Results 121 to 130 of about 43,543 (282)
Plant Biotechnology Journal, EarlyView.ABSTRACT RNA interference (RNAi) is a highly conserved gene silencing mechanism regulating gene expression at transcriptional and post‐transcriptional levels in plants. Synthetic trans‐acting small interfering RNAs (syn‐tasiRNAs) have emerged as powerful tools for highly specific and efficient gene silencing.
Ariel H. Tomassi +8 more
wiley +1 more source
A structural view of microRNA-target recognition [PDF]
, 2016 It is well established that the correct identification of the messenger RNA targeted by a given microRNA (miRNA) is a difficult problem, and that available methods all suffer from low specificity.
Leoni, Guido, Tramontano, Anna
core +1 more source
MicroRNAs‐mediated heat stress regulations in plants: Mechanisms and targets
The Plant Genome, Volume 18, Issue 4, December 2025.Abstract Heat stress, exacerbated by global warming, can cause significant challenges to agriculture, adversely impacting plant growth, reproduction, and yield. This review examines the crucial role of microRNAs (miRNAs) in mediating plant responses to heat stress across various key crops, including Arabidopsis (Arabidopsis thaliana), rice (Oryza ...
Muhammad Farooq +7 more
wiley +1 more source
Structural basis for the recognition of guide RNA and target DNA heteroduplex by Argonaute
Nature Communications, 2016 Argonaute proteins are important in the silencing machinery with some regulatory RNAs. Here, the authors solve the structure of an argonaute protein in complex with both the guide RNA and target DNA and propose a mechanism for their recognition.
Tomohiro Miyoshi +3 more
doaj +1 more source
Retrograde trafficking of Argonaute 2 acts as a rate-limiting step for de novo miRNP formation on endoplasmic reticulum–attached polysomes in mammalian cells [PDF]
, 2020 microRNAs are short regulatory RNAs in metazoan cells. Regulation of miRNA activity and abundance is evident in human cells where availability of target messages can influence miRNA biogenesis by augmenting the Dicer1-dependent processing of precursors ...
Barman, Bahnisikha +4 more
core
MINTmap: fast and exhaustive profiling of nuclear and mitochondrial tRNA fragments from short RNA-seq data. [PDF]
, 2017 Transfer RNA fragments (tRFs) are an established class of constitutive regulatory molecules that arise from precursor and mature tRNAs. RNA deep sequencing (RNA-seq) has greatly facilitated the study of tRFs.
Loher, Phillipe +2 more
core +2 more sources
Advanced Science, Volume 12, Issue 38, October 13, 2025.The apple susceptibility‐related LRR‐RLK MdRLKT21 competitively binds to fungal sRNA effectors and subsequently activates defenses by salvaging the expression of MdRLKT1 and MdRLKT2 and thereby releasing the resistance protein MdRFP1. These findings provide new insights into the molecular mechanism by which plants counteract pathogen‐secreted sRNA ...
Mingliang Lei +7 more
wiley +1 more source
Advanced Science, Volume 12, Issue 38, October 13, 2025.This study presents diPaRIS, a deep learning method designed to predict dynamic protein‐ RNA interactions with enhanced accuracy. By integrating RNA structures in vivo through a novel encoding scheme for nucleotide correlations, diPaRIS improves the interpretability of binding motifs and outperforms current state‐of‐the‐art methods across multiple ...
Lishen Zhang +5 more
wiley +1 more source
Argonaute bypasses cellular obstacles without hindrance during target search
Nature Communications, 2019 Argonaute protein is loaded with small RNA and scans long stretch of sequences to find complementary target sites. Here, using single-molecule FRET and kinetic modelling, the authors showed that prokaryotic Argonaute protein binds target DNA loosely and ...
Tao Ju Cui +6 more
doaj +1 more source