Results 11 to 20 of about 78,666 (255)

Methylglyoxal-Modified Albumin Effects on Endothelial Arginase Enzyme and Vascular Function

Cells, 2023
Advanced glycation end products (AGEs) contribute significantly to vascular dysfunction (VD) in diabetes. Decreased nitric oxide (NO) is a hallmark in VD. In endothelial cells, NO is produced by endothelial NO synthase (eNOS) from L-arginine.
Ebaa M. Alzayadneh, Alia Shatanawi, R. William Caldwell, Ruth B. Caldwell   +3 more
doaj   +1 more source

DDR2-regulated arginase activity in ovarian cancer-associated fibroblasts promotes collagen production and tumor progression

Oncogene, 2023
Ovarian cancer has poor survival outcomes particularly for advanced stage, metastatic disease. Metastasis is promoted by interactions of stromal cells, such as cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME), with tumor cells ...
Favour A. Akinjiyan, Zainab Ibitoye, P. Zhao, Leah P. Shriver, Gary Patti, G. Longmore, K. Fuh   +6 more
semanticscholar   +1 more source

Arginase 1 is a key driver of immune suppression in pancreatic cancer

bioRxiv, 2022
An extensive fibroinflammatory stroma rich in macrophages is a hallmark of pancreatic cancer. In this disease, it is well appreciated that macrophages are immunosuppressive and contribute to the poor response to immunotherapy; however, the mechanisms of ...
Rosa E. Menjivar, Z. Nwosu, Wenting Du, Katelyn L. Donahue, Carlos E Espinoza, Kristee L Brown, Ashley Velez-Delgado, Wei Yan, Fatima Lima, Allison C Bischoff, Padma Kadiyala, D. Salas-Escabillas, H. Crawford, Filip Bednar, Eileen Carpenter, Yaqing Zhang, Christopher J. Halbrook, C. Lyssiotis, Marina Pasca di Magliano   +18 more
semanticscholar   +1 more source

Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages

Nature Communications, 2021
Mitochondria are important regulators of macrophage polarisation. Here, we show that arginase-2 (Arg2) is a microRNA-155 (miR-155) and interleukin-10 (IL-10) regulated protein localized at the mitochondria in inflammatory macrophages, and is critical for
J. Dowling, Remsha Afzal, L. Gearing, Mariana P. Cervantes-Silva, Stephanie Annett, Gavin M. Davis, C. de Santi, N. Assmann, K. Dettmer, D. Gough, G. Bantug, Fidinny I. Hamid, Frances K. Nally, Conor P Duffy, Aoife L Gorman, Alex Liddicoat, E. Lavelle, C. Hess, P. Oefner, David K. Finlay, G. Davey, T. Robson, Annie M. Curtis, P. Hertzog, Bryan R. G. Williams, C. McCoy   +25 more
semanticscholar   +1 more source

Impact of suitable control on a uniform interpretation of units for arginase assay

Biochemistry and Biophysics Reports, 2021
The arginase catalyzes the conversion of arginine into ornithine and urea. The activity of arginase serves as a critical diagnostic marker for several pathophysiological conditions.
Mishra Suman, Mishra Rajnikant
doaj   +1 more source

Nrf2 regulates the arginase 1+ microglia phenotype through the initiation of TREM2 transcription, ameliorating depression-like behavior in mice

Translational Psychiatry, 2022
The expression of the triggering receptor on myeloid cell-2 (TREM2) knockdown in microglia from the lateral habenula (LHb) reportedly induces depression-like behaviors in mice. However, the key molecular mechanism that mediates major depressive disorder (
Lujuan He, Yi Zheng, Lixuan L. Huang, Jingyi Ye, Yinyi Ye, Hanyue Luo, Xi Chen, W. Yao, Jiaxu Chen, Ji-chun Zhang   +9 more
semanticscholar   +1 more source

Inhibition of myeloid-derived suppressor cell arginase-1 production enhances T-cell-based immunotherapy against Cryptococcus neoformans infection

Nature Communications, 2022
Cryptococcosis is a potentially lethal disease that is primarily caused by the fungus Cryptococcus neoformans, treatment options for cryptococcosis are limited. Here, we show glucuronoxylomannan, the major polysaccharide component of C.
Yanan Li, Zhong-Wei Wang, Fan Li, Ling-Hong Zhou, Yanghua Jiang, Yao Yu, Hui-Hui Ma, Li-ping Zhu, J. Qu, X. Jia   +9 more
semanticscholar   +1 more source

Arginase: Biological and Therapeutic Implications in Diabetes Mellitus and Its Complications

Oxidative Medicine and Cellular Longevity, 2022
Arginase is a ubiquitous enzyme in the urea cycle (UC) that hydrolyzes L‐arginine to urea and L‐ornithine. Two mammalian arginase isoforms, arginase1 (ARG1) and arginase2 (ARG2), play a vital role in the regulation of β‐cell functions, insulin resistance
Yuanyuan Ren, Zhuozhuo Li, Wenqing Li, Xiaobin Fan, F. Han, Yaoyao Huang, Yi Yu, Lu Qian, Yuyan Xiong   +8 more
semanticscholar   +1 more source

Enhancing the Production of Therapeutic Enzyme Arginase from Lactobacillus acidophilus Using Response Surface Methodology

Brazilian Archives of Biology and Technology, 2022
Arginase plays an imperative role in the cell growth and proliferation of healthy cells under normal physiological conditions. Recently arginase has gained the sight of many researchers as it has emerged as a potential candidate for auxotrophic cancer ...
Himanshi Gautam, Neha Kumari, Saurabh Bansal   +2 more
doaj   +1 more source

Myeloid Cell-Derived Arginase in Cancer Immune Response

Frontiers in Immunology, 2020
Amino acid metabolism is a critical regulator of the immune response, and its modulating becomes a promising approach in various forms of immunotherapy.
T. Grzywa, A. Sosnowska, Paweł Matryba, Z. Rydzyńska, M. Jasiński, D. Nowis, J. Gołąb   +6 more
semanticscholar   +1 more source