Results 151 to 160 of about 7,615 (291)

MODEL ARGUMENT DRIVEN INQUIRY (ADI) DENGAN MEMANFAATKAN GAMIFIKASI UNTUK MENINGKATKAN PENALARAN ILMIAH SISWA

Penelitian ini bertujuan untuk menerapkan penerapan model Argument Driven Inquiry dengan gamifikasi berbasis website wordwall dalam meningkatkan penalaran ilmiah siswa pada materi fluida statis.
Mulvia, Rahmadhani, Saadah, Fitrotus, Muhajir, Siti Nurdianti   +2 more
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IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Argument Driven Inquiry Learning Integrated with Expressive Writing: to Enhance Students' Critical Thinking and Argumentation Skills

Jurnal Ilmiah Profesi Pendidikan
Learning in the twenty-first century demands that individuals, including future educators, be capable of meeting the challenges of globalization by developing their potential and various essential skills. Among these, critical thinking and argumentation are particularly important.
Ria Saparianingsih, Nurani Hadnistia Darmawan, Silva Fadilah Suparman   +2 more
openaire   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Exploration of Students' Scientific Argumentation Ability through an Argument-Driven Inquiry Approach in Newton's Law Learning

Berkala Ilmiah Pendidikan Fisika
Scientific argumentation is an essential skill in science education, particularly in understanding Newton’s Laws, as it enables students to construct claims supported by evidence and logical reasoning based on real-world phenomena. However, many students struggle to produce complete and structured arguments.
Hesy Octaviandari, Lia Yuliati, Eny Latifah   +2 more
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Argument-Driven Inquiry Assisted by Lumi Education: Improving Students' Scientific Argumentation Skills on Static Electricity

Jurnal Penelitian dan Pengkajian Ilmu Pendidikan: e-Saintika
The aim of this study is to evaluate the effectiveness of the Argument-Driven Inquiry (ADI) learning strategy, supported by the Lumi Education platform, in enhancing the scientific argumentation skills of students related to static electricity. A quasi-experimental approach, employing a non-equivalent control group, was adopted in this study, including
Putri Avianita Salsabila, Ahmad Fauzi Hendratmoko, Fikky Dian Roqobih   +2 more
openaire   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

PENERAPAN MODEL ARGUMENT-DRIVEN INQUIRY YANG DIMODIFIKASI UNTUK MENGEMBANGKAN KETERAMPILAN PROSES SAINS DAN PENALARAN ILMIAH SISWA SMA PADA MATERI GERAK HARMONIK SEDERHANA [PDF]

, 2017
Penelitian ini bertujuan untuk mengetahui pola perkembangan keterampilan proses sains dan penalaran ilmiah melalui penerapan model argument-driven inquiry (ADI) yang dimodifikasi.
Hall, Jerry
core