Results 91 to 100 of about 30,324 (235)

RNA activation in insects: From emerging evidence to molecular applications

Insect Molecular Biology, EarlyView.
Canonical RNA activation involves small RNAs interacting with promoter sequences, but there is also evidence of non‐canonical RNAa in eukaryotes. Emerging evidence suggests the presence of RNAa in insects. RNAa can be utilised as a tool for functional genomic studies in insects.
Sassan Asgari
wiley   +1 more source

RACE-Seq identifies the Argonaute-2 cleavage products of RNA interference-based oligonucleotides [PDF]

, 2018
The recent announcement of the first successful Phase III clinical trial of a RNA interference (RNAi)-based therapeutic is a major achievement in the field.
Usher, L.
core   +1 more source

Correction to “Programmable Clostridium perfringens Argonaute-Based, One-Pot Assay for the Multiplex Detection of MiRNAs”

, 2023
Correction to “Programmable Clostridium perfringens Argonaute-Based, One-Pot Assay for the Multiplex Detection of ...
Guobin Han (13161292), Haoyi Wang (8078642), Jilie Kong (1797772), Yuanwei Cao (9118680), Qiuyuan Lin (8034248), Hui Chen (28597), Wenhao Weng (4808853), Wen Sun (273647)   +7 more
core   +1 more source

Unmasking the Influence of Viral Micro‐RNAs on Host Immunity

Immunology &Cell Biology, EarlyView.
Viral micro‐RNAs are increasingly recognized as key modulators of host–virus interactions. They influence multiple immune functions, including antigen presentation, T‐cell activation, and cytokine signaling, while also tuning viral gene expression to promote persistence.
Riley J. K. Easton, Bernadette M. Saunders   +1 more
wiley   +1 more source

Domain motions of Argonaute, the catalytic engine of RNA interference

BMC Bioinformatics, 2007
Background The Argonaute protein is the core component of the RNA-induced silencing complex, playing the central role of cleaving the mRNA target. Visual inspection of static crystal structures already has enabled researchers to suggest conformational ...
Wall Michael E, Ming Dengming, Sanbonmatsu Kevin Y   +2 more
doaj   +1 more source

Efficiency of RNAi‐based gene silencing in fungi: a meta‐analysis

New Phytologist, EarlyView.
Mechanistic interpretation of RNAi efficiency across fungal lifestyles and delivery strategies based on the present meta‐analysis. Summary RNA interference (RNAi) shows great potential to protect crops against fungal diseases, yet reported protection efficiencies vary greatly, and our understanding of the factors responsible for this variance remains ...
Patrick Barth, Jakob Drumm, Alexandra Erika Schmidt, Florian Hartig, Aline Koch   +4 more
wiley   +1 more source

Argonaute2 and Argonaute4 Involved in the Pathogenesis of Kawasaki Disease via mRNA Expression Profiles

Children
Background: Argonautes (AGOs) are a type of protein that degrade specific messenger RNAs, consequently reducing the expression of a specific gene. These proteins consist of small, single-stranded RNA or DNA and may provide a route for detecting and ...
Zon-Min Lee, Hui-Chuan Chang, Shih-Feng Liu, Ying-Hsien Huang, Ho-Chang Kuo   +4 more
doaj   +1 more source

Opsoclonus‐Myoclonus‐Ataxia Revealing Underlying Neuromyelitis Optica Spectrum Disorder

Movement Disorders Clinical Practice, EarlyView.
Ana Silvia Sobreira Lima Verde, Flávia de Paiva Santos Rolim, Amanda Vale Catunda, José Orlando Ferreira Tomé Filho, Milena Sales Pitombeira, Fernanda Martins Maia Carvalho, Paula Camila Alves de Assis Pereira Matos   +6 more
wiley   +1 more source

Recent Advances in Reversed‐Phase Liquid Chromatography for Therapeutic Oligonucleotide and Conjugate Characterization: From Ion‐Pairing to Green Analytical Approaches

Analytical Science Advances, Volume 7, Issue 2, December 2026.
ABSTRACT Therapeutic oligonucleotides (ONs) have rapidly emerged as a novel class of treatments in the pharmaceutical industry, with over 25 medicines approved in the past decade. Ion‐pair reversed‐phase liquid chromatography coupled with mass spectrometry (IP‐RPLC‐MS) is widely used method for ON characterization.
Quang‐Dong Bui, Weronika Hewelt‐Belka, Tiny Deschrijver, Martin Gilar, Sebastiaan Eeltink   +4 more
wiley   +1 more source

Turning catalytically inactive human Argonaute proteins into active slicer enzymes

, 2013
Argonaute proteins interact with small RNAs that guide them to complementary target RNAs, thus leading to inhibition of gene expression. Some but not all Argonaute proteins are endonucleases and can cleave the complementary target RNA.
Janina Pfaff, Hauptmann, Judith, Pfaff, Janina, Dueck, Anne, Meister, Gunter, Simone Harlander, Anne Dueck, Rainer Merkl, Merkl, Rainer, Harlander, Simone, Gunter Meister, Judith Hauptmann   +11 more
core   +1 more source