Results 51 to 60 of about 110,455,116 (191)

Citrullinemia type I and hypertrophic pyloric stenosis in a 1-month old male infant

Clinics and Practice, 2013
Citrullinemia type I (CTLN1) is an inherited urea cycle disorder, now included in most newborn screening panels in the US and Europe. Due to argininosuccinate synthetase deficiency, CTLN1 can lead to recurrent hyperammonemic crisis that may result in ...
Yoona Rhee, Todd Heaton, Catherine Keegan, Ayesha Ahmad   +3 more
doaj   +1 more source

Suggested guidelines for the diagnosis and management of urea cycle disorders

Orphanet Journal of Rare Diseases, 2012
Urea cycle disorders (UCDs) are inborn errors of ammonia detoxification/arginine synthesis due to defects affecting the catalysts of the Krebs-Henseleit cycle (five core enzymes, one activating enzyme and one mitochondrial ornithine/citrulline antiporter)
Häberle Johannes, Boddaert Nathalie, Burlina Alberto, Chakrapani Anupam, Dixon Marjorie, Huemer Martina, Karall Daniela, Martinelli Diego, Crespo Pablo, Santer René, Servais Aude, Valayannopoulos Vassili, Lindner Martin, Rubio Vicente, Dionisi-Vici Carlo   +14 more
doaj   +1 more source

Supplementary Figure 1 from Prognostic and Therapeutic Impact of Argininosuccinate Synthetase 1 Control in Bladder Cancer as Monitored Longitudinally by PET Imaging

, 2023
<p>PDF file - 408K, Pyrosequencing data of bladder cancer cell lines and primary bladder cancer samples.</p>
Peter W. Szlosarek, Chien-Feng Li, Norbert Avril, Jane Sosabowski, Julie Foster, Stephen Mather, Nicholas R. Lemoine, Tim Crook, Yong-Jie Lu, Robert C. Jackson, John S. Bomalaski, Bor-Wen Wu, Claude Chelala, Louise J. Jones, Luis Beltran, Christian Frezza, David Neal, Anne Y. Warren, Hayley C. Whitaker, Rebecca Roylance, Ian Tomlinson, Malgorzata Chmielewska-Kassassir, Laura Lattanzio, Cristiana Lo Nigro, Nelofer Syed, Ming Yuan, Rosalind Cutts, Essam Ghazaly, Barbara Delage, Julius Leyton, Chantelle Hudson, Phuong Luong, Michael D. Allen   +32 more
openaire   +1 more source

Arginine Metabolism and Its Potential in Treatment of Colorectal Cancer

Frontiers in Cell and Developmental Biology, 2021
Colorectal cancer is the leading cause of death from cancer globally. The current treatment protocol still heavily relies on early detection and surgery.
Tao Du, Junyi Han
doaj   +1 more source

Data from Prognostic and Therapeutic Impact of Argininosuccinate Synthetase 1 Control in Bladder Cancer as Monitored Longitudinally by PET Imaging

, 2023
<div>Abstract<p>Targeted therapies have yet to have significant impact on the survival of patients with bladder cancer. In this study, we focused on the urea cycle enzyme argininosuccinate synthetase 1 (ASS1) as a therapeutic target in bladder cancer, based on our discovery of the prognostic and functional import of ASS1 in this setting ...
Peter W. Szlosarek, Chien-Feng Li, Norbert Avril, Jane Sosabowski, Julie Foster, Stephen Mather, Nicholas R. Lemoine, Tim Crook, Yong-Jie Lu, Robert C. Jackson, John S. Bomalaski, Bor-Wen Wu, Claude Chelala, Louise J. Jones, Luis Beltran, Christian Frezza, David Neal, Anne Y. Warren, Hayley C. Whitaker, Rebecca Roylance, Ian Tomlinson, Malgorzata Chmielewska-Kassassir, Laura Lattanzio, Cristiana Lo Nigro, Nelofer Syed, Ming Yuan, Rosalind Cutts, Essam Ghazaly, Barbara Delage, Julius Leyton, Chantelle Hudson, Phuong Luong, Michael D. Allen   +32 more
openaire   +1 more source

Citrullinemia with an atypical presentation: Paroxysmal hypoventilation attacks

Journal of Pediatric Neurosciences, 2018
Citrullinemia type 1 (CTLN1) is a rare inherited urea cycle disorder, which resulted from the deficiency of argininosuccinate synthetase enzyme. We presented an infant who was hospitalized because of acute losses of tonus and cyanotic hypoventilation ...
Zeynep Öztürk, Tuğba Hirfanoğlu, Aslı İnci, İlyas Okur, Esin Koç, Leyla Tümer, Ebru Arhan, Kürşad Aydın, Ayşe Serdaroğlu   +8 more
doaj   +1 more source

Beyond Protein Synthesis: The Multifunctional Role of Functional Amino Acids in Modulating Meat Quality in Ruminants

Animal Research and One Health, EarlyView.
Multifunctional roles of functional amino acids in regulating meat quality in ruminants: Functional amino acids (FAAs) regulate ruminant meat quality through multiple interconnected mechanisms, including antioxidant protection, metabolic regulation, signal transduction, structural support, and gene expression modulation.
Zixin Liu, Tian Xia, Xiaokang Lv, Man Ren, Chuanshe Zhou, Zhiliang Tan   +5 more
wiley   +1 more source

Expression pattern and biochemical properties of zebrafish N-acetylglutamate synthase. [PDF]

PLoS ONE, 2014
The urea cycle converts ammonia, a waste product of protein catabolism, into urea. Because fish dispose ammonia directly into water, the role of the urea cycle in fish remains unknown.
Ljubica Caldovic, Nantaporn Haskins, Amy Mumo, Himani Majumdar, Mary Pinter, Mendel Tuchman, Alison Krufka   +6 more
doaj   +1 more source

Species Dynamics and Gene Expression in Algal Polycultures Under Mixotrophic Cultivation in Outdoor Pilot‐Scale Nordic Conditions

Biotechnology and Bioengineering, EarlyView.
These results demonstrate that mixotrophic conditions drive both microbial community shifts and metabolic reprogramming, underscoring the importance of cultivation strategy and polyculture selection for targeted applications such as nutrient recovery and bioproduct generation.
Quyen Nham, Hanna Farnelid, Catherine Legrand, Elin Lindehoff   +3 more
wiley   +1 more source

Collaboration Between RSK-EphA2 and Gas6-Axl RTK Signaling in Arginine Starvation Response That Confers Resistance to EGFR Inhibitors

Translational Oncology, 2020
Many human malignancies require extracellular arginine (Arg) for survival because the key enzyme for de novo Arg biosynthesis, argininosuccinate synthetase 1 (ASS1), is silenced. Recombinant arginine deiminase (ADI-PEG20), which digests extracellular Arg,
Macus Tien Kuo, Yan Long, Wen-Bin Tsai, Ying-Ying Li, Helen H.W. Chen, Lynn G. Feun, Niramol Savaraj   +6 more
doaj   +1 more source