Results 111 to 120 of about 110,455,116 (191)

Endothelial cell senescence suppresses argininosuccinate synthetase 1 expression by promoter methylation while laminar shear stress rescues it by a mechanism involving KLF4

The FASEB Journal, 2012
Argininosuccinate synthetase 1 (ASS1) regulates the provision of L‐arginine to nitric oxide synthase 3 (NOS3). Previous studies demonstrated that ASS1 and NOS3 expressions were enhanced by laminar shear stress (LSS), and ASS1 but not NOS3 expression was suppressed by endothelial cell senescence, so that the impaired NO production in senescent cells ...
Yong Chool Boo, Gyeong In Mun
openaire   +1 more source

Comparison of two enzymes with similar substrate binding sites.

, 2013
The proteins involved are Serine racemase from Schizosaccharomyces pombe (2zpu, left) and Argininosuccinate synthetase from Thermus thermophilus (1kor, right).
Pier Federico Gherardini (90873), Gabriele Ausiello (10225), Manuela Helmer-Citterich (10228)   +2 more
core   +1 more source

Early prediction of phenotypic severity in Citrullinemia Type 1

Annals of Clinical and Translational Neurology, 2019
Objective Citrullinemia type 1 (CTLN1) is an inherited metabolic disease affecting the brain which is detectable by newborn screening. The clinical spectrum is highly variable including individuals with lethal hyperammonemic encephalopathy in the newborn
Matthias Zielonka, Stefan Kölker, Florian Gleich, Nicolas Stützenberger, Sandesh C. S. Nagamani, Andrea L. Gropman, Georg F. Hoffmann, Sven F. Garbade, Roland Posset, the Urea Cycle Disorders Consortium (UCDC) and the European Registry and Network for Intoxication type Metabolic Diseases (E‐IMD) Consortia Study Group   +9 more
doaj   +1 more source

Argininosuccinate synthetase as a plasma biomarker of liver injury after acetaminophen overdose in rodents and humans

, 2014
Context: New biomarkers are needed in acetaminophen (APAP) hepatotoxicity. Plasma argininosuccinate synthetase (ASS) is a promising candidate. Objective: Characterize ASS in APAP hepatotoxicity. Methods: ASS was measured in plasma from rodents and humans
McGill, Mitchell R., Curry, Steven C., Svetlov, Stanislav I., Farhood, Anwar, Cao, Mengde, Sharpe, Matthew R., Williams, C. David, Jaeschke, Hartmut, Svetlov, Archie   +8 more
core   +1 more source

Expression, Regulation and Function of Argininosuccinate Synthetase 1 in Mouse Uterus During Peri-implantation Period

, 2012
精氨酸琥珀酸合成酶（Argininosuccinatesynthetase1，Ass1）能够催化瓜氨酸（L-Citrulline）和天冬氨酸（L-Aspartate）形成精氨琥珀酸，然后在精氨琥珀酸裂解酶（Argininosuccinatelyase，Asl）的作用下，生成精氨酸（L-Arginine）和延胡索酸。由于Asl的表达量恒定，因此Ass1是生成精氨酸的限速酶。本实验利用原位杂交和Real-timePCR检测了Ass1和Asl在围着床期小鼠子宫中的表达 ...
黄祝
core  

Pseudodendritic keratitis in citrullinemia; a report of an unusual and novel ocular finding in this metabolic disorder

American Journal of Ophthalmology Case Reports
Purpose: To report a 15 year old girl with citrullinemia type 1 and 2 accompanied by neurologic signs and symptoms and a novel ocular complaint in cornea like tyrosinemia type 2.
Davoud Amirkashani, Saeid Talebi, Mohammad Vafaei shahi, Ali Zekri, Parisa Abdi, Mahdokht Mehramiz   +5 more
doaj   +1 more source

Mutations and polymorphisms in the human argininosuccinate synthetase (ASS1) gene

, 2008
Citrullinemia type I is an autosomal recessive disorder that is caused by a deficiency of the urea cycle enzyme argininosuccinate synthetase (ASS1). Deficiency of ASS1 shows various clinical manifestations encompassing severely affected patients with ...
Engel, K, Johannes Häberle, Höhne, W, Häberle, J, Katharina Engel, Wolfgang Höhne   +5 more
core   +1 more source

Urea cycle.

, 2016
In the urea cycle the “toxin” ammonium (NH4+) is converted to non-toxic urea by five consecutive enzymatic reactions in the liver. In hepatocytes, the rate-limiting, ATP-dependent enzyme carbamoyl phosphate synthetase 1 (CPS1), which is allosterically ...
Matthias Gautschi (2608306), Tamar Stricker (2608312), Adrian Keogh (174242), Johannes Häberle (719209), Renata C. Gallagher (2608315), Alexander Laemmle (174189), Jean-Marc Nuoffer (334268), Matthias R. Baumgartner (2608309)   +7 more
core   +1 more source

Circadian disruption promotes epileptic seizures via the Ruminococcus gnavus-arginine-NOX4-ferroptosis axis

Brain Research Bulletin
Circadian rhythm disruption (CRD) exacerbates epileptic seizures, yet the underlying molecular mechanisms remain unclear. Using a pentylenetetrazol (PTZ) kindling rat model combined with continuous light exposure, we found that CRD significantly ...
Fanqi Yu, Jia He, Yan Chen, Yulan Zhu
doaj   +1 more source

Neuronal and glial coexpression of argininosuccinate synthetase and inducible nitric oxide synthase in Alzheimer disease.

, 2001
peer reviewedThe enzyme argininosuccinate synthetase (ASS) is the rate limiting enzyme in the metabolic pathway leading from L-citrulline to L-arginine, the physiological substrate of all isoforms of nitric oxide synthases (NOS).
Feinstein, Douglas L., Wiesinger, Heinrich, HENEKA, Michael, Riederer, Peter, Dumitrescu-Ozimek, Lucia, Klockgether, Thomas   +5 more
core   +1 more source