The Hidden Architects: Nitric Oxide and Redox Dynamics in Plant Stem Cell Homeostasis
BioEssays, Volume 47, Issue 10, October 2025.This review highlights the dynamic interplay between nitric oxide (NO) and reactive oxygen species (ROS) in regulating plant stem cell renewal and differentiation. NO and ROS integrate intrinsic factors like epigenetic and hormonal signals with extrinsic cues, including environmental stress and nutrient‐TOR signaling, to maintain meristem function and ...
Jian Zeng, Xin'Ai Zhao, Jan U. Lohmann
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Tailing and degradation of Argonaute-bound small RNAs protect the genome from uncontrolled RNAi
Nature Communications, 2017 While RNA interference is a highly conserved mechanism of gene regulation, how Argonaute-bound small RNAs are targeted for degradation is not well understood.
Paola Pisacane, Mario Halic
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Rapid intraspecific evolution of miRNA and siRNA genes in the mosquito Aedes aegypti.
PLoS ONE, 2012 RNA silencing, or RNA interference (RNAi) in metazoans mediates development, reduces viral infection and limits transposon mobility. RNA silencing involves 21-30 nucleotide RNAs classified into microRNA (miRNA), exogenous and endogenous small interfering
Scott A Bernhardt +5 more
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Argonaute Protein in the Early Divergent Eukaryote Trypanosoma brucei: Control of Small Interfering RNA Accumulation and Retroposon Transcript Abundance [PDF]
, 2003 Huafang Shi +3 more
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Structure and Function of Argonaute Proteins [PDF]
Structure, 2005 Argonaute (Ago) family proteins are multidomain proteins expressed in prokaryotic and eukaryotic organisms. In eukaryotes, Ago proteins are most well known for their roles in RNA silencing. In prokaryotes, the functions of Ago proteins are unknown, but based on their similarity to eukaryotic Ago proteins, they could be involved in nucleic acid-directed
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CRISPR‐driven diagnostics: Molecular mechanisms, clinical efficacy and translational challenges
Clinical and Translational Medicine, Volume 15, Issue 10, October 2025.The CRISPR/Cas system has emerged as a transformative tool in the field of molecular diagnosis, offering unprecedented sensitivity, specificity and rapid detection capabilities. This review further examines the molecular mechanisms of CRISPR tools, compares their clinical efficacy with traditional methods and highlights cutting‐edge innovations such as
Zilong Wang +7 more
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The Arabidopsis Heterochronic Gene ZIPPY Is an ARGONAUTE Family Member [PDF]
, 2003 Christine Hunter +2 more
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A Role for ARGONAUTE in Apomixis [PDF]
The Plant Cell, 2011 Apomixis is a form of asexual reproduction in angiosperms that results in the production of viable seed from maternal tissues of the ovule in the absence of meiosis and fertilization (reviewed in [Bicknell and Koltunow, 2004][1]).
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MyomiRs Expression in Limb Girdle Muscular Dystrophy
IUBMB Life, Volume 77, Issue 10, October 2025.ABSTRACT This manuscript is a comprehensive review focused on the role of microRNAs (miRs)—short RNA molecules—in Limb Girdle Muscular Dystrophy (LGMD). LGMD encompasses various and heterogeneous rare genetic neuromuscular diseases, characterized by the progressive wasting and deterioration of muscle fibers, predominantly affecting the pelvic and ...
G. Breveglieri +7 more
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Argonaute proteins: potential biomarkers for human colon cancer
BMC Cancer, 2010 Background Although Argonaute proteins are considered to play important roles in stem cell self-renewal, RNA interference (RNAi) and translational regulation, relatively little is known about their functions in human disease.
Gao Hengjun +3 more
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