Redox Biology, 2017 Artesunate, an anti-malarial drug, has been repurposed as an anticancer drug due to its induction of cell death via reactive oxygen species (ROS) production.
Jong-Lyel Roh, Eun Hye Kim
exaly +3 more sources
Spectrophotometric analysis of artesunate injections available in community pharmacies in Northern and Western Uganda [PDF]
Future Science OAAim The surge in different brands of artesunate injection in Uganda, has raised the need for this study, which aimed at quantifying the actual amount of artesunate in different brands of artesunate injections available in Northern and Western Uganda ...
Ebere Emilia Ayogu +4 more
doaj +2 more sources
EBioMedicine, 2015 Background: Artesunate is an antimalarial agent with broad anti-cancer activity in in vitro and animal experiments and case reports. Artesunate has not been studied in rigorous clinical trials for anticancer effects.
Sanjeev Krishna +2 more
exaly +3 more sources
Ameliorative Effects of Curcumin on Artesunate-Induced Subchronic Toxicity in Testis of Swiss Albino Male Mice [PDF]
Dose-Response, 2015 India is one of the endemic areas where control of malaria has become a formidable task. Artesunate is the current antimalarial drug used to treat malaria, especially chloroquine resistant.
Ketaki R. Desai +3 more
doaj +2 more sources
YM155, specific survivin inhibitor, can enhance artesunate-induced cytotoxicity in HCT116 colon cancer cells [PDF]
Korean Journal of Clinical Oncology, 2020 Purpose A water-soluble variant of the artemisinin called artesunate, approved as an antimalarial agent, can induce cell death on various cancer cell types. We studied the mechanism of cell death of artesunate on HCT116 colorectal cancer cells.
Eui Tae Kim, Dong-Guk Park
doaj +1 more source
Possible mechanisms of the hypoglycaemic effect of artesunate: Gender implication
Metabolism Open, 2021 Background: We investigated the mechanism of artesunate’s glucose-modulating effect especially with gender implication. Methods: Twenty-five (25) male and 25 female rats were separately and blindly allocated into five identical groups (n = 5/group ...
Abdullateef Isiaka Alagbonsi +4 more
doaj +1 more source
Preclinical Evaluation of Artesunate as an Antineoplastic Agent in Ovarian Cancer Treatment
Diagnostics, 2021 Background: Ovarian cancer is the deadliest gynecologic malignancy despite current first-line treatment with a platinum and taxane doublet. Artesunate has broad antineoplastic properties but has not been investigated in combination with carboplatin and ...
Anthony McDowell +7 more
doaj +1 more source
Efficacy and safety of artemether-lumefantrine (AL) and artesunate-amodiaquine (ASAQ) for the treatment of uncomplicated Plasmodium falciparum malaria in Liberia, 2022-2023. [PDF]
Malar JKoko VS +14 more
europepmc +3 more sources
Artesunate abolishes germinal center B cells and inhibits autoimmune arthritis. [PDF]
PLoS ONE, 2014 The antimalarial drug artemisinin and its derivatives exhibit potent immunosuppressive activity in several autoimmune disease models, however the mechanisms are not well-understood.
Lifei Hou +2 more
doaj +1 more source
Role of transferrin receptor and the ABC transporters ABCB6 and ABCB7 for resistance and differentiation of tumor cells towards artesunate. [PDF]
PLoS ONE, 2007 The anti-malarial artesunate also exerts profound anti-cancer activity. The susceptibility of tumor cells to artesunate can be enhanced by ferrous iron.
Gerhard Kelter +6 more
doaj +1 more source