Results 21 to 30 of about 30,074 (243)

In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up. [PDF]

, 2004
To determine the optimum duration of follow-up for the assessment of drug efficacy against Plasmodium falciparum malaria, 96 trial arms from randomized controlled trials (RCTs) with follow-up of 28 days or longer that were conducted between 1990 and 2003
Adjuik, M, Barnes, K, Day, N P J, Farrar, J, Guthmann, J P, Hien, T T, Looareesuwan, S, Mayxay, M, Myint, H Y, Nosten, F, Olliaro, P, Price, R, Pukrittayakamee, S, Smithuis, F, Stepniewska, K, Taylor, W R J, White, N J   +16 more
core   +3 more sources

Artemisinins [PDF]

, 2005
Artemisinins were discovered to be highly effective antimalarial drugs shortly after the isolation of the parent artemisinin in 1971 in China. These compounds combine potent, rapid antimalarial activity with a wide therapeutic index and an absence of ...
Haynes, RK, Krishna, S, Woodrow, CJ
core   +3 more sources

Review of pyronaridine anti-malarial properties and product characteristics. [PDF]

, 2012
Pyronaridine was synthesized in 1970 at the Institute of Chinese Parasitic Disease and has been used in China for over 30 years for the treatment of malaria.
Arbe-Barnes, Sarah J, Borghini-Fuhrer, Isabelle, Craft, J Carl, Croft, Simon L, Duparc, Stephan, Fleckenstein, Lawrence, Rim, Han-Jong, Shin, Chang-Sik   +7 more
core   +2 more sources

Artesunate shows potent anti-tumor activity in B-cell lymphoma

Journal of Hematology & Oncology, 2018
Background Although chemo-immunotherapy has led to an improved overall survival for most B-cell lymphoma types, relapsed and refractory disease remains a challenge. The malaria drug artesunate has previously been identified as a growth suppressor in some
Thea Kristin Våtsveen, Marit Renée Myhre, Chloé Beate Steen, Sébastien Wälchli, Ole Christian Lingjærde, Baoyan Bai, Pierre Dillard, Theodossis A. Theodossiou, Toril Holien, Anders Sundan, Else Marit Inderberg, Erlend B. Smeland, June Helen Myklebust, Morten P. Oksvold   +13 more
doaj   +1 more source

Effects of Artesunate on the Invasion of Lung Adenocarcinoma A549 Cells
and Expression of ICAM-1 and MMP-9

Chinese Journal of Lung Cancer, 2013
Background and objective Artesunate, an anti-malarial drug, elicits an inhibitory effect on pulmonary carcinoma. However, the mechanisms of artesunate activity on pulmonary carcinoma have not been completely elucidated.
Xianshan CHEN, Kunyuan HAN, Fengxia CHEN, Congming WU, Weiyi HUANG   +4 more
doaj   +1 more source

Safety and efficacy of methylene blue combined with artesunate or amodiaquine for uncomplicated falciparum malaria [PDF]

, 2008
Besides existing artemisinin-based combination therapies, alternative safe, effective and affordable drug combinations against falciparum malaria are needed. Methylene blue (MB) was the first synthetic antimalarial drug ever used, and recent studies have
Coulibaly, Boubacar, Klose, Christina, Kouyaté, Bocar, Mansmann, Ulrich, Meissner, Peter E., Mockenhaupt, Frank P., Müller, Olaf, Schirmer, R. Heiner, Sié, Ali, Walter-Sack, Ingeborg, Zoungrana, Augustin   +10 more
core   +1 more source

Efficacy and effectiveness of the combination of sulfadoxine/pyrimethamine and a 3-day course of artesunate for the treatment of uncomplicated falciparum malaria in a refugee settlement in Zambia. [PDF]

, 2005
In the Maheba Refugee Settlement, in the clinics supported by Medecins Sans Frontieres, all children aged up to 5 years with a confirmed diagnosis of uncomplicated falciparum malaria are treated with the combination of sulfadoxine/pyrimethamine (SP) and ...
Bloland PB, Contamin H, National Malaria Control Centre, Nosten F, Peterson DS, Trape JF, Vasconcelos KF, White NJ, World Health Organisation (WHO), World Health Organisation (WHO)   +9 more
core   +2 more sources

Socially-marketed rapid diagnostic tests and ACT in the private sector: ten years of experience in Cambodia. [PDF]

, 2011
Whilst some populations have recently experienced dramatic declines in malaria, the majority of those most at risk of Plasmodium falciparum malaria still lack access to effective treatment with artemisinin combination therapy (ACT) and others are already
A Marriot, A Talisuna, AM Dondorp, C Whitty, Cambodia National Institute of Public Health, Cambodia National Institute of Public Health, Cambodia National Institute of Public Health and Malaria Consortium, Cambodia National Institute of Public Health and National Institute of Statistics and ORC Macro, CG Kone, CIR Chandler, CS Molyneux, D Montagu, Duong Socheat, E Patouillard, E Patouillard, E Patouillard, E Rutebemberwa, Edith Patouillard, European Commission Cambodian Malaria Control Programme, G Yamey, GFATM, WHO, H Noedl, Henrietta Allen, IA Agyepong, Institute of Medicine, J Rozendaal, JD Njau, L Bury, LA Salako, Ministry of Health Department of Planning and Health Information, Ministry of Health National Centre for Parasitology, Ministry of Health National Centre for Parasitology Entomology and Malaria Control Programme, MJ Hamel, N Kikumbih, National Institute of Statistics Ministry of Planning of the Kingdom of Cambodia, O Sabot, OJ Sabot, PSI, PSI, PSI, Cambodia, RBM Task Force, RW Snow, S Incardona, S Yeung, SC McCombie, SD Foster, Shunmay Yeung, TK Ruebush, URC-MCC, WHO, World Health Organization, World Health Organization   +51 more
core   +4 more sources

Pre-referral intranasal artesunate powder for cerebral malaria: a proof-of-concept study

Malaria Journal, 2022
Background Malaria still kills young children in rural endemic areas because early treatment is not available. Thus, the World Health Organization recommends the administration of artesunate suppositories as pre-referral treatment before transportation ...
Yobouet Ines Kouakou, Aurelien Millet, Elodie Fromentin, Nathalie Hauchard, Gonçalo Farias, Maxime Fieux, Aurelie Coudert, Roukayatou Omorou, Ibrahim Bin Sa’id, Adeline Lavoignat, Guillaume Bonnot, Anne-Lise Bienvenu, Stephane Picot   +12 more
doaj   +1 more source

Recent Advances in the Therapeutic Efficacy of Artesunate

Pharmaceutics, 2022
Artesunate, a semisynthetic artemisinin derivative, is well-known and used as the first-line drug for treating malaria. Apart from treating malaria, artesunate has also been found to have biological activity against a variety of cancers and viruses.
Ngonidzashe Ruwizhi, Rejoice Bethusile Maseko, Blessing Atim Aderibigbe   +2 more
doaj   +1 more source