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Virucidal Approaches for Hemorrhagic Fever Viruses [PDF]
VirusesWe have reviewed the primary literature on the virucidal efficacy of microbicidal active ingredients, formulated microbicides, and physical inactivation approaches (heat, irradiation) for hemorrhagic fever viruses (HFVs) (arenaviruses, filoviruses ...
Raymond W. Nims, M. Khalid Ijaz
doaj +2 more sources
Entry inhibitors as arenavirus antivirals [PDF]
Frontiers in MicrobiologyArenaviruses belonging to the Arenaviridae family, genus mammarenavirus, are enveloped, single-stranded RNA viruses primarily found in rodent species, that cause severe hemorrhagic fever in humans. With high mortality rates and limited treatment options,
Kruthika Iyer +2 more
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Activation of the STAT3 Signaling Pathway by the RNA-Dependent RNA Polymerase Protein of Arenavirus
Viruses, 2021 Arenaviruses cause chronic and asymptomatic infections in their natural host, rodents, and several arenaviruses cause severe hemorrhagic fever that has a high mortality in infected humans, seriously threatening public health.
Qingxing Wang +5 more
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Widespread recombination, reassortment, and transmission of unbalanced compound viral genotypes in natural arenavirus infections. [PDF]
, 2015 Arenaviruses are one of the largest families of human hemorrhagic fever viruses and are known to infect both mammals and snakes. Arenaviruses package a large (L) and small (S) genome segment in their virions.
Chang, Li-Wen +13 more
core +10 more sources
Антибиотики и Химиотерапия, 2023 The article presents an analysis of studies assessing the effectiveness of new nonspecific medications against hemorrhagic fevers caused by arenaviruses.
Т. Е. Sizikova +2 more
doaj +1 more source
Arenaviruses: Old viruses present new solutions for cancer therapy
Frontiers in Immunology, 2023 Viral-based cancer therapies have tremendous potential, especially in the context of treating poorly infiltrated cold tumors. However, in tumors with intact anti-viral interferon (IFN) pathways, while some oncolytic viruses induce strong innate and ...
Paweł Stachura +5 more
doaj +1 more source
Targeting of arenavirus RNA synthesis by a carboxamide-derivatized aromatic disulfide with virucidal activity. [PDF]
, 2013 Several arenaviruses can cause severe hemorrhagic fever (HF) in humans, representing a public health threat in endemic areas of Africa and South America.
Damonte, Elsa Beatriz +4 more
core +9 more sources
Viruses, 2022 Mastomys natalensis is the natural host of various arenaviruses, including the human-pathogenic Lassa virus. Homologous arenaviruses, defined here as those having M. natalensis as a natural host, can establish long-lasting infection in M.
Nele Marie Brinkmann +11 more
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Screening and Identification of Lujo Virus Inhibitors Using a Recombinant Reporter Virus Platform
Viruses, 2021 Lujo virus (LUJV), a highly pathogenic arenavirus, was first identified in 2008 in Zambia. To aid the identification of effective therapeutics for LUJV, we developed a recombinant reporter virus system, confirming reporter LUJV comparability with wild ...
Stephen R. Welch +9 more
doaj +1 more source
, 2007 The Arenaviridae family contains 22 recognized virus species, each of them strongly associated with a rodent species (except Tacaribe virus which is associated with a species of bat), suggesting an ancient co-evolutionary process. Although the concept of co-evolution between rodents and arenaviruses is now largely accepted, little has been uncovered in
Gonzalez, Jean-Paul +3 more
openaire +3 more sources