Results 31 to 40 of about 1,271,098 (176)

Antiviral activity of Tripartite-Motif 2 protein against New World Arenaviruses [PDF]

International Journal of Infectious Diseases, 2018
Nicolás Sarute, B. Fagla, N. Ibrahim, M. Lavanya, S. Ross   +4 more
semanticscholar   +2 more sources

Highly Pathogenic New World and Old World Human Arenaviruses Induce Distinct Interferon Responses in Human Cells [PDF]

Journal of Virology, 2015
ABSTRACT The arenavirus family includes several important pathogens that cause severe and sometimes fatal diseases in humans. The highly pathogenic Old World (OW) arenavirus Lassa fever virus (LASV) is the causative agent of Lassa fever (LF) disease in humans. LASV infections in severe cases are generally immunosuppressive without stimulating
Cheng Huang, Olga A. Kolokoltsova, Nadezhda Yun, A. Seregin, S. Ronca, T. Koma, S. Paessler   +6 more
semanticscholar   +3 more sources

Old and New World arenaviruses share a highly conserved epitope in the fusion domain of the glycoprotein 2, which is recognized by Lassa virus-specific human CD4+ T-cell clones.

Virology, 2004
Data from human studies and animal experiments indicate a dominant role of T-cells over antibodies in controlling acute Lassa virus infection and providing immunity to reinfection.
J. Meulen, Marlis Badusche, J. Satoguina, T. Strecker, O. Lenz, C. Loeliger, M. Sakho, K. Koulémou, L. Koivogui, A. Hoerauf   +9 more
semanticscholar   +3 more sources

Special Issue “Arenaviruses 2020”

Viruses, 2021
Rodent-borne arenaviruses have been traditionally predominantly associated with certain muroid species from Mastomys/Praomys genera (African arenaviruses) or with species that belong to murid subfamily Cricetidae (New World arenaviruses) [...]
Igor S. Lukashevich, Juan Carlos de la Torre   +1 more
doaj   +1 more source

Drug discovery technologies and strategies for Machupo virus and other New World arenaviruses [PDF]

Expert Opinion on Drug Discovery, 2012
Seven arenaviruses cause viral hemorrhagic fever in humans: the Old World arenaviruses Lassa and Lujo, and the New World Clade B arenaviruses Machupo (MACV), Junín (JUNV), Guanarito (GTOV), Sabiá (SABV), and Chapare (CHPV). All of these viruses are Risk Group 4 biosafety pathogens. MACV causes human disease outbreak with high case-fatality rates.
S. Radoshitzky, J. Kuhn, Fabian de Kok-Mercado, P. Jahrling, S. Bavari   +4 more
semanticscholar   +3 more sources

Different Mechanisms of Cell Entry by Human-Pathogenic Old World and New World Arenaviruses [PDF]

Journal of Virology, 2008
ABSTRACT The Old World arenavirus Lassa virus (LASV) is the causative agent of severe viral hemorrhagic fever (VHF) in humans and is the most prevalent human pathogen among arenaviruses. The present study investigated the largely unknown mechanisms of cell entry of LASV, a process know to be mediated solely by the virus envelope glycoprotein (
Jillian M. Rojek, Ana B. Sánchez, Ngoc-Phuong-Thao Nguyen, J. C. de la Torre, S. Kunz   +4 more
semanticscholar   +3 more sources

Computational and Functional Analysis of the Virus-Receptor Interface Reveals Host Range Trade-Offs in New World Arenaviruses [PDF]

Journal of Virology, 2015
ABSTRACT Animal viruses frequently cause zoonotic disease in humans. As these viruses are highly diverse, evaluating the threat that they pose remains a major challenge, and efficient approaches are needed to rapidly predict virus-host compatibility.
Scott A. Kerr, Eleisha L. Jackson, Oana I. Lungu, A. Meyer, Ann M Demogines, A. Ellington, G. Georgiou, C. Wilke, S. Sawyer   +8 more
semanticscholar   +3 more sources

Genetic detection and characterization of Lujo virus, a new hemorrhagic fever-associated arenavirus from southern Africa. [PDF]

PLoS Pathogens, 2009
Lujo virus (LUJV), a new member of the family Arenaviridae and the first hemorrhagic fever-associated arenavirus from the Old World discovered in three decades, was isolated in South Africa during an outbreak of human disease characterized by nosocomial ...
Thomas Briese, Janusz T Paweska, Laura K McMullan, Stephen K Hutchison, Craig Street, Gustavo Palacios, Marina L Khristova, Jacqueline Weyer, Robert Swanepoel, Michael Egholm, Stuart T Nichol, W Ian Lipkin   +11 more
doaj   +1 more source

Machupo virus glycoprotein determinants for human transferrin receptor 1 binding and cell entry. [PDF]

PLoS ONE, 2011
Machupo virus (MACV) is a highly pathogenic New World arenavirus that causes hemorrhagic fever in humans. MACV, as well as other pathogenic New World arenaviruses, enter cells after their GP1 attachment glycoprotein binds to their cellular receptor ...
Sheli R Radoshitzky, Lindsay E Longobardi, Jens H Kuhn, Cary Retterer, Lian Dong, Jeremiah C Clester, Krishna Kota, John Carra, Sina Bavari   +8 more
doaj   +1 more source

MOLECULAR-BIOLOGICAL PECULIARITIES OF ARENAVIRUS REPRODUCTION IN SENSITIVE CELLS

Проблемы особо опасных инфекций, 2017
The Arenaviridae family consists of a large group of single strand ambisense RNA viruses that are separated phylogenetically, serologically and geographically into Old World and New World viruses.
T. E. Sizikova, V. N. Lebedev, V. B. Pantyukhov, A. F. Andrus, S. V. Borisevich   +4 more
doaj   +1 more source