Results 111 to 120 of about 10,357 (212)

Effect of enzymatic deimination on the conformation of recombinant prion protein

, 2009
Deimination is the post-translational conversion of arginine residues to citrulline. It has been implicated as a causative factor in autoimmune diseases such as multiple sclerosis and rheumatoid arthritis and more recently, as a marker of ...
Oxley, David, Meersman, Filip, Webster, Judith, Young, Duncan S., Dear, Denise V., Bronstein, Igor, Gill, Andy   +6 more
core  

Structural studies of giardial arginine deiminase

, 2006
Recombinant giardial arginine deiminase (rADI) was characterized. The enzyme was found to have a specific activity of 12 U (mg protein)-1under at pH 7.4 and 1 mM arginine. The maximum velocity was 14.75 U (mg protein-1) and the KM was 0.167 mM. The specific activity and maximum velocity values are significantly lower than the values reported previously
openaire   +2 more sources

Pseudomonas aeruginosa mutants affected in anaerobic growth on arginine: Evidence for a four-gene cluster encoding the arginine deiminase pathway

, 1984
Pseudomonas aeruginosa PAO was able to grow in the absence of exogenous terminal electron acceptors, provided that the medium contained 30 to 40 mM L-arginine and 0.4% yeast extract. Under strictly anaerobic conditions (O2 at
Vander Wauven, Corinne, Kley-Raymann, M., Haas, Didier, Pierard, André   +3 more
core  

Molecular mechanisms and therapies for tumor inhibition through the arginine metabolism pathway

Frontiers in Oncology
Tumors are one of the major diseases leading to human death. Arginine metabolism plays an important role in tumor occurrence and metastasis. Based on the levels of arginine in tumor cells, methods such as recombinant arginine deiminase are used to reduce
Yuhang Xu, Mingxin Yu, Yi Zhang, Yiqing Jiang, Haiyan Zhu, Shujuan He, Guohua Yu, Niannian Li, Shuzhen Liu, Bin Liu   +9 more
doaj   +1 more source

Production and characterization of L-arginine deiminase therapeutic enzymefrom marine derived microbial strains

, 2021
Enzimlerin yüksek afinitede, özgül olarak hedeflerine bağlanarak katalitik aktivite göstermeleri onları terapötik amaçlı kullanım için güçlü bir alternatif haline getirmektedir.
Uysal, Nurşah
core  

Histone citrullination by protein arginine deiminase: is arginine methylation a green light or a roadblock

, 2015
At the time of publication, Paul Thompson was not yet affiliated with UMass Medical School.Protein citrullination, a once-obscure post-translational modification (PTM) of peptidylarginine, has recently become an area of significant interest because of ...
Thompson, Paul R, Fast, Walter
core   +1 more source

Arginine deprivation using pegylated arginine deiminase has activity against primary acute myeloid leukemia cells in vivo

, 2015
The strategy of enzymatic degradation of amino acids to deprive malignant cells of important nutrients is an established component of induction therapy of acute lymphoblastic leukemia.
Bonnet, Dominique, Anjos-Afonso, Fernando, Gribben, John G., Taussig, David C., Ariza-McNaughton, Linda, Cavenagh, Jamie, Grantham, Marianne, Clear, Andrew, Bomalaski, John S., Sohrabi, Fareeda, Hodby, Katharine A., Ghazaly, Essam, Liapis, Konstantinos, Miraki-Moud, Farideh, Szlosarek, Peter W.   +14 more
core   +1 more source

A comparative study on arginine metabolism by oral streptococci revealed both divergence and heterogeneity in dependence on arginine and significance of ornithine and citrulline

Journal of Oral Microbiology
Background Current understanding in arginine metabolism by streptococci is limited in species and strains.Objectives We compared the ability of several abundant oral streptococci to synthesize and assimilate arginine.Design Multiple species of oral ...
Lin Zeng
doaj   +1 more source

The MarR family regulator RmaH underlies the trade-off between acid sensitivity and antibiotic tolerance in Lactococcus lactis

Journal of Bacteriology
Microorganisms exhibit remarkable adaptability to diverse environmental stresses through transcriptional reprogramming. Here, we focused on the MarR family regulator RmaH in Lactococcus lactis, which orchestrated a pivotal trade-off: enhancing tolerance ...
Qianqian Song, Peng Zhang, Hao Wu, Hongji Zhu, Jiaheng Liu, Jianjun Qiao   +5 more
doaj   +1 more source

The Relationship of Arginine Deprivation, Argininosuccinate Synthetase and Cell Death in Melanoma

Drug Target Insights, 2007
It has been shown that melanoma cells do not express argininosuccinate synthetase (ASS) and therefore are unable to synthesize arginine from citrulline.
Niramol Savaraj, Chunjing Wu, Marcus Tien Kuo, Min You, Medhi Wangpaichitr, Carlos Robles, Seth Spector, Lynn Feun   +7 more
doaj