Results 121 to 130 of about 110,455,116 (191)

Quantitative Proteomics Provided Insights into the Protective Effects of Heat Acclimation on the Rat Hypothalamus after Exertional Heatstroke

Journal of Integrative Neuroscience
Background: The effects of heat acclimation (HA) on the hypothalamus after exertional heatstroke (EHS) and the specific mechanism have not been fully elucidated, and this study aimed to address these questions.
Fan Xv, Li-zhen Ma, Xin Li, Jin-bao Zhao, Shu-yuan Liu, Han-ding Mao, Jun Ma, Ling Xing, Li-feng Wang, Wei-jia Zhi, Qing Song   +10 more
doaj   +1 more source

NITRIC OXIDE (NO), CITRULLINE - NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN

, 2010
Nitric oxide is postulated to be involved in the pathophysiology of neurological disorders due to hypoxia/ anoxia in brain due to increased release of glutamate and activation of N-methyl-D-aspartate receptors.
M. Swamy, Mohd Jamsani Mat Salleh, K. N .S. Sirajudeen, Wan Roslina Wan Yusof, G. Chandran
core  

ASS1 Promotes Colorectal Cancer Immune Evasion Through CPT1A-Mediated S100A10 Succinylation

Frontiers in Bioscience-Landmark
Background: Colorectal cancer (CRC) progression is frequently driven by metabolic reprogramming and immune evasion. A crucial metabolic enzyme, argininosuccinate synthetase 1 (ASS1), is dysregulated in a number of malignancies; however,
Liping Sun, Daidi Fu, Heng Zhang
doaj   +1 more source

Proteomic analysis of holocarboxylase synthetase deficient-MDA-MB-231 breast cancer cells revealed the biochemical changes associated with cell death, impaired growth signaling, and metabolism

Frontiers in Molecular Biosciences
We have previously shown that the holocarboxylase synthetase (HLCS) is overexpressed in breast cancer tissue of patients, and silencing of its expression in triple-negative cancer cell line inhibits growth and migration.
Witchuda Sukjoi, Clifford Young, Mitchell Acland, Siraprapa Siritutsoontorn, Sittiruk Roytrakul, Manuela Klingler-Hoffmann, Peter Hoffmann, Sarawut Jitrapakdee   +7 more
doaj   +1 more source

Hypoxia inhibits the induction of argininosuccinate synthetase by endotoxin in lung endothelial cells

, 1997
Pulmonary artery endothelial cells (PAEC) possess a two-step pathway for synthesizing L-arginine from L-citrulline. The first and rate-limiting step is catalyzed by argininosuccinate synthetase (AS).
E. R. Block, Y. Su
core   +1 more source

X-ray crystallographic studies of argininosuccinate synthetase

, 2002
Argininosuccinate synthetase (AS) is the rate-limiting enzyme of both the urea and arginine-citrulline cycles. In mammals, deficiency of AS leads to citrullinemia, a debilitating and often fatal autosomal recessive urea cycle disorder, whereas its ...
Lemke, Christopher Tony
core   +1 more source

Argininosuccinate Synthetase 1 Loss in Invasive Bladder Cancer Regulates Survival through General Control Nonderepressible 2 Kinase-Mediated Eukaryotic Initiation Factor 2α Activity and Is Targetable by Pegylated Arginine Deiminase. [PDF]

Am J Pathol, 2017
Sahu D, Gupta S, Hau AM, Nakashima K, Leivo MZ, Searles SC, Elson P, Bomalaski JS, Casteel DE, Boss GR, Hansel DE.   +10 more
europepmc   +1 more source

The arginine synthetase pathway is responsible for carbamoyl phosphate synthesis in <i>Thermococcus kodakarensis</i>. [PDF]

Front Microbiol
Michimori Y, Ohashi N, Szymanski C, Atomi H.   +3 more
europepmc   +1 more source

Metabolic Engineering of Pichia pastoris for S-Adenosylmethionine Overproduction via Transcriptomic-Guided Energy Reallocation. [PDF]

Biotechnol J
Shang YY, Li ZY, Wu JM, Yang H, Lian Z, Zhu HY, Qian JC, Xu F, Huang MZ.   +8 more
europepmc   +1 more source

Pre-emptive treatment in later-onset urea cycle disorders: a clinical perspective on glycerol phenylbutyrate. [PDF]

Orphanet J Rare Dis
Spada M, Porta F.
europepmc   +1 more source