano, William R. Thomas, Liliana M. Dávalos, Yolanda Leon, Jackeline Salazar, Stephen J. Rossiter, Andres Moreira-Soto, Jan Felix Drexler   +8 more
doaj   +2 more sources

Co-circulation of Clade C New World Arenaviruses: New geographic distribution and host species.

Infection, Genetics and Evolution, 2015
Clade C, of the New World Arenaviruses, is composed of only the Latino and Oliveros viruses and, besides the geographic range of their rodent reservoirs, the distribution of these viruses has been restricted to Bolivia and Argentina. In this study, the genetic detection and phylogenetic analysis of the complete S segment sequences of sympatric ...
J. Fernandes, R. D. de Oliveira, A. Guterres, Fabiana de Carvalho Serra, C. Bonvicino, P. D’Andrea, R. V. Cunha, S. Levis, E. R. D. de Lemos   +8 more
semanticscholar   +3 more sources

Development and characterization of a reverse genetics system for the lineage II Chicava strain of Machupo virus in a guinea pig model. [PDF]

PLoS Neglected Tropical Diseases
BackgroundMachupo virus (MACV) is a New World mammarenavirus (hereafter referred to as "arenavirus") and the etiologic agent of Bolivian hemorrhagic fever (BHF).
Emily Mantlo, Junki Maruyama, John T Manning, Rachel A Reyna, Cheng Huang, Slobodan Paessler   +5 more
doaj   +2 more sources

Epidemiology and virology of New World Arenaviruses [PDF]

International Journal of Infectious Diseases, 2018
A. Sinchi
semanticscholar   +2 more sources