Results 91 to 100 of about 106,691 (213)

Peptidomimetics as protein arginine deiminase 4 (PAD4) inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2014
The protein arginine deiminase 4 (PAD4) is a calcium-dependent enzyme, which catalyses the irreversible conversion of peptidyl-arginines into peptidyl-citrullines and plays an important role in several diseases such as in the rheumatoid arthritis, multiple sclerosis, Alzheimer's disease, Creutzfeldt-Jacob's disease and cancer.
TRABOCCHI, ANDREA, N. Pala, I. Krimmelbein, MENCHI, GLORIA, GUARNA, ANTONIO, M. Sechi, T. Dreker, SCOZZAFAVA, ANDREA, SUPURAN, CLAUDIU TRANDAFIR, CARTA, FABRIZIO   +9 more
openaire   +5 more sources

Salt Stress Induces Imbalanced ADI Pathway Gene Expressions in Pediococcus acidilactici Drives Citrulline Accumulation as an Ethyl Carbamate Precursor in Soy Sauce

Food Bioengineering
Citrulline is the main precursor of a carcinogen compound ethyl carbamate (EC) in soy sauce. Accumulation of citrulline is mainly related to metabolism of arginine by Pediococcus acidilactici via the arginine deiminase (ADI) pathway during soy sauce ...
Xiaodie Chen, Jiran Zhang, Haoran Chen, Fang Fang   +3 more
doaj   +1 more source

Neutrophils: Heterogeneity, Biology, Diseases, and Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
Neutrophils exhibit remarkable functional plasticity and play dual roles in tissue protection and disease progression. This review summarizes their key biological functions and highlights the shift from conventional broad‐spectrum interventions to neutrophil‐based drug delivery systems.
Yibing Zhang, Siwen Wu, Yusi Wang, Die Hu, Li Yang   +4 more
wiley   +1 more source

Arginine deiminase inhibits cell proliferation by arresting cell cycle and inducing apoptosis

, 1999
We have previously demonstrated that arginine deiminase inhibits the proliferation of vascular endothelial cells, but the mechanisms leading to growth inhibition have remained unclear. We report here that low concentrations of arginine deiminase purified
von Recklinghausen, G., Havers, W., Zolzer, F., Gong, H., Rossler, J., Fotsis, T., Breit, S., Schweigerer, L.   +7 more
core  

Turning on and turning off the arginine deiminase system in oral streptococci

, 1998
The arginine deiminase system in oral streptococci is highly regulated. It requires induction and is repressed by catabolites such as glucose or by aeration.
Timothy M Curran, Glen C Rutherford, Robert E Marquis, Yousheng Ma   +3 more
core   +1 more source

Plots comparing the log₂ expression ratios of the arginine deiminase (ADI) and enterococcal biofilm associated pilus (Ebp) operons in DBS01.

, 2012
Plots comparing the log2 expression ratios of the arginine deiminase (ADI) and enterococcal biofilm associated pilus (Ebp) operons in DBS01.
Phillip S. Coburn (173292), Nathan Shankar (82477), Tyrrell Conway (173299), Scott M. Maddox (173285)   +3 more
core   +1 more source

From Dysbiosis to Disease: How Vaginal Microbiota Shape Group B Streptococcus Pathogenesis

ChemBioChem, Volume 27, Issue 20, 28 October 2026.
Lactobacillus crispatus plays a critical role in the vaginal microbiome. Limiting glucose shifts metabolism toward HMO consumption and amino acid metabolism. These actions enable alkali production and competition. Homeostasis, characterized by dense Lactobacilli colonization and suppression of pathogens, provides resistance to dysbiosis.
Julie A. Talbert, Steven D. Townsend
wiley   +1 more source

Ligand-based virtual screening for the discovery of inhibitors for protein arginine deiminase type 4 (PAD4)

, 2013
Protein Arginine Deiminase type 4 (PAD4) is a new therapeutic target for the treatment of rheumatoid arthritis. In this study, ligand-based virtual screening with the integration with drug repurposing strategy was applied to the discovery of PAD4 ...
Tejo, Bimo Ario, Abdul Rahman, Mohd Basyaruddin, Ballester, Pedro J., Salleh, Abu Bakar, Teo, Chian Ying, Leow, Adam Thean Chor   +5 more
core   +1 more source

Weissella halotolerans W22 combines arginine deiminase and ornithine decarboxylation pathways and converts arginine to putrescine [PDF]

, 2009
Aims: To demonstrate that the meat food strain Weissella halotolerans combines an ornithine decarboxylation pathway and an arginine deiminase (ADI) pathway and is able to produce putrescine, a biogenic amine.
Pereira, C. I., San Romao, M. V., Lolkema, J. S., Barreto Crespo, M. T., Baretto Crespo, M.   +4 more
core   +1 more source