Treatment Failure and Post-Artesunate Delayed Haemolysis in a Returned Traveller From Uganda With Partially Drug-Resistant Severe Plasmodium falciparum Malaria. [PDF]
Med J AustABSTRACT A man aged in his 40s, recently returned from Uganda, was hospitalised with Plasmodium falciparum malaria, with hyperparasitaemia of ~1.5 × 106 parasites/μL (26%). He received intravenous artesunate followed by artemether–lumefantrine. However, parasite clearance was delayed, and despite a negative blood film following treatment, the patient ...
Travis J +6 more
europepmc +2 more sources
Frontiers in Pharmacology, 2020 Objective: The purpose of this meta-analysis of longitudinal studies is to determine the safety and efficacy of artesunate combined with other forms of adjunctive therapies for severe malaria.Methods: Following the PRISMA guidelines, we searched multiple
Yuanyuan Zou +18 more
doaj +1 more source
Fractional curative killing of pyronaridine or artesunate combinations with tafenoquine, 4-aminoquinolines, or azithromycin in a murine malaria-luciferase model. [PDF]
Antimicrob Agents ChemotherLee G, Aneke JS, Sullivan DJ.
europepmc +2 more sources
Assessment of quantitative and semi-quantitative biological test methods of artesunate in vitro
Parasite, 2022 Artesunate is the current most potent antimalarial drug widely used for the treatment of malaria. Considering the emergence of artemisinin resistance, several situations may require a simple method for artesunate quantification.
Kouakou Yobouet Ines +6 more
doaj +1 more source
Preparations of Rectal Suppositories Containing Artesunate
Pharmaceutics, 2020 Rectal artesunate suppositories are a useful option for pre-referral treatment of severe malaria, specifically in children under 6 years of age in remote malaria-endemic areas.
Suzanne Persaud +4 more
doaj +1 more source
Artesunate acts through cytochrome c to inhibit growth of pediatric AML cells
Scientific Reports, 2023 Artesunate is a derivative of artemisinin, an active compound isolated from Artemisia annua which has been used in Traditional Chinese Medicine and to treat malaria worldwide. Artemisinin derivatives have exhibited anti-cancer activity against both solid
Kristen S. Hill +3 more
doaj +1 more source
Cannabis-Derived Compounds Against Plasmodium sp.: A Systematic Review of Preclinical Studies. [PDF]
Trop Med Int HealthABSTRACT Objective This study aims to evaluate preclinical studies on the effects and toxicity of cannabis‐derived compounds against Plasmodium sp. Methods A literature search was conducted in Web of Science, PubMed, Scopus and LILACS databases until December 2024. Studies that assessed the activity or toxicity of cannabis against Plasmodium sp.
de Mendonça Lima T +5 more
europepmc +2 more sources
Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine. [PDF]
, 2014 Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and P.
Adam, Ishag +62 more
core +4 more sources
Frontiers in Pharmacology, 2022 Chronic pain after bone fracture and orthopedic surgery is often refractory to most analgesics currently in use, thus emphasizing the urgent need for improved therapeutic medications.
Linlin Zhang +19 more
doaj +1 more source
Low efficacy of the combination artesunate plus amodiaquine for uncomplicated falciparum malaria among children under 5 years in Kailahun, Sierra Leone. [PDF]
, 2006 OBJECTIVE: In 2004, Sierra Leone adopted artesunate plus amodiaquine as first-line antimalarial treatment. We evaluated the efficacy of this combination in Kailahun, where a previous study had shown 70.2% efficacy of amodiaquine in monotherapy.
Balkan, S +8 more
core +2 more sources