Results 51 to 60 of about 29,733 (246)
ChemistryOpen, EarlyView.Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel +5 more
wiley +1 more source
The Lancet Global Health, 2014 Background: Intravenous artesunate reduces mortality by 35% relative to intravenous quinine. In 2010, WHO changed guidelines favouring intravenous artesunate, yet wide-scale adoption lags.
Dr. Wilson Wang, MD +2 more
doaj +1 more source
The Antifungal Activity of Artesunate toward Candida albicans: Two Opposite Activities
Microbiology Indonesia, 2020 The artemisinin and its derivatives antifungal activity continue to be an interesting research object, with the potential shown to be developed as an antifungal compound.
MOHAMMAD RIZKI F ADHIL PRATAMA +2 more
doaj +1 more source
Cells, 2022 Although artesunate has been reported to be a promising candidate for colorectal cancer (CRC) treatment, the underlying mechanisms and molecular targets of artesunate are yet to be explored.
Zhiying Huang +11 more
doaj +1 more source
Cannabis‐Derived Compounds Against Plasmodium sp.: A Systematic Review of Preclinical Studies
Tropical Medicine &International Health, EarlyView.ABSTRACT Objective This study aims to evaluate preclinical studies on the effects and toxicity of cannabis‐derived compounds against Plasmodium sp. Methods A literature search was conducted in Web of Science, PubMed, Scopus and LILACS databases until December 2024. Studies that assessed the activity or toxicity of cannabis against Plasmodium sp.
Tácio de Mendonça Lima +5 more
wiley +1 more source
A reiterative method for calculating the early bactericidal activity of antituberculosis drugs.
, 2002 Studies of early bactericidal activity (EBA) are important in the rapid evaluation of new antituberculosis drugs. Historically, these have concentrated on the log fall in the viable count in sputum during the first 48 hours of therapy.
Charalambous, Bambos M +2 more
core +1 more source
Anti-malarial drug artesunate restores metabolic changes in experimental allergic asthma [PDF]
, 2016 The anti-malarial drug artesunate possesses anti-inflammatory and anti-oxidative actions in experimental asthma, comparable to corticosteroid. We hypothesized that artesunate may modulate disease-relevant metabolic alterations in allergic asthma.
Cheng, Chang +8 more
core +1 more source
Molecular Markers of Antimalarial Drug Resistance in Plasmodium falciparum From Kumasi, Ghana, 2023
Tropical Medicine &International Health, EarlyView.ABSTRACT Objectives Artemisinin partial resistance has emerged in East Africa and is feared to spread across the continent, potentially compromising artemisinin‐based combination treatment. Molecular markers can serve as early warning signals for the development of specific drug resistance.
Albert Dennis Kegya +10 more
wiley +1 more source
Journal of International Medical Research, 2021 Objective Inflammation is an important factor in the pathological process of cerebral ischemia. Artesunate exhibits a broad range of anti-inflammatory properties in many diseases.
Ying Liu +4 more
doaj +1 more source
GDF15 Is Elevated in Eating Disorders and Is Involved in the Gut‐Brain Axis via Ghrelin
European Eating Disorders Review, Volume 34, Issue 1, Page 151-162, January 2026.ABSTRACT Objective GDF15 induces anorexia and visceral discomfort, regulating appetite, food intake and potentially metabolic responses. However, its role in eating disorders remains unexplored. Method A total of 145 participants were recruited (60 patients with anorexia nervosa, 20 with bulimia nervosa, 13 with binge eating disorder, 52 participants ...
Livio Tarchi +14 more
wiley +1 more source