Results 81 to 90 of about 8,104 (224)
Ecologic Traits Analysis for Identifying Rodent Hosts for Arenavirus and Hepacivirus in the Americas
Biotropica, Volume 57, Issue 6, November 2025.Over half of emerging human pathogens originate from wildlife, with rodents serving as key zoonotic hosts. This study used ecological trait‐based models to identify rodent traits associated with arenavirus and hepacivirus infections and detect potential host species across the Americas, our models achieve high predictive accuracy (AUC = 0.92–0.96).
María del Carmen Villalobos‐Segura +3 more
wiley +1 more source
Nature Communications, 2018 While five arenaviruses cause human hemorrhagic fevers in the Western Hemisphere, only Junin virus (JUNV) has a vaccine. The GP1 subunit of their envelope glycoprotein binds transferrin receptor 1 (TfR1) using a surface that substantially varies in ...
L. Clark +12 more
semanticscholar +1 more source
The Biological Characteristics and Mouse Model of Lassa Virus From the First Imported Case in China
MedComm, Volume 6, Issue 8, August 2025.This is the first case of Lassa fever being introduced to China. A strain of the Lineage IV LASV was successfully isolated, and genomic and mutation analysis were conducted. Infection models were constructed using BALB/c, C57BL/6, and AG129 mice, which were successfully established.
Yanan Zhou +25 more
wiley +1 more source
Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 6, June 2025.ABSTRACT Favipiravir is a selective RNA polymerase inhibitor and a broad‐spectrum antiviral drug. Favipiravir reduces cell proliferation by inhibiting RNA transcription, particularly in rapidly proliferating cells such as spermatogonia. The aim of this study was to investigate the effects and mechanism of action of favipiravir (T‐705) on sperm quality ...
Ali Doğan Ömür +6 more
wiley +1 more source
Viruses, 2013 Viral hemorrhagic fevers (VHFs) caused by arenaviruses are acute diseases characterized by fever, headache, general malaise, impaired cellular immunity, eventual neurologic involvement, and hemostatic alterations that may ultimately lead to shock and ...
Roberto G. Pozner +3 more
doaj +1 more source
PLoS Pathogens, 2017 Many emerging infections are RNA virus spillovers from animal reservoirs. Reservoir identification is necessary for predicting the geographic extent of infection risk, but rarely are taxonomic levels below the animal species considered as reservoir, and ...
S. Gryseels +5 more
semanticscholar +1 more source
International Nursing Review, Volume 72, Issue 2, June 2025.ABSTRACT Aim To explore emergency room nurses’ perceptions of preparedness for bioterrorism. Introduction In the context of evolving global security threats, including wars, terrorism, and emerging infectious diseases, it is critical to evaluate the bioterrorism response competencies of emergency room nurses and identify strategies to enhance their ...
Mi‐Kyeong Jeon, Yujeong Kim
wiley +1 more source
Emerging virus diseases: can we ever expect the unexpected?
Emerging Microbes and Infections, 2012 Emerging virus diseases are a major threat to human and veterinary public health. With new examples occurring approximately one each year, the majority are viruses originating from an animal host.
Colin R Howard, Nicola F Fletcher
doaj +1 more source
Innate and adaptive immune control of genetically engineered live-attenuated arenavirus vaccine prototypes [PDF]
, 2017 Arenaviruses such as Lassa virus (LASV) cause significant morbidity and mortality in endemic areas. Using a glycoprotein (GP) exchange strategy, we have recently developed live-attenuated arenavirus vaccine prototypes (rLCMV/VSVG) based on lymphocytic ...
Bergthaler, Andreas +7 more
core
PLoS Pathogens, 2017 Cell entry of many enveloped viruses occurs by engagement with cellular receptors, followed by internalization into endocytic compartments and pH-induced membrane fusion.
H. Israeli +4 more
semanticscholar +1 more source