Results 101 to 110 of about 110,455,116 (191)

Arginine-Depleting Enzymes – An Increasingly Recognized Treatment Strategy for Therapy-Refractory Malignancies

Cellular Physiology and Biochemistry, 2018
Arginine auxotrophy occurs in certain tumor types and is usually caused by the silencing of argininosuccinate synthetase 1 or arginine lyase genes. Such tumors are often associated with an intrinsic chemoresistance and thus a poor prognosis.
Christin Riess, Fatemeh Shokraie, Carl Friedrich Classen, Bernd Kreikemeyer, Tomas Fiedler, Christian Junghanss, Claudia Maletzki   +6 more
doaj   +1 more source

Assessing the therapeutic potential of PDE‐5 inhibitors in adults: Insights from a multi‐omics study

Physiological Reports, Volume 14, Issue 18, September 2026.
Abstract Phosphodiesterase‐5 inhibitors have beneficial pleiotropic effects and hold promise as adjuvant treatments for cancer, dementia, and other disorders. Sixteen men and women aged 50–60 were administered daily sildenafil/tadalafil for 1 month. We characterized molecular signatures of sildenafil/tadalafil treatment via analyses and multi‐omics ...
Kristen A. McGovern, Traver J. Wright, Erik D. Marchant, Sean P. Kilroe, William J. Durham, E. Lichar Dillon, Marc M. Baum, Michael P. Kinsky, William K. Russell, Christopher S. Fry, Pratik Gongloor, Richard B. Pyles, Randall J. Urban, Blake B. Rasmussen, Melinda Sheffield‐Moore   +14 more
wiley   +1 more source

Transcript levels of genes encoding either urea cycle enzymes or enzymes in linked pathways determined at 400 ppm and 100 ppm CO₂ and standardized to PP2A.

, 2019
Data are the mean of five biological replicates ± SD. Significance was tested according to the two-tailed Student's t-test (* p2 ratios to allow this test.
Miriam Laxa (6236678), Marco Mühlenbruch (6236672), Christoph Peterhänsel (6236675), Christian Blume (6236666), Julia Ost (6236669)   +4 more
core   +1 more source

Regulation of human argininosuccinate synthetase gene expression.

, 1988
Expression of the human argininosuccinate synthetase (AS) gene is regulated in cultured cell lines. Expression of AS is repressed six-fold by growth of cells in the presence of arginine, while expression can be induced several hundred-fold by selection ...
Boyce, Frederick May, III
core   +3 more sources

Integration of metabolite and transcript data of ornithine-linked pathways.

, 2019
The squares indicate changes on both transcription and metabolic level in response to a CO2-shift from 400 ppm to 100 ppm (Student´s t-test ...
Miriam Laxa (6236678), Marco Mühlenbruch (6236672), Christoph Peterhänsel (6236675), Christian Blume (6236666), Julia Ost (6236669)   +4 more
core   +1 more source

Model of reciprocal regulation of arginase 1 (ARG1) and nitric oxide synthase 2 (NOS2).

, 2015
Downstream metabolic products (blue framed) and their association with components of inflammatory responses (red). Enzymes (blue ellipses), NOHA: N-hydroxyarginine, OAT: ornithine aminotransferase, ODC: ornithine decarboxylase, ACL: argininosuccinate ...
Frieder Hadlich (732945), Wiebke Demasius (790105), Rosemarie Weikard (82446), Christa Kühn (790106)   +3 more
core   +1 more source

Studies on nitric oxide (No), citrulline-no cycle enzmes, arginase, glutamine synthetase and oxidative status in anoxia (Hypobaric Hypoxia) and reperfusion states in rat brain [PDF]

, 2012
Nitric oxide is postulated to be involved in the pathophysiology of neurological disorders due to hypoxia/ anoxia in brain due to increased release of glutamate and activation ofNmethyl- D-aspartate receptors.
Mummedy, Swamy
core   +1 more source

Citrullinemia type 1: genetic diagnosis and prenatal diagnosis in subsequent pregnancy [PDF]

, 2013
Citrullinemia type 1 was diagnosed by tandem mass spectrometry in a full term male neonate who presented with an acute catastrophic collapse on the 3rd day of life.
Häberle, J, Jagadeesh, Sujatha, Seshadri, Suresh, Karthikeyan, G   +3 more
core   +2 more sources

Insights into the dynamic cell associated and secreted proteome of Staphylococcus aureus cultured in TSB and milk media: a proteomic analysis

BMC Microbiology
The availability of nutrients is closely linked to the protein expression profile of microorganisms. In this study, a comparative investigation has been performed to examine the expression patterns of cell associated proteins and secreted proteins in ...
Wanting Zhu, Yujing Wang, Yanxin Li, Changjiang Zang, Hongning Jiang, Qijing Du, Jun Wang, Rongbo Fan, Rongwei Han, Yongxin Yang   +9 more
doaj   +1 more source

Effects of dietary D-mannose supplementation on growth performance, intestinal digestive capacity, gut microbiota, and ammonia tolerance of largemouth bass Micropterus salmoides

Aquaculture Reports
To investigate the effects of D-mannose on the growth performance, intestinal digestion capacity, intestinal microbiota composition, and ammonia tolerance of largemouth bass, experiments were conducted using largemouth bass fry with an average body ...
Changyi Sun, Muzi Zhang, Dexiang Feng, Shidong Wang, Ming Li   +4 more
doaj   +1 more source