Results 61 to 70 of about 78,666 (255)

Natural Products That Target the Arginase in Leishmania Parasites Hold Therapeutic Promise

Microorganisms, 2021
Parasites of the genus Leishmania cause a variety of devastating and often fatal diseases in humans worldwide. Because a vaccine is not available and the currently small number of existing drugs are less than ideal due to lack of specificity and emerging
Nicola S. Carter, Brendan D. Stamper, Fawzy Elbarbry, Vince Nguyen, Samuel Lopez, Yumena Kawasaki, Reyhaneh Poormohamadian, Sigrid C. Roberts   +7 more
doaj   +1 more source

Vitamin D3 supplementation of a high fat high sugar diet ameliorates prediabetic phenotype in female LDLR–/–and LDLR+/+mice [PDF]

, 2017
© 2017 The Authors. Immunity, Inflammation and Disease Published by John Wiley & Sons Ltd. INTRODUCTION: Fatty liver disease is prevalent in populations with high caloric intake.
Asai, Baldock, Bieghs, Bora, Cani, Chan, Chawla, Del Ben, DeLuca, Dongiovanni, Drewnowski, George, Giugliano, Glaros, Hummasti, Iwaki, Jorde, Jump, Kalra, Karbowska, Kennedy, Kheder, Kitson, Kleiner, Kraakman, Lira, Livak, Lytle, Machado, Madar, Marcotorchino, Merat, Minto, Oh, Okamoto, Parekh, Pham, Roth, Saraswathi, Schwen, Sergeev, Shu, Subramanian, Teramoto, Tintut, Vanlint, Wortsman, Wouters, Yin, Zhang, Zhang   +50 more
core   +1 more source

Disturbance of Arginase Activity and Nitric Oxide Levels in Iraqi Type 2 Diabetes Mellitus

مجلة بغداد للعلوم, 2018
This study is an attempt to find whether arginine metabolism dysregulation by arginase activity is related to hyperglycemia, followed by changes in nitric oxide (NO) generation in type 2 diabetic patients. This study includes 42 control subjects (Group I)
Baghdad Science Journal
doaj   +1 more source

Antileishmanial Activity of 4,8-Dimethoxynaphthalenyl Chalcones on Leishmania amazonensis

Antibiotics, 2022
Leishmaniasis is a neglected tropical disease caused by Leishmania species. Available therapeutic options have several limitations. The drive to develop new, more potent, and selective antileishmanial agents is thus a major goal.
Kaio Maciel de Santiago-Silva, Bruna Taciane da Silva Bortoleti, Laudicéa do Nascimento Oliveira, Fernanda Lima de Azevedo Maia, Joyce Cristina Castro, Ivete Conchon Costa, Danielle Bidóia Lazarin, James L. Wardell, Solange M. S. V. Wardell, Magaly Girão Albuquerque, Camilo Henrique da Silva Lima, Wander Rogério Pavanelli, Marcelle de Lima Ferreira Bispo, Raoni Schroeder B. Gonçalves   +13 more
doaj   +1 more source

Mechanisms involved in the remyelinating effect of sildenafil [PDF]

, 2018
Remyelination occurs in demyelinated lesions in multiple sclerosis (MS) and pharmacological treatments that enhance this process will critically impact the long term functional outcome in the disease.
Díaz-Lucena, Daniela, García, Agustina, Gutierrez-Mecinas, María, Martínez-Sánchez, José Lupicinio, Moreno, Beatriz, Pifarré, Paula   +5 more
core   +1 more source

Mouse Macrophage Arginase

Experimental Biology and Medicine, 1980
SummaryMouse peritoneal macrophages in culture released a macromolecular factor capable of inhibiting mouse L1210 lymphoma cells in vitro. The factor was proved to be arginase by several criteria. The inhibition was reversed by adding arginine or citrulline to culture, the arginine in the culture medium was consumed, and the guanido group of arginine ...
Chen, P C, Broome, J D
openaire   +2 more sources

Lipid nanoparticle-targeted mRNA therapy as a treatment for the inherited metabolic liver disorder arginase deficiency

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Systemically administered lipid nanoparticles (LNPs) targeting the liver were able to express the cytoplasmic enzyme arginase 1 (ARG1) in a conditional knockout model of ARG1 deficiency.
B. Truong, Gabriella Allegri, Xiao-Bo Liu, K. Burke, Xuling Zhu, S. Cederbaum, J. Häberle, P. Martini, G. Lipshutz   +8 more
semanticscholar   +1 more source

rIFN-γ-mediated growth suppression of platinum-sensitive and -resistant ovarian tumor cell lines not dependent upon arginase inhibition

Journal of Translational Medicine, 2003
Background Arginine metabolism in tumor cell lines can be influenced by various cytokines, including recombinant human interferon-γ (rIFN-γ), a cytokine that shows promising clinical activity in epithelial ovarian cancer (EOC).
Gallardo Stacie T, Melicharová Karolina, Patenia Rebecca, Hu Wei, Melichar Bohuslav, Freedman Ralph   +5 more
doaj   +1 more source

Serum Arginase Activity.

Experimental Biology and Medicine, 1957
SummarySerum arginase activity has been determined in 34 healthy blood donors. A mean value 0.06 ± 0.09 μmole urea formed/ml serum was found with a range of .00 to 0.36 μmole. In sera of 19 patients with proven or suspected liver disease the mean arginase activity was 1.36 with a range of .00 to 6.08 μmoles formed/ml serum under the condition of assay.
R T, MANNING, S, GRISOLIA
openaire   +2 more sources

Injectable Dual‐Network Hydrogel System for Osteochondral Repair Combining Immunomodulation, Mechanical Adaptability, and Enhanced Tissue Integration

Advanced Functional Materials, EarlyView.
A UV‐triggered injectable dual‐network hydrogel is reported as the first application of bletilla striata polysaccharide (BSP) in osteochondral repair. By integrating methacrylamide‐modified BSP and nitrobenzaldehyde‐functionalized hyaluronic acid, the system achieves immunomodulation, mechanical reinforcement, and dynamic tissue adhesion, thereby ...
Jiaming Cui, Feifei Zhou, Yuan Luo, Tao Ouyang, Huiwu Zhang, Songmiao Cheng, Qiang Li, Xu Jiang, Yingying Yu, Yicheng Wang, Hong Ming   +10 more
wiley   +1 more source