Results 81 to 90 of about 36,412 (300)

Evaluating the Endocrine‐Disrupting and Oxidative Stress Potential of a 50‐Component Human‐Relevant Complex Chemical Mixture Using In Vitro Tests

Journal of Applied Toxicology, EarlyView.
ABSTRACT Humans are chronically exposed to mixtures of environmental contaminants. Exposure to endocrine‐disrupting chemicals (EDCs) contributes to increased health impairment observed globally. This study aimed to evaluate the endocrine‐disruptive and oxidative stress potential of a human‐relevant, complex chemical mixture in vitro.
Josefin Engelhardt, Nathalie Struwe, Annika Jansson, Vesna Munic Kos, Maria Larsson, Jana M. Weiss   +5 more
wiley   +1 more source

Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma

Nature Communications, 2018
Resistance to BRAF inhibitors limits their clinical benefit in melanoma patients. Here, the authors show that the Aryl hydrocarbon Receptor (AhR) is a key mediator of resistant genes and use resveratrol, an AhR antagonist, to revert resistance in ...
Sébastien Corre, Nina Tardif, Nicolas Mouchet, Héloïse M. Leclair, Lise Boussemart, Arthur Gautron, Laura Bachelot, Anthony Perrot, Anatoly Soshilov, Aljosja Rogiers, Florian Rambow, Erwan Dumontet, Karin Tarte, Alban Bessede, Gilles J. Guillemin, Jean-Christophe Marine, Michael S. Denison, David Gilot, Marie-Dominique Galibert   +18 more
doaj   +1 more source

Occupational Exposure to Factory‐Derived Particulate Matter 2.5 Induces Cutaneous Toxicity in Workers and HaCaT Keratinocytes Through Oxidative Stress and Inflammation

Journal of Applied Toxicology, EarlyView.
ABSTRACT This study aimed to evaluate the toxicological effects of occupational exposure to factory‐derived particulate matter (PM2.5) on human skin, emphasizing its role as a potential target organ of environmental toxicants. An epidemiological survey comparing factory and nonfactory workers was conducted by assessing their skin elasticity and color ...
Miku Tanaka, Masayuki Takaishi, Iroha Okuda, Toshiki Fujimoto, Mayumi Tsuji, Yuri Okano, Yasuhiro Ishihara, Maori Kono   +7 more
wiley   +1 more source

Systemic Absorption and Pharmacokinetics of Five Novel Topical Dermatologic Agents: A Review

JEADV Clinical Practice, EarlyView.
ABSTRACT In recent years, innovative topical medications with novel mechanisms of action have emerged to treat common dermatologic conditions such as acne, atopic dermatitis, vitiligo, and actinic keratoses. These molecularly targeted therapies offer improved safety and tolerability compared to traditional options like corticosteroids.
Mary Dyson, Kara Hurley, Hannah Chaudhury, Lara Shehadeh, Cameron West   +4 more
wiley   +1 more source

Single cell analysis of kynurenine and System L amino acid transport in T cells

Nature Communications, 2018
Kynurenine is an immunomodulatory aryl hydrocarbon receptor (AHR) ligand. Here the authors show, using a new flow cytometry based method, that kynurenine needs to be transported across the plasma membrane of activated T cells by the transporter protein ...
Linda V. Sinclair, Damien Neyens, George Ramsay, Peter M. Taylor, Doreen A. Cantrell   +4 more
doaj   +1 more source

Building QSAR for HTS in vitro assays - a study for the prediction of Aryl hydrocarbon receptor activators [PDF]

, 2013
Ahmed Mohamed Abdelaziz, Alexander Safanyaev, Vladimir A. Palyulin, Igor V. Tetko   +3 more
openalex   +1 more source

Albumin‐Bilirubin Score as a Novel Prognostic Prediction Tool for Surgically Treated Head and Neck Squamous Cell Carcinoma

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT We investigated the prognostic significance of the preoperative albumin‐bilirubin (ALBI) score in surgically treated head and neck squamous cell carcinoma (HNSCC). This retrospective study included 663 patients who underwent radical surgery between 2007 and 2017.
Ming‐Hsien Tsai, Chao‐Hui Yang, Yu‐Tsai Lin, Hui‐Ching Chuang, Tai‐Lin Huang, Hui Lu, Wen‐Ling Tsai, Chih‐Yen Chien, Fu‐Min Fang   +8 more
wiley   +1 more source

Nonulcerated Necrobiosis Lipoidica Successfully Treated with Tapinarof: A Case Report

Clinical, Cosmetic and Investigational Dermatology, 2023
Samantha J Palomares, Aaron S Farberg Bare Dermatology, Dallas, TX, USACorrespondence: Aaron S Farberg, Tel +1 847 721 2725, Email aaron.farberg@gmail.comAbstract: Necrobiosis lipoidica (NL) is a chronic granulomatous disorder of the skin which usually ...
Palomares SJ, Farberg AS
doaj  

PDCD5 Contributes to Airway Epithelial Cell Damage via Mitochondrial Pathway and Participates in COPD Pathogenesis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Airway epithelial injury plays a critical role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Mitochondrial dysfunction is implicated in this injury, while the underlying mechanism remains incompletely understood. RNA sequencing was conducted to identify key genes involved in mitochondrial dysfunction in airway epithelial
Hu Shan, Rui Zhang, Yu‐er Li, Rui Li, Shao‐bo Ge, Jin Liu, Shi‐yuan Yao, Xia Yang, Tao Zhang, Ming Zhang   +9 more
wiley   +1 more source

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, EarlyView.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source