Results 111 to 120 of about 106,691 (213)

Drug Evaluation: Adi-Peg-20 - a Pegylated Arginine Deiminase for Arginine -Auxotrophic Cancers

, 2009
Pheonix is developing ADI-PEG-20, a PEGylated arginine deiminase for the potential treatment of hepatocellular carcinoma, for which the Food and Drug Administration (FDA) and the European Agency for the Evaluation of Medicinal Products have granted the ...
沈麗娟, SHEN, LI-JIUAN
core  

The MarR family regulator RmaH underlies the trade-off between acid sensitivity and antibiotic tolerance in Lactococcus lactis

Journal of Bacteriology
Microorganisms exhibit remarkable adaptability to diverse environmental stresses through transcriptional reprogramming. Here, we focused on the MarR family regulator RmaH in Lactococcus lactis, which orchestrated a pivotal trade-off: enhancing tolerance ...
Qianqian Song, Peng Zhang, Hao Wu, Hongji Zhu, Jiaheng Liu, Jianjun Qiao   +5 more
doaj   +1 more source

Elevated levels of citrullinated fibrinogen in patients with cancer

eJHaem
Neutrophil released peptidyl arginine deiminase 4 (PAD4) converts arginine residues on plasma proteins into citrulline. Here, we developed an assay to quantify citrullinated fibrinogen. We employed a biotin‐conjugated phenylglyoxal (biotin‐phenylglyoxal (
Tom Arfman, Valentina Zollet, Nick vanEs, Floris T. M. Bosch, Gerry A. F. Nicolaes, Nicoletta Sorvillo, Jan Voorberg   +6 more
doaj   +1 more source

The role of arginine deiminase pathway in the pathophysiology of Borrelia burgdorferi

, 2009
This item is available only to currently enrolled UTSA students, faculty or staff. To download, navigate to Log In in the top right-hand corner of this screen, then select Log in with my UTSA ID.<italic>Borrelia burgdorferi</italic>, the ...
Parker, Seth Michael
core   +1 more source

Structural studies of giardial arginine deiminase

, 2006
Recombinant giardial arginine deiminase (rADI) was characterized. The enzyme was found to have a specific activity of 12 U (mg protein)-1under at pH 7.4 and 1 mM arginine. The maximum velocity was 14.75 U (mg protein-1) and the KM was 0.167 mM. The specific activity and maximum velocity values are significantly lower than the values reported previously
openaire   +2 more sources

Hydroquinine Inhibits the Growth of Multidrug-Resistant Pseudomonas aeruginosa via the Suppression of the Arginine Deiminase Pathway Genes. [PDF]

Int J Mol Sci, 2023
Weawsiangsang S, Rattanachak N, Jongjitvimol T, Jaifoo T, Charoensit P, Viyoch J, Ross S, Ross GM, Baldock RA, Jongjitwimol J.   +9 more
europepmc   +1 more source

Inhibition of protein arginine deiminase II suppresses retinoblastoma in orthotopic transplantation in mice. [PDF]

Oncol Rep, 2023
Kim S, Song YK, Cho CS, Kim HJ, Fang S, Jo DH, Kim H.   +6 more
europepmc   +1 more source

Porphyromonas gingivalis Peptidyl Arginine Deiminase (PPAD) in the Context of the Feed-Forward Loop of Inflammation in Periodontitis. [PDF]

Int J Mol Sci, 2023
Prucsi Z, Zimny A, Płonczyńska A, Zubrzycka N, Potempa J, Sochalska M.   +5 more
europepmc   +1 more source

PADI6: What we know about the elusive fifth member of the peptidyl arginine deiminase family. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2023
Williams JPC, Walport LJ.
europepmc   +1 more source

Inhibition of protein arginine deiminase 4 prevents inflammation-mediated heart failure in arthritis. [PDF]

Life Sci Alliance, 2023
Heger LA, Schommer N, Fukui S, Van Bruggen S, Sheehy CE, Chu L, Rajagopal S, Sivanandhan D, Ewenstein B, Wagner DD.   +9 more
europepmc   +1 more source