Results 51 to 60 of about 5,184 (193)

Plasmacytoid Dendritic Cells Exhibit High Transferrin Receptor Expression Without Iron Accumulation

European Journal of Immunology, Volume 56, Issue 6, June 2026.
• pDCs are defined by high surface TFRC expression and dynamic iron flux, distinguishing them from conventional dendritic cell subsets. • In the Iron proteome, pDC are enriched for mitochondrial heme and Fe–S proteins but have similar iron storage to cDC. • Iron chelation does not disrupt pDC type‐1 IFN production. ABSTRACT Plasmacytoid dendritic cells
Carrie Corkish, Simon O'Shaughnessy, Claire Lin, Sophia Wugk, Sarah Kenny, Linda Sinclair, Suzanne Cloonan, David Finlay   +7 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, Volume 600, Issue 10, Page 1420-1443, May 2026.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Suppression of Calcium Influx Reduces Coxsackievirus B3 Lethality With Elevated Interferon Beta Responses in Mice

Journal of Medical Virology, Volume 98, Issue 5, May 2026.
ABSTRACT The disease course of severe enterovirus (EV) infection with hepatic necrosis is usually fulminant and fatal. Coxsackievirus (CVB3) is the emerging and important serotype of newborn EV inducing hepatic necrosis. Calcium (Ca2+) regulates host immunity, type I interferon (IFN‐I), and viral infections.
Yi‐Ling Hsiao, Cheng‐Huei Hung, Ming Te Yeh, Shun‐Hua Chen   +3 more
wiley   +1 more source

Extending the Targets for Coronavirus Antivirals Beyond That of Approved Drugs: Insights From Preclinical Research

Microbial Biotechnology, Volume 19, Issue 5, May 2026.
Chemical structure of RIBOTAC inhibitor with metabolic handle binding as nucleotide analogue to SARS‐CoV‐2 RNA dependent RNA polymerase, its linker and the RNase L recruiter which binds RNase L monomers and mediates their dimerization that actives nuclease activity degrading the viral RNA.
Harald Brüssow
wiley   +1 more source

High Genetic Divergence and Recombination in Arenaviruses from the Americas

, 2002
The rodent-borne Arenaviruses are divided into two major antigenic groups: the Old World and New World complexes. Of the 15 known New World arenaviruses, four (Junin, Machupo, Sabia, and Guanarito) have been associated with hemorrhagic fever in humans ...
Archer, Angela M., Rico-Hesse, Rebeca
core   +1 more source

No measurable adverse effects of Lassa, Morogoro and Gairo arenaviruses on their rodent reservoir host in natural conditions

Parasites & Vectors, 2017
Background In order to optimize net transmission success, parasites are hypothesized to evolve towards causing minimal damage to their reservoir host while obtaining high shedding rates. For many parasite species however this paradigm has not been tested,
Joachim Mariën, Benny Borremans, Sophie Gryseels, Barré Soropogui, Luc De Bruyn, Gédéon Ngiala Bongo, Beate Becker-Ziaja, Joëlle Goüy de Bellocq, Stephan Günther, N’Faly Magassouba, Herwig Leirs, Elisabeth Fichet-Calvet   +11 more
doaj   +1 more source

AP‐1‐Targeting Decoy Oligonucleotides: Mechanisms and Therapeutic Potential as Modulators of Inflammatory Pathways

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Numerous cellular functions, such as apoptosis, proliferation, differentiation, survival, transformation and cell migration, are regulated by a crucial transcription factor called activator protein 1 (AP‐1). Growing evidence indicates that AP‐1 is involved in severe conditions like fibrosis, cancer, and organ damage, as well as inflammatory ...
Maryam Mahjoubin‐Tehran, Samaneh Rezaei, Vasily N. Sukhorukov, Amin Jalili, Prashant Kesharwani, Amirhossein Sahebkar   +5 more
wiley   +1 more source

Antivirals Targeting Coronavirus RNA‐Dependent RNA Polymerase and Main Protease: From Mechanisms of Action to Outcomes in COVID‐19 Clinical Trials

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
The target sites of COVID‐19 antivirals discussed in the present opinion paper, namely the RNA dependent RNA polymerase Nsp12 and of the main viral protease Nsp5, are indicated by a red star in the overview of the replication cycle of coronavirus SARS‐CoV‐2.
Harald Brüssow
wiley   +1 more source

The Antiviral Effect of the Chemical Compounds Targeting DED/EDh Motifs of the Viral Proteins on Lymphocytic Choriomeningitis Virus and SARS-CoV-2

Viruses, 2021
Arenaviruses and coronaviruses include several human pathogenic viruses, such as Lassa virus, Lymphocytic choriomeningitis virus (LCMV), SARS-CoV, MERS-CoV, and SARS-CoV-2.
Mya Myat Ngwe Tun, Kouichi Morita, Takeshi Ishikawa, Shuzo Urata   +3 more
doaj   +1 more source

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, Volume 36, Issue 26, 30 March 2026.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source