Results 51 to 60 of about 30,074 (243)

The Antifungal Activity of Artesunate toward Candida albicans: Two Opposite Activities

Microbiology Indonesia, 2020
The artemisinin and its derivatives antifungal activity continue to be an interesting research object, with the potential shown to be developed as an antifungal compound.
MOHAMMAD RIZKI F ADHIL PRATAMA, DARYONO HADI TJAHJONO, TUTUS GUSDINAR   +2 more
doaj   +1 more source

Genetic and genomic approaches for the discovery of parasite genes involved in antimalarial drug resistance [PDF]

, 2013
The biggest threat to the war on malaria is the continued evolution of drug resistance by the parasite. Resistance to almost all currently available antimalarials now exists in Plasmodium falciparum which causes the most suffering among all human malaria
Mwangi, J.M., Ranford-Cartwright, L.C.
core   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

First use of intravenous artesunate in Liberia and effect on patient mortality relative to artemeter and quinine: a cross-sectional study

The Lancet Global Health, 2014
Background: Intravenous artesunate reduces mortality by 35% relative to intravenous quinine. In 2010, WHO changed guidelines favouring intravenous artesunate, yet wide-scale adoption lags.
Dr. Wilson Wang, MD, Augustine Koryon, BS, Bernice Dahn, MD   +2 more
doaj   +1 more source

Artesunate Inhibits the Cell Growth in Colorectal Cancer by Promoting ROS-Dependent Cell Senescence and Autophagy

Cells, 2022
Although artesunate has been reported to be a promising candidate for colorectal cancer (CRC) treatment, the underlying mechanisms and molecular targets of artesunate are yet to be explored.
Zhiying Huang, Shu Gan, Xuerong Zhuang, Yao Chen, Linlin Lu, Ying Wang, Xiaoxiao Qi, Qian Feng, Qiuju Huang, Biaoyan Du, Rong Zhang, Zhongqiu Liu   +11 more
doaj   +1 more source

Anti-malarial drug artesunate restores metabolic changes in experimental allergic asthma [PDF]

, 2016
The anti-malarial drug artesunate possesses anti-inflammatory and anti-oxidative actions in experimental asthma, comparable to corticosteroid. We hypothesized that artesunate may modulate disease-relevant metabolic alterations in allergic asthma.
Cheng, Chang, Ho, Wanxing Eugene, Huang, Shao-Min, Ong, Choon Nam, Peh, Hong Yong, Tannenbaum, Steven R, Wong, W. S. Fred, Xu, Fengguo, Xu, Yong-Jiang   +8 more
core   +1 more source

Artemisinin‐Based Combination Therapies in East Africa: A Systematic Review of Quality, Clinical Efficacy, and Regulatory Progress Towards Sustainable Malaria Control

Tropical Medicine &International Health, EarlyView.
ABSTRACT Background Malaria is a major public health issue in East Africa, leading to widespread illness and fatalities, especially among vulnerable populations such as children under 5 years of age and pregnant women. Artemisinin‐based combination therapies (ACTs) are the primary treatment modality; however, their efficacy is undermined by the ...
Yesuneh Tefera Mekasha, Addisu Afrassa Tegegne, Tapfumanei Mashe, Million Girma, Gemmechu Hasen, Sileshi Belew   +5 more
wiley   +1 more source

Varying efficacy of artesunate+amodiaquine and artesunate+sulphadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in the Democratic Republic of Congo: a report of two in-vivo studies [PDF]

, 2009
BACKGROUND: Very few data on anti-malarial efficacy are available from the Democratic Republic of Congo (DRC). DRC changed its anti-malarial treatment policy to amodiaquine (AQ) and artesunate (AS) in 2005.
A Brockman, A Nahum, A Ndayiragije, AM Kabanywanyi, AO Talisuna, AP Alker, B Greenhouse, Chantal van Overmeir, CV Plowe, Célestin Nsibu Ndosimao, D Francis, Elizabeth Ashley, G Snounou, Ingrid van den Broek, Jean-Paul Guthmann, Jean-Paul Guthmann, JG Kublin, JG Kublin, JP Guthmann, Juliet Kyomuhendo, LC Ranford-Cartwright, M Ndounga, M Ndounga, Maryline Bonnet, Michel van Herp, MR Kamya, P Piola, Pedro Pablo Palma Urrutia, R Pearce, RN Price, S Cohuet, TB Swarthout, World Health Organization   +32 more
core   +2 more sources

Natural Products in Cancer Prevention and Therapy: Current Challenges and Future Directions

MedComm, Volume 7, Issue 2, February 2026.
Natural products play a pivotal role in cancer therapy. They induce cancer cell death by reprogramming four metabolic pathways while precisely targeting the tumor microenvironment and immune cells. These compounds not only leverage novel delivery systems for innovative applications but also demonstrate unique therapeutic efficacy across clinical stages:
Ruimiao Qian, Jun Ge, Ni Fan, Zheng Sun, Chengcheng Zhao, Yujiao Sun, Yingpeng Li, Yunfei Li, Hui Fu   +8 more
wiley   +1 more source

Glyoxalase‐1 Inhibition Leads to Ferroptosis Induction in Lung Cancer Cells: A Dual Mechanism of Action of Hydroxamic Acids Derived from Cysteine

ChemMedChem, Volume 21, Issue 1, January 2026.
A set of three cysteine‐derived hydroxamic acids were synthesized and evaluated for human gloxalase‐1 inhibition and ferroptosis induction activities. Among them, compound 2 exhibited a potent inhibitory effect against human glyoxalase‐1 and induced ferroptosis in non‐small cell lung cancer cell lines, increasing reactive oxygen species production and ...
Josué Martínez‐Miranda, Dolores Aguilar‐Cázares, Angélica Flores–Flores, Miguel Ángel Santos‐Contreras, José S. López‐González, Rodrigo Aguayo‐Ortiz, Rogélio Hernández‐Pando, Francisco Hernández‐Luis   +7 more
wiley   +1 more source