Results 71 to 80 of about 10,357 (212)

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

Multi-omics analysis reveals neutrophil heterogeneity and key molecular drivers in sepsis-associated acute kidney injury

Frontiers in Immunology
Sepsis-associated acute kidney injury is a critical condition driven by immune dysregulation, particularly involving neutrophils, yet their heterogeneity and molecular contributions remain underexplored.
Tianle Cheng, Yong Xu, Ziwei Liu, Yanchen Wang, Ze Zhang, Wenlin Huang   +5 more
doaj   +1 more source

Thioredoxin Modulates Protein Arginine Deiminase 4 (PAD4)-Catalyzed Citrullination

Frontiers in Immunology, 2019
Protein citrullination is a post-translational modification catalyzed by the protein arginine deiminases (PADs). This modification plays a crucial role in the pathophysiology of numerous autoimmune disorders including RA.
Mitesh Nagar, Mitesh Nagar, Ronak Tilvawala, Ronak Tilvawala, Paul R. Thompson, Paul R. Thompson   +5 more
doaj   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Transcriptome analysis shows activation of the arginine deiminase pathway in Lactococcus lactis as a response to ethanol stress [PDF]

, 2017
This paper describes the molecular response of Lactococcus lactis NZ9700 to ethanol. This strain is a well-known nisin producer and a lactic acid bacteria (LAB) model strain.
González, Miriam, Solopova, A., Díez, Lorena, Ana Solopova, Oscar P. Kuipers, Kuipers, O. P., Díez, L., Tenorio, Carmen, González-Lázaro, Miriam, Kuipers, Oscar P; id_orcid, González, M. [0000-0003-3919-2479], Fernanda Ruiz-Larrea, Tenorio, C. [0000-0002-8099-1208], Lorena Díez, Carmen Tenorio, Miriam González, Kuipers, O.P., Fernández-Pérez, R. [0000-0002-8543-788X], Kuipers, Oscar P, Fernández-Pérez, Rocío, Ruiz-Larrea, Fernanda, Solopova, Ana, Rocío Fernández-Pérez, Ruiz-Larrea, F. [0000-0001-5610-7745]   +23 more
core   +1 more source

Driving arginine catabolism to activate systemic autophagy

Autophagy Reports, 2022
Macroautophagy/autophagy is a conserved cellular self-digestive mechanism to catabolize superfluous or damaged cellular components to maintain cell homeostasis.
Yiming Zhang, Brian N. Finck, Brian J. DeBosch   +2 more
doaj   +1 more source

Arginine deiminase system and acid adaptation of oral streptococci [PDF]

Applied and Environmental Microbiology, 1995
Streptococcus rattus FA-1 and Streptococcus sanguis NCTC 10904 underwent phenotypic acid adaptation in batch cultures toward the end of sugar-fueled growth after the culture pH had dropped to triggering values. The bacteria could be derepressed or induced for arginine deiminase independently of acid adaptation, and arginolysis afforded protection ...
T M, Curran, J, Lieou, R E, Marquis
openaire   +2 more sources

Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases

Periodontology 2000, EarlyView.
Abstract Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to manage patients with both periodontitis and RA. This review seeks to provide an update on interventional and mechanistic investigations, including a brief summary of European Research programs investigating the link between periodontitis and RA. Recent
Isabel Lopez‐Oliva, Jennifer Malcolm, Shauna Culshaw   +2 more
wiley   +1 more source

Regulation of the Arginine Deiminase System by ArgR2 Interferes with Arginine Metabolism and Fitness of Streptococcus pneumoniae

mBio, 2014
Streptococcus pneumoniae is auxotrophic for arginine, and molecular analysis of the pneumococcal genome showed that the gene encoding an arginine-ornithine antiporter (ArcD) is organized in a cluster together with the arcABC genes encoding the arginine ...
Christian Schulz, Philipp Gierok, Lothar Petruschka, Michael Lalk, Ulrike Mäder, Sven Hammerschmidt   +5 more
doaj   +1 more source

Evaluation of l-arginine supplement on the growth rate, biofilm formation, and antibiotic susceptibility in Streptococcus mutans

European Journal of Medical Research, 2022
Introduction Bacteria associated with dental caries have a high ability to produce organic acids from dietary carbohydrates during growth and metabolism under acidic conditions.
Samaneh Vaziriamjad, Mobina Solgi, Farideh Kamarehei, Fatemeh Nouri, Mohammad Taheri   +4 more
doaj   +1 more source