Results 21 to 30 of about 5,184 (193)
Reporter-Expressing, Replicating-Competent Recombinant Arenaviruses
Viruses, 2016 Several arenaviruses cause hemorrhagic fever (HF) disease in humans and pose an important public health problem in their endemic regions. To date, no Food and Drug Administration (FDA)-licensed vaccines are available to combat human arenavirus infections,
Luis Martínez-Sobrido +1 more
doaj +2 more sources
Development of a new quantitative RT-PCR to detect lymphocytic choriomeningitis virus [PDF]
Frontiers in Veterinary ScienceLymphocytic choriomeningitis virus (LCMV) is a neglected rodent-borne virus, with a worldwide distribution. The common mouse Mus musculus acts as reservoir and vector in the biological cycle of the virus.
Laura Herrero +9 more
doaj +2 more sources
Cleavage of the Glycoprotein of Arenaviruses
, 2018 The arenaviruses are a large family of emerging negative-stranded RNA viruses that include several severe human pathogens causing hemorrhagic fevers with high mortality. During the arenavirus life cycle, processing of the viral envelope glycoprotein precursor (GPC) by the cellular subtilisin kexin isozyme-1 (SKI-1)/site-1 protease (S1P) is crucial for ...
Laura Cendron +2 more
exaly +3 more sources
Two Novel Arenaviruses Detected in Pygmy Mice, Ghana
Emerging Infectious Diseases, 2013 Two arenaviruses were detected in pygmy mice (Mus spp.) by screening 764 small mammals in Ghana. The Natal multimammate mouse (Mastomys natalensis), the known Lassa virus reservoir, was the dominant indoor rodent species in 4 of 10 sites, and accounted ...
Karl C. Kronmann +7 more
doaj +2 more sources
Activation of the STAT3 Signaling Pathway by the RNA-Dependent RNA Polymerase Protein of Arenavirus
Viruses, 2021 Arenaviruses cause chronic and asymptomatic infections in their natural host, rodents, and several arenaviruses cause severe hemorrhagic fever that has a high mortality in infected humans, seriously threatening public health.
Qingxing Wang +5 more
doaj +1 more source
Антибиотики и Химиотерапия, 2023 The article presents an analysis of studies assessing the effectiveness of new nonspecific medications against hemorrhagic fevers caused by arenaviruses.
Т. Е. Sizikova +2 more
doaj +1 more source
Arenaviruses: Old viruses present new solutions for cancer therapy
Frontiers in Immunology, 2023 Viral-based cancer therapies have tremendous potential, especially in the context of treating poorly infiltrated cold tumors. However, in tumors with intact anti-viral interferon (IFN) pathways, while some oncolytic viruses induce strong innate and ...
Paweł Stachura +5 more
doaj +1 more source
Viruses, 2022 Mastomys natalensis is the natural host of various arenaviruses, including the human-pathogenic Lassa virus. Homologous arenaviruses, defined here as those having M. natalensis as a natural host, can establish long-lasting infection in M.
Nele Marie Brinkmann +11 more
doaj +1 more source
Screening and Identification of Lujo Virus Inhibitors Using a Recombinant Reporter Virus Platform
Viruses, 2021 Lujo virus (LUJV), a highly pathogenic arenavirus, was first identified in 2008 in Zambia. To aid the identification of effective therapeutics for LUJV, we developed a recombinant reporter virus system, confirming reporter LUJV comparability with wild ...
Stephen R. Welch +9 more
doaj +1 more source
, 2007 The Arenaviridae family contains 22 recognized virus species, each of them strongly associated with a rodent species (except Tacaribe virus which is associated with a species of bat), suggesting an ancient co-evolutionary process. Although the concept of co-evolution between rodents and arenaviruses is now largely accepted, little has been uncovered in
Gonzalez, Jean-Paul +3 more
openaire +3 more sources