Results 81 to 90 of about 106,691 (213)

Metabolic reprogramming of the immune response in periodontitis

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis, a highly prevalent chronic inflammatory disease, is characterized by the progressive destruction of the tooth‐supporting tissues, ultimately causing tooth loss. In recent years, the emerging field of immunometabolism has revealed that immune cell function is tightly regulated by intracellular metabolic pathways that ...
Rafael Scaf de Molon, Melissa Grant, Iain Chapple, Joao Paulo Steffens   +3 more
wiley   +1 more source

Anti-tumor activity of arginine deiminase via arginine deprivation in retinoblastoma

Oncology Reports, 2007
In spite of recent advances in the treatment of retinoblastoma, chemotherapy is still challenging in high-stage intraocular retinoblastoma or metastatic retinoblastoma. Here, we investigated whether arginine deprivation via arginine deiminase (ADI) could be a new anti-tumor therapy in retinoblastoma cells.
Jeong Hun, Kim, Jin Hyoung, Kim, Young Suk, Yu, Dong Hun, Kim, Bon-Hong, Min, Kyu-Won, Kim   +5 more
openaire   +3 more sources

Peri‐implantitis and systemic inflammation: Current evidence, biological plausibility, and research gaps

Periodontology 2000, EarlyView.
Abstract Background Peri‐implantitis is a biofilm‐associated inflammatory condition characterized by peri‐implant mucosal inflammation and progressive bone loss. The prevalence of peri‐implantitis continues to rise among patients with dental implants. Although peri‐implantitis and periodontitis share similar inflammatory phenotypes, histopathological ...
Yumeng Yan, Jeanie Suvan, Francesco D'Aiuto   +2 more
wiley   +1 more source

Arginine deiminase gene therapy for disordered proteins

, 2019
The invention relates to compositions comprising arginine deiminase and their use in a method of reducing aggregation of disordered protein in a ...
Nash, Kevin Ron, Lee, Daniel C.
core  

Pegylated arginine deiminase: a novel anticancer enzyme agent

, 2006
Pegylated arginine deiminase (ADI-PEG20) is a novel anticancer enzyme that produces depletion of arginine, which is a nonessential amino acid in humans.
Feun, Lynn, Savaraj, Niramol
core   +1 more source

The arcABDC gene cluster, encoding the arginine deiminase pathway of Bacillus licheniformis, and its activation by the arginine repressor ArgR

, 1998
The arginine deiminase pathway enables Bacillus licheniformis to grow anaerobically on arginine. Both the presence of arginine and anaerobiosis are needed to trigger induction of the pathway.
Maghnouj, Abdelouahid, De Sousa Cabral, Tiago Franco, Stalon, Victor, Vander Wauven, Corinne   +3 more
core  

The role of arginine and arginine-metabolizing enzymes during Giardia - host cell interactions in vitro [PDF]

, 2013
Background: Arginine is a conditionally essential amino acid important in growing individuals and under nonhomeostatic conditions/disease. Many pathogens interfere with arginine-utilization in host cells, especially nitric oxide (NO) production, by ...
Stadelmann, Britta, Andersson, Mattias K, Svärd, Staffan G., Britta Stadelmann, Kurt Hanevik, Bruserud, Oystein, Hanevik, Kurt, Andersson, Mattias K.,, Svärd, Staffan G.,, Andersson, Mattias, Mattias K Andersson, Oystein Bruserud, Svärd, Staffan G, Bruserud, Øystein, Staffan G Svärd, Stadelmann, Britta,, Lundström-Stadelmann, Britta   +16 more
core   +2 more sources

Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives

JSFA reports, Volume 6, Issue 11, Page 473-489, November 2026.
Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz, Muhammad Tauseef Sultan, Muhammad Israr, Waqas Ahmad Khan, Fahad Tanveer, Muzzamal Hussain, Muhammad Imran, Ahmed Mujtaba, Anjuman Gul Memon, Muhammad Atif, Entessar Al Jbawi   +10 more
wiley   +1 more source

Obtaining recombinant arginine deiminase and determining its enzymatic activity using the modified Sakaguchi method

BACKGROUND: The development of targeted antitumor drugs is an active area of research, and the identification of new therapeutic targets and the creation of novel agents remain important challenges.
Yana A. Zabrodskaya, Alexander N. Suvorov, Natalia A. Grudinina, Elena Yu. Egidarova, Alexey V. Sokolov   +4 more
core   +1 more source

Atherosclerosis: From Pathogenesis to Therapeutic Interventions

MedComm, Volume 7, Issue 11, November 2026.
The diagram outlines the core mechanisms driving atherosclerosis, including endothelial dysfunction, inflammatory responses, phenotypic switching of smooth muscle cells, and the gut–vascular axis. It also presents the corresponding therapeutic approaches now under development, such as gene therapies, immunotherapies, and nanotechnology platforms ...
Enge Zhou, Chenxi Zhan, Yuting Li, Yi Zeng, Renfei Luo, Xin Ouyang, Shixing Liu, Renqiang Yang, Nianlong Yan, Long Jiang   +9 more
wiley   +1 more source