Results 31 to 40 of about 65,972 (187)
Minimal ureagenesis is necessary for survival in the murine model of hyperargininemia treated by AAV-based gene therapy. [PDF]
, 2014 Hyperammonemia is less severe in arginase 1 deficiency compared with other urea cycle defects. Affected patients manifest hyperargininemia and infrequent episodes of hyperammonemia. Patients typically suffer from neurological impairment with cortical and
Cantero, G +8 more
core +2 more sources
Dectin-1 Activation Exacerbates Obesity and Insulin Resistance in the Absence of MyD88 [PDF]
, 2017 This work was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, grant numbers 11/15682-4, 12/02270-2, 15/18121-4), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Regenera INCT Process Grant 465656/2014-5 ...
Aguiar, Cristhiane Favero +25 more
core +5 more sources
Arginase as a mediator of diabetic retinopathy
Frontiers in Immunology, 2013 We have shown previously that diabetes causes increases in retinal arginase activity that are associated with impairment of endothelial cell (EC)-dependent vasodilation and increased formation of the peroxynitrite biomarker nitrotyrosine.
Chintan ePatel +10 more
doaj +1 more source
Arginase‐flotillin interaction brings arginase to red blood cell membrane [PDF]
FEBS Letters, 2006 Flotillin‐1 and arginase are both up‐regulated in red blood cell membrane of type 2 diabetic patients. For studying why the soluble arginase can bind to the membrane and whether such binding would modify arginase activity, the arginase1 and related proteins were cloned and expressed.
Jiang, Ming +5 more
openaire +2 more sources
Hypoxic Proliferation of Osteosarcoma Cells Depends on Arginase II
Cellular Physiology and Biochemistry, 2016 Background/Aims: Despite significant advancements in the diagnosis and treatment of osteosarcoma, the overall survival has remained relatively unchanged for over two decades.
Bhuvana A. Setty +5 more
doaj +1 more source
Pathogens, 2022 Arginase is a metalloenzyme that plays a central role in Leishmania infections. Previously, rosmarinic and caffeic acids were described as antileishmanial agents and as Leishmania amazonensis arginase inhibitors.
Julio Abel Alfredo dos Santos Simone Come +6 more
doaj +1 more source
Alteration of colonic excitatory tachykininergic motility and enteric inflammation following dopaminergic nigrostriatal neurodegeneration [PDF]
, 2016 Background: Parkinson's disease (PD) is frequently associated with gastrointestinal (GI) symptoms, including constipation and defecatory dysfunctions. The mechanisms underlying such disorders are still largely unknown, although the occurrence of a bowel ...
Antonioli, Luca +13 more
core +3 more sources
Role of arginase in vessel wall remodeling
Frontiers in Immunology, 2013 Arginase metabolizes the semi-essential amino acid L-arginine to L-ornithine and urea. There are two distinct isoforms of arginase, arginase I and II, which are encoded by separate genes and display differences in tissue distribution, subcellular ...
William eDurante
doaj +1 more source
Natural Products That Target the Arginase in Leishmania Parasites Hold Therapeutic Promise
Microorganisms, 2021 Parasites of the genus Leishmania cause a variety of devastating and often fatal diseases in humans worldwide. Because a vaccine is not available and the currently small number of existing drugs are less than ideal due to lack of specificity and emerging
Nicola S. Carter +7 more
doaj +1 more source
Arginase in glomerulonephritis [PDF]
Kidney International, 2002 l-Arginine is converted to nitric oxide and citrulline by the enzyme nitric oxide synthase (NOS). Its in vivo inhibition has led to the revelation of a multitude of diverse, often conflicting functions in the inflammatory melee. l-Arginine is also converted to ornithine and urea by the enzyme arginase as a part of the hepatic urea cycle.
openaire +2 more sources