Studies on complementation in argininosuccinate synthetase and argininosuccinate lyase deficiencies in human fibroblasts [PDF]
Human Genetics, 1981 Complementation tests after polyethylene glycol fusion have been performed between 10 citrullinemic strains with argininosuccinate synthetase deficiency and between five strains with argininosuccinate lyase deficiency. No complementation was observed between the citrullinemic strains, while two groups of complementation were defined with the ...
L, Cathelineau +3 more
core +7 more sources
An assay for argininosuccinate synthetase in Neurospora [PDF]
Fungal Genetics Reports, 1965 An assay for argininosuccinate synthetase in ...
D. E. Wampler, J. L. Fairley
openaire +3 more sources
Expression of recombinant human argininosuccinate synthetase in Escherichia coli [PDF]
Біологічні студії, 2011 Escherichia coli strain BL21(DE3)/pET42a/ASS – an efficient producer of recombinant human argininosuccinate synthetase (rhASS) – was constructed, and preparations of purified rhASS were obtained using His-tag affinity chromatography.
O. I. Vovk +3 more
doaj +2 more sources
Argininosuccinate synthetase and argininosuccinate lyase: two ornithine cycle enzymes from Agaricus bisporus [PDF]
Mycological Research, 2007 Accumulation of high quantities of urea in fruiting bodies is a known feature of larger basidiomycetes. Argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL) are two ornithine cycle enzymes catalysing the last two steps in the arginine biosynthetic pathway. Arginine is the main precursor for urea formation.
Wagemaker, M.J.M. +6 more
openaire +7 more sources
The Relationship of Arginine Deprivation, Argininosuccinate Synthetase and Cell Death in Melanoma
Drug Target Insights, 2007 It has been shown that melanoma cells do not express argininosuccinate synthetase (ASS) and therefore are unable to synthesize arginine from citrulline.
Niramol Savaraj +7 more
doaj +3 more sources
International Journal of Medical Sciences, 2010 Nitric oxide is postulated to be involved in the pathophysiology of neurological disorders due to hypoxia/ anoxia in brain due to increased release of glutamate and activation of N-methyl-D-aspartate receptors.
M. Swamy, Mohd Jamsani Mat Salleh, K. N .S. Sirajudeen, Wan Roslina Wan Yusof, G. Chandran
doaj +1 more source
Targeting Argininosuccinate Synthetase in Cancer Therapy
, 2011 There has been renewed interest in amino acid deprivation to treat various human cancers. Certain tumors do not express argininosuccinate synthetase (ASS) and therefore are unable to synthesize arginine from citrulline. These tumors are auxotrophic for arginine and may be inhibited by arginine deprivation.
Niramol Savaraj +6 more
openaire +2 more sources
Differential expression of argininosuccinate synthetase in serous and non-serous ovarian carcinomas. [PDF]
J Pathol Clin Res, 2015 The current standard of care for epithelial ovarian cancer does not discriminate between different histologic subtypes (serous, clear cell, endometrioid and mucinous) despite the knowledge that ovarian carcinoma subtypes do not respond uniformly to ...
Cheon DJ +8 more
europepmc +2 more sources
Dual Urea Cycle Dysfunction Caused by Coexisting Argininosuccinic Aciduria and Citrin Deficiency: Clinical, Biochemical, and Molecular Insights From an Exceptional Case. [PDF]
JIMD RepABSTRACT Dual inherited defects affecting urea cycle function are exceptionally rare. We report the first case, to our knowledge, of the coexistence of argininosuccinic aciduria (ASA) and citrin deficiency (CD). A girl born to consanguineous Tunisian parents presented at 6 months of age with recurrent seizures, vomiting, developmental delay, and severe
Zribi M +6 more
europepmc +2 more sources
Physical, cognitive, and social status of patients with urea cycle disorders in Japan
Molecular Genetics and Metabolism Reports, 2021 Urea cycle disorders (UCDs) are inherited metabolic diseases that lead to hyperammonemia. Severe hyperammonemia adversely affects the brain. Therefore, we conducted a nationwide study between January 2000 and March 2018 to understand the present status ...
Jun Kido +10 more
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