, 2010 Supplementary Tables S1 & S2 from Reduced Argininosuccinate Synthetase Is a Predictive Biomarker for the Development of Pulmonary Metastasis in Patients with ...
Reiko Satow (14926212) +14 more
core +2 more sources
Expression of recombinant human argininosuccinate synthetase in Escherichia coli [PDF]
, 2011 Escherichia coli strain BL21(DE3)/pET42a/ASS – an efficient producer of recombinant human argininosuccinate synthetase (rhASS) – was constructed, and preparations of purified rhASS were obtained using His-tag affinity chromatography.
H. G. Pereverzeva +7 more
core +1 more source
A PHASE I EXPANSION STUDY OF PEGARGIMINASE, CISPLATIN AND PEMETREXED IN ARGININOSUCCINATE SYNTHETASE 1-NEGATIVE RECURRENT HIGH GRADE GLIOMAS (HGGS) [PDF]
Neuro Oncol, 2018 e14085Background: Patients (pts) with recurrent HGGs are usually managed with alkylating chemotherapy +/- bevacizumab. However, prognosis remains poor with an overall survival (OS) of 7-9 months.
Hall P +20 more
europepmc +4 more sources
Histopathology, 2023 AimsThe reliable classification of type A versus type B3 thymomas has prognostic and therapeutic relevance, but can be problematic due to considerably overlapping morphology. No immunohistochemical markers aiding in this distinction have been published so far.Methods and resultsWe identified and quantified numerous differentially expressed proteins ...
Felix Bremmer +10 more
openaire +3 more sources
Endothelial Argininosuccinate Synthetase 1 Regulates Nitric Oxide Production and Monocyte Adhesion under Static and Laminar Shear Stress Conditions [PDF]
Journal of Biological Chemistry, 2011 Laminar shear stress (LSS) is known to increase endothelial nitric oxide (NO) production, which is essential for vascular health, through expression and activation of nitric oxide synthase 3 (NOS3). Recent studies demonstrated that LSS also increases the expression of argininosuccinate synthetase 1 (ASS1) that regulates the provision of L-arginine, the
Gyeong In, Mun +3 more
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Bioengineered arginase I increases caspase-3 expression of hepatocellular and pancreatic carcinoma cells despite induction of argininosuccinate synthetase-1 [PDF]
Surgery, 2010 Hepatocellular and pancreatic carcinomas are often auxotrophic for L-arginine, a semi-essential amino acid. The purpose of this study was to investigate cancer cell death using a significantly more active, cobalt-substituted bioengineered arginase.Panc-1, a human pancreatic carcinoma cell line, and Hep 3B, a human hepatocellular carcinoma cell line ...
Evan S, Glazer +4 more
openaire +2 more sources
Unmet Needs of Parents of Children with Urea Cycle Disorders
Children, 2022 (1) Background: Phenotypic diversity and long-term health outcomes of individuals with urea cycle disorders (UCDs) have been described in detail. However, there is limited information on the burden on affected families.
Mara Scharping +8 more
doaj +1 more source
Epithelial argininosuccinate synthetase is dispensable for intestinal regeneration and tumorigenesis [PDF]
, 2021 The epithelial signaling pathways involved in damage and regeneration, and neoplastic transformation are known to be similar. We noted upregulation of argininosuccinate synthetase (ASS1) in hyperproliferative intestinal epithelium. Since ASS1 leads to de
Hakvoort, T.B.M. +33 more
core +1 more source
Differential gene expression in the liver of the African lungfish, Protopterus annectens, after 6 months of aestivation in air or 1 day of arousal from 6 months of aestivation. [PDF]
PLoS ONE, 2015 The African lungfish, Protopterus annectens, can undergo aestivation during drought. Aestivation has three phases: induction, maintenance and arousal.
Kum C Hiong +3 more
doaj +1 more source
Frontiers in Physiology, 2023 Introduction: Ammonia has been of concern for its high toxicity to animals. N-carbamylglutamate (NCG) can reduce blood ammonia levels in mammals, but studies on ammonia tolerance in fish are insufficient.Methods: Juvenile yellow catfish were fed two ...
Dexiang Feng, Zhiguo Yang, Ming Li
doaj +1 more source