Results 31 to 40 of about 5,464 (148)

Characterization of non-standard viral genomes during arenavirus infections identifies prominent S RNA intergenic region deletions

mBio
Arenaviruses, a family of negative-sense RNA viruses spread by rodents, are a leading cause of severe hemorrhagic fever in humans. Due to a paucity of antivirals and vaccines for arenaviruses, there is a need to identify new mechanisms for interfering ...
Matthew Hackbart, Carolina B. López
doaj   +1 more source

Visualization of Double-Stranded RNA Colocalizing With Pattern Recognition Receptors in Arenavirus Infected Cells

Frontiers in Cellular and Infection Microbiology, 2018
An important step in the initiation of the innate immune response to virus infection is the recognition of non-self, viral RNA, including double-stranded RNA (dsRNA), by cytoplasmic pattern recognition receptors (PRRs).
Elizabeth J. Mateer, Slobodan Paessler, Cheng Huang   +2 more
doaj   +1 more source

Highly Effective xMAP Multiplex Assay for the Detection and Identification of Hemorrhagic Fever Agents, Including Ebola Virus

Проблемы особо опасных инфекций, 2015
Developed has been the oligonucleotide liquid biochip based on xMAP technology, designed for the laboratory detection of particularly dangerous viral pathogens such as Ebola and Marburg filoviruses, and Machupo , Junin, and Lassa arenaviruses.
V. A. Ternovoy, A. V. Sementsova, E. V. Chub, O. V. P’Yankov, V. B. Loktev, A. P. Agafonov   +5 more
doaj   +1 more source

High Genetic Divergence and Recombination in Arenaviruses from the Americas [PDF]

, 2002
The rodent-borne Arenaviruses are divided into two major antigenic groups: the Old World and New World complexes. Of the 15 known New World arenaviruses, four (Junin, Machupo, Sabia, and Guanarito) have been associated with hemorrhagic fever in humans ...
Archer, Angela M., Rico-Hesse, Rebeca
core   +1 more source

Highly Diverse Arenaviruses in Neotropical Bats, Brazil

Emerging Infectious Diseases, 2022
We detected arenavirus RNA in 1.6% of 1,047 bats in Brazil that were sampled during 2007–2011. We identified Tacaribe virus in 2 Artibeus sp. bats and a new arenavirus species in Carollia perspicillata bats that we named Tietê mammarenavirus.
Luiz Gustavo Bentim Góes, Carlo Fischer, Angélica Cristine Almeida Campos, Cristiano de Carvalho, Andrés Moreira-Soto, Guilherme Ambar, Adriana Ruckert da Rosa, Debora Cardoso de Oliveira, Wendy Karen Jo, Ariovaldo P. Cruz-Neto, Wagner André Pedro, Luzia Helena Queiroz, Paola Minoprio, Edison L. Durigon, Jan Felix Drexler   +14 more
doaj   +1 more source

Investigating CD8 T Cell Exhaustion in Chronic LCMV Infection by Flow Cytometry

Current Protocols, Volume 6, Issue 10, October 2026.
Abstract CD8 T cells and the process of T cell exhaustion are central topics in both basic immunology and translational research, including clinical applications. Here, we provide a comprehensive, step‐by‐step guide to investigate CD8 T cells in murine in vivo lymphocytic choriomeningitis virus (LCMV) infection models.
Dominique Stark, Marie‐Elen Tuchel, Gautier Stehli, Alessandro Genovese, Isaak Quast, Annette Oxenius   +5 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, Volume 600, Issue 17, Page 2526-2546, September 2026.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Mathematical Modeling of Pulse‐Seeded Metapopulation Dynamics for Andes Hantavirus Border Dispersal

Engineering Reports, Volume 8, Issue 9, September 2026.
A pulse‐seeded metapopulation SEIR model for Andes hantavirus maritime dispersal shows that heterogeneous quarantine compliance determines secondary outbreak risk. The weakest‐compliance country governs global containment, while uniform compliance above ∼65%$$ \sim 65\% $$ reduces the global reproduction number below unity.
Gideon K. Gogovi, Paul Chataa
wiley   +1 more source

Use of Single-Cycle Infectious Lymphocytic Choriomeningitis Virus To Study Hemorrhagic Fever Arenaviruses

, 2010
cause hemorrhagic fever (HF) disease in humans that is associated with high morbidity and significant mortality. The investigation of antiviral strategies to combat HF arenaviruses is hampered by the requirement of biosafety level 4 (BSL-4) facilities to
W. W. Shanaka I. Rodrigo, Luis Martínez-sobrido, Fever Arenaviruses, Juan C. De La Torre   +3 more
core   +1 more source

Research Direction and Science Evaluation: The Role of Coherence and Alignment

Journal of Economics &Management Strategy, Volume 35, Issue 3, Page 437-474, Fall 2026.
ABSTRACT The decisions of funding agencies greatly influence the direction of scientific research; however, our understanding of how applicants' research directions affect the selection process remains limited. In this study, we investigate how a project's coherence with a scientist's previous work and its alignment with current scientific trends ...
Charles Ayoubi, Sandra Barbosu, Michele Pezzoni, Fabiana Visentin   +3 more
wiley   +1 more source