Results 61 to 70 of about 5,184 (193)

Phylogeny and evolution of old world arenaviruses

open access: yes, 2006
The intention of this study was to investigate the genomics, phylogeny and evolution of the Old World arenaviruses based on sequence data representing the four viral genes. To achieve this aim, we sequenced the complete S and L RNA segments of Ippy virus
Charrel, Rémi N.   +6 more
core   +1 more source

ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication

open access: yesAdvanced Science, Volume 13, Issue 12, 27 February 2026.
During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou   +8 more
wiley   +1 more source

Protein sequence database for pathogenic arenaviruses [PDF]

open access: yes, 2007
BackgroundArenaviruses are a family of rodent-borne viruses that cause several hemorrhagic fevers. These diseases can be devastating and are often lethal. Herein, to aid in the design and development of diagnostics, treatments and vaccines for arenavirus
Valerie Pasquetto   +13 more
core   +1 more source

Land use gradients drive spatial variation in Lassa fever host communities in the Eastern Province of Sierra Leone

open access: yesJournal of Animal Ecology, Volume 95, Issue 2, Page 296-312, February 2026.
As West Africa urbanises, the risk of Lassa fever may paradoxically decrease. We found the invasive house mouse, a dominant urban species, outcompetes and displaces the primary Lassa virus host. Considering these species interactions is critical for accurately predicting future zoonotic disease patterns.
David Simons   +13 more
wiley   +1 more source

Emerging virus diseases: can we ever expect the unexpected?

open access: yesEmerging Microbes and Infections, 2012
Emerging virus diseases are a major threat to human and veterinary public health. With new examples occurring approximately one each year, the majority are viruses originating from an animal host.
Colin R Howard, Nicola F Fletcher
doaj   +1 more source

Targeting the apical domain of the transferrin receptor: Development of a new protein scaffold for cellular delivery

open access: yesProtein Science, Volume 34, Issue 12, December 2025.
Abstract Human transferrin receptor 1 (TfR) is essential for cellular iron homeostasis by internalizing the iron carrier proteins transferrin and ferritin. It is also an entry point for various pathogens, such as South American hemorrhagic fever caused by arenaviruses and the malaria parasite Plasmodium vivax, which utilize TfR to gain access to cells.
Anuthariq Alikkam Veetil   +5 more
wiley   +1 more source

High Diversity of RNA Viruses in Rodents, Ethiopia

open access: yesEmerging Infectious Diseases, 2012
We investigated synanthropic small mammals in the Ethiopian Highlands as potential reservoirs for human pathogens and found that 2 rodent species, the Ethiopian white-footed mouse and Awash multimammate mouse, are carriers of novel Mobala virus strains ...
Yonas Meheretu   +12 more
doaj   +1 more source

Discovery of a Baloxavir‐Inspired Endonuclease Inhibitor That Prevents Herpes Simplex Virus 1 Replication in Cell Culture and In Vivo

open access: yesAdvanced Science, Volume 12, Issue 42, November 13, 2025.
Current herpesvirus treatments targeting the viral DNA polymerase are limited by toxicities and drug resistance. Novel compounds inhibiting the nuclease activity of the herpes simplex virus 1 (HSV‐1) terminase complex, required for viral genome packaging, have been identified.
Sabina Andreu   +12 more
wiley   +1 more source

The Phylogeny of New World (Tacaribe Complex) Arenaviruses

open access: yes, 1996
Several New World (Tacaribe complex) arenaviruses (Arenaviridae) are known to cause severe hemorrhagic disease in humans. Phylogenetic reconstruction of the Tacaribe complex arenaviruses previously has been limited by the relative scarcity of sequence ...
NICHOL, STUART T.   +2 more
core   +1 more source

The underlying mechanisms of arenaviral entry through matriglycan

open access: yesFrontiers in Molecular Biosciences
Matriglycan, a recently characterized linear polysaccharide, is composed of alternating xylose and glucuronic acid subunits bound to the ubiquitously expressed protein α-dystroglycan (α-DG).
Michael Katz, Ron Diskin
doaj   +1 more source

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