Results 81 to 90 of about 110,455,116 (191)

Inhibition or promotion, the potential role of arginine metabolism in immunotherapy for colorectal cancer

All Life, 2023
Colorectal cancer (CRC) is the third most common cancer in the world, with increasing morbidity and mortality. The current diagnosis and treatment plan rely on early detection and comprehensive treatment based on surgery.
Chengyang Chen, Xia Jiang, Zengren Zhao
doaj   +1 more source

Supplementary Figure 3 from Prognostic and Therapeutic Impact of Argininosuccinate Synthetase 1 Control in Bladder Cancer as Monitored Longitudinally by PET Imaging

, 2023
<p>PDF file - 315K, Immunostaining of ASS1, TS, and DHFR in representative urothelial carcinomas.</p>
Peter W. Szlosarek, Chien-Feng Li, Norbert Avril, Jane Sosabowski, Julie Foster, Stephen Mather, Nicholas R. Lemoine, Tim Crook, Yong-Jie Lu, Robert C. Jackson, John S. Bomalaski, Bor-Wen Wu, Claude Chelala, Louise J. Jones, Luis Beltran, Christian Frezza, David Neal, Anne Y. Warren, Hayley C. Whitaker, Rebecca Roylance, Ian Tomlinson, Malgorzata Chmielewska-Kassassir, Laura Lattanzio, Cristiana Lo Nigro, Nelofer Syed, Ming Yuan, Rosalind Cutts, Essam Ghazaly, Barbara Delage, Julius Leyton, Chantelle Hudson, Phuong Luong, Michael D. Allen   +32 more
openaire   +1 more source

Targeting Argininosuccinate Synthetase in Cancer Therapy

, 2011
There has been renewed interest in amino acid deprivation to treat various human cancers. Certain tumors do not express argininosuccinate synthetase (ASS) and therefore are unable to synthesize arginine from citrulline.
Dinh, Vy, You, Min, Wangpaichitr, Medhi, Feun, Lynn, Savaraj, Niramol, Kuo, Macus Tien, Wu, Chunjing   +6 more
core   +1 more source

Arginine Deprivation in SCLC: Mechanisms and Perspectives for Therapy

Lung Cancer: Targets and Therapy, 2022
Joséphine Carpentier,1 Iuliia Pavlyk,1 Uma Mukherjee,2 Peter E Hall,2 Peter W Szlosarek1,2 1Centre for Cancer Biomarkers and Biotherapeutics, Barts Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, UK; 2Department of Medical Oncology ...
Carpentier J, Pavlyk I, Mukherjee U, Hall PE, Szlosarek PW   +4 more
doaj  

Finding My Path: Listening, Learning, and Leading in Rare Disease: The 2025 Hower Award

Annals of the Child Neurology Society, EarlyView.
Andrea Gropman
wiley   +1 more source

Gastric Cancer: Epidemiology, Risk Factors, Pathogenesis, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
This comprehensive review summarizes gastric cancer epidemiology, multifactorial risk factors (like infectious, dietary, genetic), pathogenesis such as precancerous evolution, molecular alterations, and a focus on the bidirectional interactions between gastric cancer cells and macrophages in the tumor microenvironment.
Yixuan Xin, Xingya Wang, Yangtao Wu, Qian Liu, Qian Ren, Hui Wang, Jingbo Zhai   +6 more
wiley   +1 more source

Sequences of the genes encoding argininosuccinate synthetase in Escherichia coli and Saccharomyces cerevisiae: comparison with methanogenic archaebacteria and mammals

, 1990
The nucleotide (nt) sequences of the genes encoding argininosuccinate synthetase synthetase from Escheria coli K-12 (argG) and Saccharomyces cerevisiae (ARG1) were determined.
Stalon, Victor, Van Vliet, Françoise, Nakamura, Yusuke, Glansdorff, Nicolas, Falmagne, Paul, Crabeel, Marjolaine, Tricot, Catherine, Baumberg, Simon, Boyen, Anne   +8 more
core   +1 more source

Supplementary Figure Legend from Prognostic and Therapeutic Impact of Argininosuccinate Synthetase 1 Control in Bladder Cancer as Monitored Longitudinally by PET Imaging

, 2023
<p>PDF file - 65K</p>
Peter W. Szlosarek, Chien-Feng Li, Norbert Avril, Jane Sosabowski, Julie Foster, Stephen Mather, Nicholas R. Lemoine, Tim Crook, Yong-Jie Lu, Robert C. Jackson, John S. Bomalaski, Bor-Wen Wu, Claude Chelala, Louise J. Jones, Luis Beltran, Christian Frezza, David Neal, Anne Y. Warren, Hayley C. Whitaker, Rebecca Roylance, Ian Tomlinson, Malgorzata Chmielewska-Kassassir, Laura Lattanzio, Cristiana Lo Nigro, Nelofer Syed, Ming Yuan, Rosalind Cutts, Essam Ghazaly, Barbara Delage, Julius Leyton, Chantelle Hudson, Phuong Luong, Michael D. Allen   +32 more
openaire   +1 more source

Arginine deprivation therapy for malignant melanoma

Clinical Pharmacology: Advances and Applications, 2012
Jung-Ki Yoon,1,2 Arthur E Frankel,3 Lynn G Feun,4 Suhendan Ekmekcioglu,1 Kevin B Kim11Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;&nbsp;2Hwasung Public Health Center, Hwasung, South ...
Yoon JK, Frankel AE, Feun LG, Ekmekcioglu S, Kim KB   +4 more
doaj  

Inhibition of Tumor Microenvironment-Driven JAK-STAT Signaling Enhances Response to Arginine Deprivation Therapy in Triple-Negative Breast Cancer

Cells
Argininosuccinate synthetase 1 (ASS1) expression and arginine availability are key metabolic determinants that influence tumor fitness and regulate immune interactions within the tumor microenvironment (TME).
Hila Tishler, Shahar Ziman, Kuoyuan Cheng, Kun Wang, Neel Sanghvi, Lital Adler, Gil Stelzer, Hillary Maniriho, Bareket Dassa, Elizabeta Bab-Dinitz, Michal Levi, Sivan Galai, Omer Goldman, Yarden Ariav, Naama Darzi, Saar Ezagouri, Nitsan Nimni, Nataly Rosenfeld, Ron Rotkopf, Alexander Brandis, Tevie Mehlman, Roni Oren, Mirie Zerbib, Yuri Kuznetsov, Sara Donzelli, Giovanni Blandino, Rony Seger, Eytan Ruppin, Ayelet Erez   +28 more
doaj   +1 more source