The RNA Polymerase II-associated factor 1 complex represses small-RNA-mediated heterochromatin formation and gene silencing [PDF]
, 2015 RNAi interference (RNAi) is a highly conserved regulatory mechanism employed by almost all Eukaryotes. With RNAi organisms can modulate the expression of endogenous genes and protect the integrity and identity of their genomes.
Kowalik, Katarzyna Maria
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A platform for analyzing translational control by RBPs at single-mRNA resolution in cells
Biophysics and PhysicobiologyTranslation—the process by which mRNAs are decoded into nascent peptides—is fundamental to life. This process is regulated by various RNA-binding proteins (RBPs), which interact with their target mRNAs.
Hotaka Kobayashi, Robert H. Singer
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Characterization of post-transcriptional regulatory network of RNA-binding proteins using computational predictions and deep sequencing data [PDF]
, 2013 This report is divided into three parts: Data Analysis, Mathematical Modeling and Conclusion and future directions. In the Data Analysis part, various methods and tools for characterizing the post-transcriptional regulatory networks of RNA-binding ...
Mohsen, Khorshid
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Cues from mRNA splicing prevent default Argonaute silencing in C. elegans
, 2021 Sanger sequencing data for CRISPR generated strains used in the "Cues from mRNA splicing prevent default Argonaute silencing in C.
Makeyeva, Y (via Mendeley Data) +1 more
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Cancer Medicine, Volume 15, Issue 11, November 2026.ABSTRACT Head and neck squamous cell carcinoma (HNSC) exhibits substantial molecular and morphological heterogeneity, yet current morphology‐based prognostic models often lack biological interpretability. We developed a transformer‐based computational framework (CTransPath) to virtually predict gene expression directly from hematoxylin and eosin (H&E ...
Di Zhao +5 more
wiley +1 more source
DNA interference and beyond: structure and functions of prokaryotic Argonaute proteins
Nature Communications, 2018 In this review, Aravin and colleagues examine bacterial and archaeal Argonaute proteins, discuss their diverse architectures and their possible roles in host defense, proposing additional functions for Argonaute proteins in prokaryotic cells.
Lidiya Lisitskaya +2 more
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Variation and Evolution in the Glutamine-Rich Repeat Region of Drosophila Argonaute-2
G3: Genes, Genomes, Genetics, 2016 RNA interference pathways mediate biological processes through Argonaute-family proteins, which bind small RNAs as guides to silence complementary target nucleic acids .
William H. Palmer, Darren J. Obbard
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Circular RNA SMAD4 coordinates with m6A‐dependent IGF2BP2 to promote gallbladder cancer development
Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.• circSMAD4 is upregulated in GBC and is associated with poor survival. • IGF2BP2 promotes circSMAD4 biogenesis through m6A‐dependent recognition mediated by its KH3‐KH4 domains. • circSMAD4 and IGF2BP2 reciprocally stabilize each other, forming a positive feedback loop that activates JAK2/STAT3 signalling and EMT.
Yiming Li +15 more
wiley +1 more source
Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties
, 2013 Co-author LiangMeng Wee is a student in the Interdisciplinary Graduate Program in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.MicroRNAs (miRNAs) and small interfering RNAs (siRNAs) guide Argonaute proteins to silence mRNA ...
Wee, LiangMeng +3 more
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