Results 61 to 70 of about 9,235,701 (287)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

A Simplified Car-following Model Based on the Artificial Potential Field

Procedia Engineering, 2016
AbstractCar-following models, which describe the interaction between successive vehicles in the same lane, have been studied for decades. A group of models are derived from the stimulus-response pattern concentrating on the effect of diverse stimulus type.
Li, Chenggang, Jiang, Xiaobei, Wang, Wuhong, Cheng, Qian, Shen, Yongjun   +4 more
openaire   +2 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Adaptive artificial potential field method for small autonomous vehicles [PDF]

Robotics and Autonomous Systems
Artificial Potential Field (APF) is one of the path planning and obstacle avoidance methods used for its simplicity and effectiveness. The goal’s attractive force and the obstacles’ repulsive forces are modeled and considered to act upon the vehicle or robot. However, in practice, the classical APF faces challenges like local minima.
Kemal Ihsan Kilic, Aurélien Desoeuvres, Casper Bak Pedersen, Alex Elkjær Vasegaard, Peter Nielsen   +4 more
openaire   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Research on Mobile Robot Path Planning Based on Artificial Potential Field and the Optimization of Artificial Potential Field

Highlights in Science, Engineering and Technology
Mobile robots play a significant role in enhancing the convenience of human life. Among the key research areas in mobile robotics, path planning is a central issue. Artificial Potential Field (APF), as a classic path planning algorithm, has received considerable attention.
openaire   +1 more source

An emergent wall following behaviour to escape local minima for swarms of agents [PDF]

, 2008
Natural examples of emergent behaviour, in groups due to interactions among the group's individuals, are numerous. Our aim, in this paper, is to use complex emergent behaviour among agents that interact via pair-wise attractive and repulsive potentials ...
Mabrouk, Mohamed H., McInnes, Colin R.
core   +3 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source