Results 121 to 130 of about 47,693 (305)

A small RNA response at DNA ends in Drosophila [PDF]

, 2012
Small RNAs have been implicated in numerous cellular processes, including effects on chromatin structure and the repression of transposons. We describe the generation of a small RNA response at DNA ends in Drosophila that is analogous to the recently ...
Böttcher, Romy, Förstemann, Klaus, Michalik, Katharina M.   +2 more
core   +1 more source

Highly specific enrichment of rare nucleic acid fractions using Thermus thermophilus argonaute with applications in cancer diagnostics

Nucleic Acids Research, 2019
Detection of disease-associated, cell-free nucleic acids in body fluids enables early diagnostics, genotyping and personalized therapy, but is challenged by the low concentrations of clinically significant nucleic acids and their sequence homology with ...
Jinzhao Song, Jorrit W. Hegge, M. Mauk, Junman Chen, Jacob E. Till, Neha Bhagwat, Lotte T. Azink, Jing Peng, Moen Sen, Jazmine Mays, E. Carpenter, John van der Oost, H. Bau   +12 more
semanticscholar   +1 more source

Recent advances in improving yield and immunity through transcription factor engineering

Journal of Integrative Plant Biology, EarlyView.
Recent advances have demonstrated that modulating transcription factors can help balance growth and immunity, which is critical to achieving high yield and disease resistance in crops. This review provides a perspective on how specific transcription factors can be engineered to enhance growth and immunity simultaneously. ABSTRACT Transcription factors (
Arya Bagus Boedi Iswanto, Hobin Kang, Seonyeong Park, Geon Hui Son, Sharon M. Pike, Sang Hee Kim   +5 more
wiley   +1 more source

Non‐coding RNAs in plant stress responses: molecular insights and agricultural applications

Plant Biotechnology Journal, EarlyView.
Summary Non‐coding RNAs (ncRNAs) have emerged as crucial regulators in plant responses to environmental stress, orchestrating complex networks that finetune gene expression under both abiotic and biotic challenges. To elucidate this intricate ncRNA crosstalk, this review comprehensively summarizes recent advances in understanding the mechanisms of key ...
Xiaotong Chen, Zhaohui Chen, Ryan Watts, Hong Luo   +3 more
wiley   +1 more source

Structural and biochemical insights into small RNA 3' end trimming by Arabidopsis SDN1. [PDF]

, 2018
A family of DEDDh 3'→5' exonucleases known as Small RNA Degrading Nucleases (SDNs) initiates the turnover of ARGONAUTE1 (AGO1)-bound microRNAs in Arabidopsis by trimming their 3' ends. Here, we report the crystal structure of Arabidopsis SDN1 (residues 2-
Cao, Chunyang, Chen, Jiayi, Chen, Xuemei, Gan, Jianhua, Gu, Jiaqi, Huang, Ying, Liu, Li, Ma, Jinbiao, Ruan, Wenjie, You, Chenjiang, Zhang, Lu   +10 more
core   +2 more sources

Co‐transformation using T‐DNA genes from Agrobacterium strain 82.139 enhances regeneration of transgenic shoots in Populus

Plant Biotechnology Journal, EarlyView.
Summary Barriers to transformation and regeneration continue to hamper the application of recombinant DNA‐based biotechnologies in most crops, including for gene editing. To tackle this problem, there has been increasing interest in morphogenic regulator genes, which aid in regeneration and are often plant developmental master regulator genes.
Greg S. Goralogia, Cathleen Ma, David S. Taylor, Abigail Lawrence, Victoria Conrad, Ekaterina Peremyslova, Steven H. Strauss   +6 more
wiley   +1 more source

Can we always sweep the details of RNA-processing under the carpet?

, 2013
RNA molecules follow a succession of enzyme-mediated processing steps from transcription until maturation. The participating enzymes, for example the spliceosome for mRNAs and Drosha and Dicer for microRNAs, are also produced in the cell and their copy ...
Berg, Johannes, de Meaux, Juliette, Klironomos, Filippos D.   +2 more
core   +1 more source

A petunia ethylene-responsive element binding factor, PhERF2, plays an important role in antiviral RNA silencing. [PDF]

, 2016
Virus-induced RNA silencing is involved in plant antiviral defense and requires key enzyme components, including RNA-dependent RNA polymerases (RDRs), Dicer-like RNase III enzymes (DCLs), and Argonaute proteins (AGOs).
Jiang, Cai-Zhong, Nandety, Raja Sekhar, Niu, Lixin, Reid, Michael S, Sun, Daoyang, Zhang, Yanlong   +5 more
core   +1 more source

RD21 enhances resistance to the strawberry vein banding virus by promoting autophagy‐mediated degradation of the viral silencing suppressor P6 protein

Plant Biotechnology Journal, EarlyView.
Summary Responsive to desiccation 21 (RD21) is a papain‐like cysteine protease (PLCP). PLCPs are involved in plant growth and development, as well as stress and plant immune responses. Currently, few studies have reported on the involvement of PLCPs in defence against viral infections.
Xianchu Yang, Jiying Feng, Kai Xu, Jincheng Han, Minghui Zhang, Aiwen Cheng, Zhanqi Wang, Fang Wang, Xueping Zhou, Lei Jiang, Tong Jiang   +10 more
wiley   +1 more source

MYC: The Guardian of Its Own Chaos

BioEssays, Volume 47, Issue 7, July 2025.
MYC is an oncogene that drives tumorigenesis through enhanced transcription and replication. Paradoxically, MYC induces transcriptional and replicative stress and acts as a resilience factor against these stressors. We discuss how MYC balances these stressors to promote tumor growth while evading immune detection and propose strategies to target MYC ...
Abdallah Gaballa, Bastian Krenz, Leonie Uhl   +2 more
wiley   +1 more source