Results 101 to 110 of about 78,666 (255)
JCI Insight, 2019 As sufficient extracellular arginine is crucial for T cell function, depletion of extracellular arginine by elevated Arginase 1 (Arg1) activity has emerged as a hallmark immunosuppressive mechanism.
Adrià-Arnau Martí Líndez +15 more
semanticscholar +1 more source
Advanced Science, EarlyView.To tackle the alarming mortality rate linked to Candida albicans infections, a synthetic lethal strategy precisely aimed at the two distinct forms of this fungus: yeast and hyphae is formulated. Ultimately, through the innovative use of macrophage membranes for drug delivery, the effectiveness of this strategy is substantially boosted while ...
Yang Gao +12 more
wiley +1 more source
Investigating the functionality of an OCT4-short response element in human induced pluripotent stem cells. [PDF]
, 2016 Pluripotent stem cells offer great therapeutic promise for personalized treatment platforms for numerous injuries, disorders, and diseases. Octamer-binding transcription factor 4 (OCT4) is a key regulatory gene maintaining pluripotency and self-renewal ...
Awe, Jason P +9 more
core +3 more sources
Journal of Clinical Investigation, 2019 The polarization of macrophages is regulated by transcription factors such as nuclear factor kappa B (NF-κB) and activator protein 1 (AP-1). In this manuscript, we delineated the role of the transcription factor Fos-related antigen 1 (Fra-1) during ...
N. Hannemann +17 more
semanticscholar +1 more source
Advanced Science, EarlyView.Uncovering a new layer of translational control, this study reveals how TRMT6/TRMT61A‐mediated tRNA‐m1A methylation drives pro‐tumorigenic senescence in colorectal cancer. By selectively enhancing ARG2 translation, this epitranscriptomic axis triggers an NF‐κB‐dependent SASP.
Tuoyang Li +17 more
wiley +1 more source
Erythrocytes From Patients With Type 2 Diabetes Induce Endothelial Dysfunction Via Arginase I.
Journal of the American College of Cardiology, 2018 BACKGROUND Cardiovascular complications are major clinical problems in type 2 diabetes mellitus (T2DM). The authors previously demonstrated a crucial role of red blood cells (RBCs) in control of cardiac function through arginase-dependent regulation of ...
Zhichao Zhou +14 more
semanticscholar +1 more source
Advanced Science, EarlyView.Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang +7 more
wiley +1 more source
Frontiers in Pharmacology, 2018 It is well known that arginase II leads to decreased synthesis of nitric oxide (NO) by competing with endothelial nitric oxide synthase (eNOS) for their same substrate L-arginine.
Qi Wang +10 more
doaj +1 more source
Advanced Science, EarlyView.Inspired by antibody‐antigen binding, this study develops an unprecedented immunoaffinity‐mimetic assembly strategy, with Peptide‐AptCD63 conjugates acting as antibody surrogates binding CD63 epitopes on mesenchymal stem cell‐derived exosomes. This creates a hierarchical microstructure intended to synergistically integrate antioxidative and anti ...
Dantong Zheng +8 more
wiley +1 more source
RETRACTED: Arginase II - a new target in the development of endothelium protectors
Регуляторные исследования и экспертиза лекарственных средств, 2018 RETRACTED ARTICLEThe article describes arginase’s role in pathogenesis of endothelial dysfunction and a number of cardio-vascular diseases. Arginase catalyzes the hydrolysis of L-arginine, the substrate for nitric oxide synthesis, to L-ornithine and urea.
V. I. Yakushev +6 more
doaj