Results 141 to 150 of about 7,615 (291)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

PENERAPAN MODEL PEMBELAJARAN ARGUMENT DRIVEN INQUIRY UNTUK MENINGKATKAN KUALITAS ARGUMENTASI PESERTA DIDIK PADA TOPIK PEMBELAJARAN KOMPONEN EKOSISTEM DAN INTERAKSINYA [PDF]

Kurangnya kualitas argumentasi peserta didik dalam kegiatan pembelajaran sehingga perlu ditingkatkan. Peningkatan kualitas argumentasi dapat dilakukan dengan strategi pembelajaran yang tepat yaitu dengan menggunakan model pembelajaran Argument Driven ...
Muhammad Ridzky Herdiana Pratama,
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

The Effect of Argument-Driven Inquiry (ADI) Model on Students' Critical Thinking Skills in Writing Argumentation Texts

KEMBARA Journal of Scientific Language Literature and Teaching
Critical thinking is an essential 21st-century skill that must be developed in Indonesian language learning, especially in writing argumentative texts. However, students' critical thinking skills remain low due to learning approaches that do not sufficiently encourage idea exploration and the structured development of arguments.
Lia Desi Amelia, Khaerudin Kurniawan, Isah Cahyani   +2 more
openaire   +1 more source

Enhancing Cognitive and Argumentation Skills through Integration of Argument-Driven Inquiry and the Scientific Method in Physics Education

Jurnal Pendidikan Fisika
Developing students’ cognitive abilities and scientific argumentation skills is critical in physics education, yet traditional teacher-centered approaches often fail to achieve these goals. This study investigates the impact of integrating the Argument-Driven Inquiry (ADI) model with the scientific method on students’ conceptual understanding and ...
Nurjannah, Nurjannah, Sani, Nurul Kami, Haeruddin, Haeruddin, Kade, Amiruddin, Khuzaimah, Andi Ulfah   +4 more
openaire   +2 more sources

Efektivitas Model Pembelajaran Argument-Driven Inquiry (ADI) Berbasis Sosioscientific Issue Terhadap Peningkatan Kemampuan Argumentasi di SMPN 1 Balong

, 2022
Kemampuan Argumentasi merupakan salah satu pengembangan keterampilan di abad 21 ini. Kemampuan Argumentasi peserta didik di salah satu kelas VII di SMP Negeri 1 Balong didapati belum memenunuhi KKM.
Iqbal, Muhammad
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Peningkatan penguasaan konsep siswa melalui pembelajaran argument driven inquiry pada pembelajaran IPA Terpadu di SMP kelas VII

Penguasaan konsep IPA yang masih rendah di sekolah-sekolah merupakan pekerjaan bersama dari praktisi pendidikan IPA. Pembelajaran IPA seharusnya dilakukan berdasarkan hakikat IPA itu sendiri yakni proses penyelidikan terhadap alam sekitar secara ...
Yuli Andriani
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The Impact of the Argument-Driven Inquiry (ADI) Instructional Model on Biodiversity Topics to Enhance Students' Argumentation Skills

Bioedunis Journal
This study aims to investigate the impact of Argument-Driven Inquiry (ADI)-based biology instruction on students' argumentation skills in the context of biodiversity. The research is classified as a quasi-experimental study using a pretest-posttest nonequivalent control group design.
Defrian Melta, Abdul Razak, Yohandri Yohandri   +2 more
openaire   +1 more source